한국응용과학기술학회지 (Journal of the Korean Applied Science and Technology)

  • 제29권3호
  • /
  • Pages.435-442
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  • 2012
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  • 1225-9098(pISSN)
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  • 2288-1069(eISSN)
한국응용과학기술학회 (The Korean Society of Applied Science and Technology)
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Cytochrome P-450 2A6 Inhibitor Based on the Indole Moiety

  • Lee, Soo (Department of Chemical Engineering, Changwon National University) ;
  • Lee, Hyang-Yeol (Department of Biotechnology, Korea National University of Transportation)
  • 투고 : 2012.08.21
  • 심사 : 2012.09.25
  • 발행 : 2012.09.30
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초록

The cytochrome P-450 enzymes (CYP 2A6) regulate many endogenous signaling molecules and drugs. Aryl alkynes such as 2-ethynylnaphthalene are important P450 inhibitors which have been extensively studied as medicines or as an effective chemical probes for profiling mouse liver microsomal P-450. Here we have synthesized indole-based novel P450 inhibitor, 5-ethynyl indole 3, and showed that it has successfully inhibited CYP 2A6 by chemical inhibition reaction. By using HPLC equipped with a photo diode array(PDA) detector, all of the peaks derived from the enzymatic reaction have been characterized.

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참고문헌

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