Clinical and Experimental Pediatrics

The Korean Pediatric Society (대한소아청소년과학회)
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Urinary 6-sulfatoxymelatonin level in girls and its relationship with obesity

  • Lee, Ji-Eun (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Yoon, Ju-Young (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Lee, Jin-A (Department of Pediatrics, SMG-SNU Boramae Medical Center) ;
  • Lee, Seong-Yong (Department of Pediatrics, SMG-SNU Boramae Medical Center) ;
  • Shin, Choong-Ho (Department of Pediatrics, Seoul National University College of Medicine) ;
  • Yang, Sei-Won (Department of Pediatrics, Seoul National University College of Medicine)
  • Received : 2011.09.15
  • Accepted : 2012.06.14
  • Published : 2012.09.15
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Abstract

Purpose: Short sleep duration is associated with obesity. Urinary 6-sulfatoxymelatonin (6-OHMS), the principal metabolite of melatonin, is closely related with sleep. We evaluated the difference in urinary 6-OHMS levels between obese girls and normal weight girls, and the relationship of urinary 6-OHMS with other hormones regulating body weight and metabolism. Methods: A total of 79 girls (6.3 to 12.4 years) were included in this study, of whom 34 were obese; 15, overweight; and 30, normal-weight. We examined their pubertal status and bone age. Fasting serum levels of total ghrelin, leptin, insulin, and first morning urinary 6-OHMS were measured. Homeostatic model assessment-insulin resistance (HOMA-IR) was calculated from the fasting insulin and glucose levels. Results: There was no significant difference in the creatinine adjusted 6-OHMS levels between the obese girls and the control group. Urinary 6-OHMS did not show any correlations with body mass index (BMI), BMI percentile, total ghrelin, leptin, and HOMA-IR. Negative correlations were found between urinary 6-OHMS levels and chronological and bone ages. Conclusion: Our results suggest that melatonin production is not reduced consistently in obese girls.

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References

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