Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Effect of Ginkgo biloba extract on the survival rate in lipopolysaccharide-induced sepsis model mice

Lipopolysaccharide로 유도한 패혈증 모델에서 Ginkgo biloba extract 투여가 생존율에 미치는 영향

  • Rhee, Ki-Jong (Department of Biomedical Laboratory Science, College of Health Sciences, Yonsei University) ;
  • Kim, Hyeon-Cheol (College of Veterinary Medicine, Kangwon National University) ;
  • Jung, Bae-Dong (College of Veterinary Medicine, Kangwon National University)
  • 이기종 (연세대학교 보건과학대학 임상병리학과) ;
  • 김현철 (강원대학교 수의과대학) ;
  • 정배동 (강원대학교 수의과대학)
  • Received : 2012.07.02
  • Accepted : 2012.08.13
  • Published : 2012.09.30
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Abstract

Accumulated evidence indicate that Ginkgo biloba extract (EGb 761) acts as an antioxidant and scavenger of free radicals as well as influencing apoptotis. Earlier studies have employed the inflammatory agent lipopolysaccharide (LPS) to induce severe sepsis. In the present study, we examined whether the intraperitoneal injection of EGb 761 increases the survival rate of mice in the LPS-induced severe sepsis model. The survival rate was significantly increased by 30% in mice administered with 100 mg/kg of EGb 761 but not in mice administered with 50 mg/kg EGb 761. In addition, pre-treatment with EGb 761 increased the survival rate (30%) but post-treatment with EGb 761 did not. These results suggest that EGb 761 may have clinical potential in preventing sepsis induced mortality.

Keywords

References

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