Investigative Magnetic Resonance Imaging

Korean Society of Magnetic Resonance in Medicine (대한자기공명의과학회)
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Structural and Functional Changes of Hippocampus in Long Life Experienced Taxi Driver

오랜 운전경험을 가진 택시운전기사들의 해마의 구조와 기능적 변화에 대한 MRI연구

  • You, Myung-Won (Department of Radiology, Graduate School of Medicine, Kyung Hee University) ;
  • Lee, Dong-Kyun (Computational NeuroImage Analysis Lab, Department of Biomedical Engineering, Hanyang University) ;
  • Lee, Jong-Min (Computational NeuroImage Analysis Lab, Department of Biomedical Engineering, Hanyang University) ;
  • Kim, Sun-Mi (Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University) ;
  • Ryu, Chang-Woo (Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University) ;
  • Kim, Eui-Jong (Department of Radiology, Kyung Hee University Hospital, School of Medicine, Kyung Hee University) ;
  • Jahng, Geon-Ho (Department of Radiology, Kyung Hee University Hospital at Gangdong, School of Medicine, Kyung Hee University)
  • 유명원 (경희대학교 의과대학 대학원 영상의학과) ;
  • 이동균 (한양대학교 생명공학부) ;
  • 이종민 (한양대학교 생명공학부) ;
  • 김선미 (경희대학교 의과대학 강동경희대병원 영상의학과) ;
  • 류창우 (경희대학교 의과대학 강동경희대병원 영상의학과) ;
  • 김의종 (경희대학교 의과대학 경희의료원 영상의학과) ;
  • 장건호 (경희대학교 의과대학 강동경희대병원 영상의학과)
  • Received : 2012.05.07
  • Accepted : 2012.08.24
  • Published : 2012.08.31
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Abstract

Purpose : The objective of this study was to investigate the differences of hippocampal volume and shape as well as the functional change between long life experienced taxi drivers and controls of Korean population. Materials and Methods: Three-dimensional T1-weighted images and blood oxygen level dependent functional MRI(fMRI) were obtained from 8 subjects, consisting of 4 experienced (20-30 years) taxi drivers and 4 age-matched controls. The hippocampal volume and shape were analyzed with three-dimensional T1-weighted images. In addition, neuronal activities of brain were analyzed using a blood oxygen level dependent fMRI between the two groups. Results: The hippocampal volume showed no statistically significant difference between the two groups (p > 0.05). The left hippocampi of the taxi drivers were slightly elongated with larger head and tail portions than those of the controls (p < 0.05, uncorrected). For the functional MRI, fusiform gyrus was specifically activated in taxi drivers, compared with the control group. Conclusion: The structural and functional changes of taxi driver's hippocampus indicate the functional differentiation as a result of occupational dependence on spatial navigation. In other words, the continuous usage of spatial navigation performance may diminish degeneration of hippocampus and the related brain regions.

목적: 본 연구에서는 숙달된 택시운전기사들을 대상으로 내비게이션 시스템을 이용하여 운전하는 한국인 대조군에 비교하여 해마의 부피와 모양 그리고 기능적 변화를 알아보고자 하였다. 대상과 방법: 총 8명의 대상군(4명의 숙달된 택시운전기사들과 4명의 같은 나이대 일반인 대조군)에 대해 삼차원 T1강조영상과 혈류산소 수준에 따른 기능성 자기공명영상을 촬영하였다. 해마의 용적과 모양, 기능성 자기공명영상 자료를 분석하여 두 군간에 신경 활성도 차이를 비교하였다. 결과: 해마의 용적은 두 군간에 통계적으로 유의한 차이를 보이지 않았다(p > 0.05). 해마의 모양을 보면, 택시운전기사군의 왼쪽 해마가 대조군에 비해 전체 길이가 약간 길고 머리와 꼬리부분이 약간 더 컸다(p < 0.05, uncorrected). 기능성 자기공명영상에서는 택시운전기사군에서 대조군에 비해 방추상회가 특히 활성화되어 있었다. 결론: 택시운전기사군의 해마가 보이는 이러한 구조적, 기능적 변화는 그들의 직업과 관련하여 공간적 탐색능력을 지속적으로 사용하면서 해마와 관련 뇌영역이 기능적으로 분화했음을 나타내는 소견으로 추측할 수 있겠다.

Keywords

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