Bulletin of the Korean Chemical Society

  • 제33권11호
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  • Pages.3635-3639
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  • 2012
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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Synthesis and Antiproliferative Activity of New Aminoisoquinolinylurea Derivatives against Melanoma Cell Line

  • Cho, Hye Jung (Chemical Kinomics Research Center, Korea Institute of Science and Technology) ;
  • El-Gamal, Mohammed I. (Center for Biomaterials, Korea Institute of Science and Technology) ;
  • Oh, Chang-Hyun (Center for Biomaterials, Korea Institute of Science and Technology) ;
  • Lee, So Ha (Chemical Kinomics Research Center, Korea Institute of Science and Technology) ;
  • Kim, Garam (College of Pharmacy, Chosun University) ;
  • Hong, Jun Hee (College of Pharmacy, Chosun University) ;
  • Choi, Hong Seok (College of Pharmacy, Chosun University) ;
  • Yoo, Kyung Ho (Chemical Kinomics Research Center, Korea Institute of Science and Technology)
  • 투고 : 2012.07.28
  • 심사 : 2012.08.08
  • 발행 : 2012.11.20
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초록

A series of new diarylureas possessing aminoisoquinoline scaffold was synthesized, and their in vitro antiproliferative activity against A375P human melanoma cell line was tested. Compounds 1d, 1l, 1n, 1p, 1q, and 1t showed superior potency against A375P to Sorafenib. The highest potency was shown by compound 1p possessing 3,5-bis(trifluoromethyl)phenyl terminal ring with $IC_{50}$ value of $0.41{\mu}M$.

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참고문헌

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