Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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New Safrole Oxide Derivatives: Synthesis and in vitro Antiproliferative Activities on A549 Human Lung Cancer Cells

  • Wang, Li-Ying (College of Pharmaceutical Sciences, Southwest University) ;
  • Wang, Xiu-Hua (College of Pharmaceutical Sciences, Southwest University) ;
  • Tan, Jia-Lian (College of Pharmaceutical Sciences, Southwest University) ;
  • Xia, Shuai (College of Pharmaceutical Sciences, Southwest University) ;
  • Sun, Heng-Zhi (College of Pharmaceutical Sciences, Southwest University) ;
  • Shi, Jin-Wen (College of Pharmaceutical Sciences, Southwest University) ;
  • Jiang, Ming-Dong (Department of Oncology, The Ninth People's Hospital of Chongqing) ;
  • Fang, Liang (Department of Oncology, The Ninth People's Hospital of Chongqing) ;
  • Zuo, Hua (College of Pharmaceutical Sciences, Southwest University) ;
  • Dupati, Gautam (Departments of Chemistry & Physics, Changwon National University) ;
  • Jang, Kiwan (Departments of Chemistry & Physics, Changwon National University) ;
  • Shin, Dong-Soo (Departments of Chemistry & Physics, Changwon National University)
  • Received : 2012.05.29
  • Accepted : 2012.08.01
  • Published : 2012.11.20
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Abstract

A number of novel small molecules, safrole oxide derivatives 4a-c, 6a-c, 9a-h, were synthesized by the reaction of safrole oxide with anilines 3 and 5, or its alkyl allyl ether derivative 7 with alkyl bromide 8 in moderate yields. The antiproliferative effects of all the target molecules on A549 cell growth were investigated and it was found that the 14 novel compounds could suppress A549 lung cancer cell growth. Among them, compound 6b was the most effective compound in inhibiting the proliferation of A549 cells.

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References

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