YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Effects of Hovenia dulcis Fruit Hot Water Extracts on Anti-fatigue and Improvement of the Exercise Performance in SD Rats

랫드를 이용한 헛개나무과병 열수추출물 투여가 운동에 의한 피로회복과 운동수행능력에 미치는 기전 규명

  • Na, Chun-Soo (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.) ;
  • Kim, Hee Kyung (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.) ;
  • Kim, Jin Beom (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.) ;
  • Roh, Hyun Jeong (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.) ;
  • Um, Na-Na (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.) ;
  • Noh, Hae-Ji (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.) ;
  • Na, Dae-Seung (School of Life Sciences and Biotechnology, Korea University) ;
  • Dong, Mi-Sook (School of Life Sciences and Biotechnology, Korea University) ;
  • Hong, Cheol Yi (Lifetree Biotechnology Institute, Lifetree Bitotech Co. LTd.)
  • Received : 2013.08.22
  • Accepted : 2013.10.23
  • Published : 2013.10.31
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Abstract

The present study investigated the effects of Hovenia Dulcis (HD) fruit extract powder on the improvement of physical activity, especially exercise capacity. Forty mice were divided into 4 groups including normal controls, negative controls, 100 (HD-100) and 200 (HD-200) mg/kg HD fruit extract powder groups for 5-times exercises using treadmill. Normal control did not performed treadmill running but others did 5-times for 10 days. HD fruit extract powders were administrated orally one-times per day for 10 days before treadmill exercise and normal and negative controls were fed with excipient water. After 5-times exercise, blood biochemical analysis showed that aspartate aminotransferase (AST), lactate dehydrogenase (LDH) and creatine phosphokinase (CK) activities and blood lactate concentration were statistically increased in negative controls than in normal controls. They were decreased in HD fruit extract powder groups, compared with negative controls. These results were considered as the effects of HD fruit extract powders on reduced tissue damages during exercise. Other measured indices did not reveal remarkable differences. All together, these results suggest that HD fruit extract powders may enhance the exercise performance by recovering the exercise-fatigue via blood lactate concentration by reducing blood LDH activity and via reduction of blood CK and AST activity.

Keywords

References

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