YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Formal Synthesis of Lespedezol $A_1$ via Versatile Palladium-Catalyzed Cross-Coupling of Diazochromanone with Arylboronic Acid

디아조크로마논과 보론산의 팔라듐 촉매하 결합반응을 이용한 Lespedezol $A_1$의 합성

  • Received : 2013.08.26
  • Accepted : 2013.09.23
  • Published : 2013.10.31
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Abstract

A formal synthesis of Lespedezol $A_1$ has been accomplished. The key feature of this synthesis involves an efficient and powerful palladium-catalyzed cross coupling reaction of diazocarbonyl compound with bis(benzyloxy)phenylboronic acid for the key 3-aryl-chromen-4-one intermediate, which was difficult to be prepared by Suzuki coupling reaction in the previous study. The versatile and efficient synthetic procedure would facilitate synthesis of pterocarpenes and their derivatives.

Keywords

References

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