YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

The Comparison between Sabaek-san Water and 30% EtOH Extracts for Anti-inflammatory Effects

사백산 물 추출물과 30% EtOH 추출물의 항염증 효과 비교연구

  • Lee, Dong-Sung (Hanbang Body-Fluid Research Center, Wonkwang University) ;
  • Choi, Hyun-Gyu (Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University) ;
  • Kim, Kyoung-Su (Standardized Material Bank for New Botanical Drugs, College of Pharmacy, Wonkwang University) ;
  • Kim, Dong-Cheol (College of Pharmacy, Wonkwang University) ;
  • Min, Hong-Ki (College of Pharmacy, Wonkwang University) ;
  • Li, Bin (Hanbang Body-Fluid Research Center, Wonkwang University) ;
  • Kim, Jong-Su (College of Pharmacy, Wonkwang University) ;
  • Park, Jun-Hyeong (College of Pharmacy, Wonkwang University) ;
  • Oh, Hyun-Cheol (College of Pharmacy, Wonkwang University) ;
  • Kim, Youn-Chul (Hanbang Body-Fluid Research Center, Wonkwang University)
  • 이동성 (원광대학교 한방체액조절연구센터) ;
  • 최현규 (원광대학교 약학대학 천연물신약표준화소재은행) ;
  • 김경수 (원광대학교 약학대학 천연물신약표준화소재은행) ;
  • 김동철 (원광대학교 약학대학) ;
  • 민홍기 (원광대학교 약학대학) ;
  • 리빈 (원광대학교 한방체액조절연구센터) ;
  • 김종수 (원광대학교 약학대학) ;
  • 박준형 (원광대학교 약학대학) ;
  • 오현철 (원광대학교 약학대학) ;
  • 김윤철 (원광대학교 한방체액조절연구센터)
  • Received : 2012.05.25
  • Accepted : 2012.08.12
  • Published : 2012.08.31
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Abstract

Sabaek-san has been used for the treatment of inflammatory diseases derived from the cold with high fever, cough, and lung dysfunction in Korea and China. There is no study for the comparison between different solvent extracts of Sabaek-san. We made two samples, one is Sabaek-san water extract (SBSW) and the other is Sabaek-san 30% EtOH extract (SBSE). Both extracts inhibited inducible nitric oxide synthase(iNOS) protein, reduced iNOS-derived nitric oxide (NO) production in lipopolysaccharide (LPS)-stimulated RAW264.7 cells. Also, they reduced tumor necrosis factor-${\alpha}$ (TNF-${\alpha}$) and interleukin-$1{\beta}$ (IL-$1{\beta}$) production. These anti-inflammatory effects caused by induction of heme oxygenase (HO)-1. HO-1 enzyme plays an important role of cellular anti-oxidant and anti-inflammatory systems. The induction of HO-1 is primarily regulated at the transcriptional level, and its induction by various inducers is related to the nuclear transcription factor-E2-related factor 2 (Nrf2). However, it is worth taking note that SBSE has more powerful anti-inflammatory effects than SBSW. In this study we suggest that different solvent extraction makes different therapeutic actions.

Keywords

References

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