Archives of Plastic Surgery

Korean Society of Plastic and Reconstructive Surgeons (대한성형외과학회)
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The Effects of Topical Agent (Kelo-Cote or Contractubex) Massage on the Thickness of Post-Burn Scar Tissue Formed in Rats

  • Ko, Won Jin (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine) ;
  • Na, Young Cheon (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine) ;
  • Suh, Bum Sin (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine) ;
  • Kim, Hyeon A (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine) ;
  • Heo, Woo Hoe (Department of Plastic and Reconstructive Surgery, Wonkwang University Hospital, Wonkwang University School of Medicine) ;
  • Choi, Gum Ha (Department of Pathology, Wonkwang University Hospital, Wonkwang University School of Medicine) ;
  • Lee, Seo Ul (Wonkwang Institute of Clinical Medicine)
  • Received : 2013.07.05
  • Accepted : 2013.08.02
  • Published : 2013.11.15
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Abstract

Background We conducted an experimental study to compare the effect of massage using topical agents (Kelo-cote or Contractubex) on scar formation by massaging the healed burn wound on the dorsal area of Sprague-Dawley (SD) rats. Methods Four areas of second degree contact burn were made on the dorsal area of each of 15 SD rats, using a soldering iron 15 mm in diameter. After gross epithelialization in the defect, 15 SD rats were randomly divided into four groups: the Kelo-cote group, Contractubex group, Vaseline group, and control group. Rats in three of the groups (all but the Control group) were massaged twice per day for 5 minutes each day, while those in the Control group were left unattended. For histologic analysis, we performed a biopsy and evaluated the thickness of scar tissue. Results In the Kelo-cote and Contractubex groups, scar tissue thicknesses showed a significant decrease, compared with the Vaseline and control groups. However, no significant differences were observed between the Kelo-cote and Contractubex groups. In the Vaseline group, scar tissue thicknesses showed a significant decrease, compared with the control groups. Conclusions The findings of this study suggest that massage using a topical agent is helpful in the prevention of scar formation and that massage only with lubricant (no use of a topical agent) also has a considerable effect, although not as much as the use of a topical agent. Thus, we recommend massage with a topical agent on the post-burn scar as an effective method for decreasing the scar thickness.

Keywords

References

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