Korean Journal of Fisheries and Aquatic Sciences (한국수산과학회지)

The Korean Society of Fisheries and Aquatic Science (한국수산과학회)
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Anti-angiogenesis Activity and Characterization of Extract of Ark Shell Scapharca subcrenata

새꼬막(Scapharca subcrenata) 추출물의 혈관신생 억제활성과 특성

  • Lim, Chi-Won (Food & Safety Division, National Fisheries Research & Development Institute) ;
  • Park, Hee-Yeon (Food & Safety Division, National Fisheries Research & Development Institute) ;
  • Shim, Kil-Bo (Food & Safety Division, National Fisheries Research & Development Institute) ;
  • Yoon, Na-Young (Food & Safety Division, National Fisheries Research & Development Institute) ;
  • Kim, Yeon-Kye (Southwest Sea Fisheries Research Institute, National Fisheries Research & Development Institute)
  • 임치원 (국립수산과학원 식품안전과) ;
  • 박희연 (국립수산과학원 식품안전과) ;
  • 심길보 (국립수산과학원 식품안전과) ;
  • 윤나영 (국립수산과학원 식품안전과) ;
  • 김연계 (국립수산과학원 남서해수산연구소)
  • Received : 2012.03.08
  • Accepted : 2012.08.03
  • Published : 2012.08.31
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Abstract

Anti-angiogenesis therapy is one of the most promising strategies for the treatment of cancer. We investigated the anti-angiogenesis activity of an extract from the ark shell Scapharca subcrenata and attempted to purify the active compounds. The crude extract of the ark shell inhibited the proliferation of human vein endothelial cells (HUVEC-1) and tube formation by human dermal microvascular endothelial cells (HMEC-1). The methanol extract of the viscera of the ark shell showed activity. The ark shell extract acts as an angiogenesis inhibitor and could be developed further as a health substance, functional food, and anticancer agent.

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References

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