Journal of Applied Biological Chemistry

  • 제55권3호
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  • Pages.191-194
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  • 2012
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  • 1976-0442(pISSN)
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  • 2234-7941(eISSN)
한국응용생명화학회 (The Korean Society for Applied Biological Chemistry)
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새로운 피라졸린카르보티오아미드 화합물의 합성과 항암효과

Synthesis of Novel Pyrazolinecarbothioamide and Evaluation of Its Anti-Cancer Activity

  • Koh, Dongsoo (Dept. of Applied Chemistry, Dongduk Women's University)
  • 투고 : 2012.06.19
  • 심사 : 2012.07.20
  • 발행 : 2012.09.30
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초록

Novel pyrazolinecarbothioamide (5) was synthesized from chalcone (3) which was prepared from 2'-hydroxy-1'-acetonaphthone (1) and 2-methoxy benzaldehyde (2). Treatment of pyrazolinecarbothioamide (5) on HCT116 cancer cell showed upregulation of p21 and downregulation of cyclin D1 protein. Flowcytometer analysis revealed that pyrazolinecarbothioamide (5) controls the expression of cell cycle regulatory proteins, which blocks cell cycle progression of HCT116 cancer cell at the G1 phase.

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참고문헌

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