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Antimicrobial resistance and frequency of BlaTEM in Escherichia coli isolated from non-diarrheic and diarrheic piglets

정상돈과 설사돈에서 분리한 대장균의 항균제 내성 및 BlaTEM 분포 조사

  • Byun, Jae Won (Animal Disease Diagnostic Division, Animal, Plant & Fisheries Quarantine and Inspection Agency) ;
  • Kim, Ha Young (Animal Disease Diagnostic Division, Animal, Plant & Fisheries Quarantine and Inspection Agency) ;
  • Jung, Byeong Yeal (Animal Disease Diagnostic Division, Animal, Plant & Fisheries Quarantine and Inspection Agency) ;
  • Bae, You Chan (Animal Disease Diagnostic Division, Animal, Plant & Fisheries Quarantine and Inspection Agency) ;
  • Lee, Wan Kyu (College of Veterinary Medicine, Chungbuk National University)
  • 변재원 (농림수산검역검사본부 질병진단과) ;
  • 김하영 (농림수산검역검사본부 질병진단과) ;
  • 정병열 (농림수산검역검사본부 질병진단과) ;
  • 배유찬 (농림수산검역검사본부 질병진단과) ;
  • 이완규 (충북대학교 수의과대학)
  • Received : 2012.04.24
  • Accepted : 2012.06.25
  • Published : 2012.06.30

Abstract

Antimicrobial resistance is one of the most concerns in pig industry. Escherichia (E.) coli have been used for the indicator to monitor the antimicrobial resistance. In this study, 321 E. coli from diarrheic and non-diarrheic piglets were tested for antimicrobial resistance and frequency of $Bla_{TEM}$. In non-diarrheic piglets, they were resistant to oxytetracycline (93%), streptomycin (92%) and sulfadiazine (90%) but susceptible to ceftiofur (99%), colistin (97%), and enrofloxacin (82%). The isolates from diarrheic piglets were resistant to enrofloxacin (72.9%), ceftiofur (17.6%), and colistin (11.3%), whereas the resistance was 1%, 18% and 3% in case of non-diarrheic piglets, respectively. The resistance for amoxicillin/clavulanic acid (54.1%) and ceftiofur (22%) was high in isolates from post-weaning piglets. The resistance for colistin was 15.2% in nursery piglets. Seventy-three percent of isolates from diarrheic piglets showed high multidrug resistance profile (more than 13 antimicrobials) compared to those from non-diarrheic pigs in which 71% of isolates showed moderate multidrug resistance profile (7 to 12 antimicrobials). The frequency of $Bla_{TEM}$ in E. coli from non-diarrheic and diarrheic piglets was 57% and 69%, respectively. The results might provide the basic knowledge to establish the strategies for treatment and reduce antibiotic resistance of E. coli in piglets.