Bulletin of the Korean Chemical Society

  • 제33권9호
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  • Pages.2903-2906
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  • 2012
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  • 0253-2964(pISSN)
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  • 1229-5949(eISSN)
대한화학회 (Korean Chemical Society)
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A Straightforward Synthesis of K-7174, a GATA-Specific Inhibitor

  • Majik, Mahesh S. (Department of Bioinspired Science and Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Yu, Jin-Ha (Department of Bioinspired Science and Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University) ;
  • Jeong, Lak-Shin (Department of Bioinspired Science and Laboratory of Medicinal Chemistry, College of Pharmacy, Ewha Womans University)
  • 투고 : 2012.04.30
  • 심사 : 2012.05.29
  • 발행 : 2012.09.20
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초록

K-7174, a GATA-specific inhibitor, is a putative anti-inflammatory agent that attenuates effects of inflammatory cytokines in certain cell types. An expeditious four-step synthesis of K-7174 is described in this paper. The route employs Wittig olefination and bis-alkylation of homopiperazine as the key reactions. The iodine-catalyzed isomerization of the Z-isomer results in complete conversion to the E-isomer is the highlight of our synthetic endeavors.

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피인용 문헌

  1. Do reciprocal interactions between cell stress proteins and cytokines create a new intra-/extra-cellular signalling nexus? vol.18, pp.6, 2013, https://doi.org/10.1007/s12192-013-0444-9