Toxicological Research

  • 제28권3호
  • /
  • Pages.173-178
  • /
  • 2012
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

Human Health Risk Assessment of Trichloroethylene from Industrial Complex A

  • Sin, Sae-Mi (Department of Environmental Health, College of Health Sciences, Korea University) ;
  • Byeon, Sang-Hoon (Department of Environmental Health, College of Health Sciences, Korea University)
  • 투고 : 2012.08.09
  • 심사 : 2012.09.26
  • 발행 : 2012.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

This study investigated the human health risks of trichloroethylene from Industrial Complex A. The excessive carcinogenic risks for central tendency exposure were $1.40{\times}10^{-5}$ for male and female residents in the vicinity of Industrial Complex A. The excessive cancers risk for reasonable maximum exposure were $2.88{\times}10^{-5}$ and $1.97{\times}10^{-5}$ for males and females, respectively. These values indicate that there are potential cancer risks for exposure to these concentrations. The hazard index for central tendency exposure to trichloroethylene was 1.71 for male and female residents. The hazard indexes for reasonable maximum exposure were 3.27 and 2.41 for males and females, respectively. These values were over one, which is equivalent to the threshold value. This result showed that adverse cancer and non-cancer health effects may occur and that some risk management of trichloroethylene from Industrial Complex A was needed.

키워드

참고문헌

  1. Brüning, T., Pesch, B., Wiesenhütter, B., Rabstein, S., Lammert, M., Baumuller, A. and Bolt, H.M. (2003). Renal cell cancer risk and occupational exposure to trichloroethylene: Results of a consecutive case-control study in Arnsberg, Germany. Am. J. Ind. Med., 43, 274-285. https://doi.org/10.1002/ajim.10185
  2. Charbotel, B., Fevotte, J., Hours, M., Martim, J.L. and Bergeret, A. (2006). Case-control study on renal cell cancer and occupational exposure to trichloroethylene. Part II: Epidemiological aspects. Ann. Occup. Hyg., 50, 777-787. https://doi.org/10.1093/annhyg/mel039
  3. Dobkin, A.B. and Byles, P.H. (1963). Trichlorethylene anesthesia. Clin. Anesth., 1, 43-65.
  4. Dorfmueller, M.A., Henne, S.P., York, R.G., Bornschein, R.L. and Manson, J.M. (1979). Evaluation of teratogenicity and behavioral toxicity with inhalation exposure of maternal rats to trichloroethylene. Toxicology, 14, 153-166. https://doi.org/10.1016/0300-483X(79)90061-1
  5. Dorhertya, R.E. (2000). A history of the production and use of carbon tetrachloride, tetrachloroethylene, trichloroethylene and 1,1,1-trichloroethane in the united states: Part 2--trichloroethylene and 1,1,1-trichloroethane. Environ. Forensics, 1, 83- 93. https://doi.org/10.1006/enfo.2000.0011
  6. Foster, K.R., Vecchia, P. and Repacholi, M.H. (2000). Risk management. Science and the precautionary principle. Science, 288, 979-981. https://doi.org/10.1126/science.288.5468.979
  7. Foy, B.R., Waldthausen, K., Sedillo, M.A. and Buelow, S.J. (1996). Hydrothermal processing of chlorinated hydrocarbons in a titanium reactor. Environ. Sci. Technol., 30, 2790- 2799. https://doi.org/10.1021/es960041o
  8. Fukuda, K., Takemoto, K. and Tsuruta, H. (1983). Inhalation carcinogenicity of trichloroethylene in mice and rats. Ind. Health, 21, 243-254. https://doi.org/10.2486/indhealth.21.243
  9. Gist, G.L. and Burg, J.R. (1995). Trichloroethylene — a review of the literature from a health effects perspective. Toxicol. Ind. Health, 11, 253-307. https://doi.org/10.1177/074823379501100301
  10. Henschler, D., Romen, W., Elsaesser, H.M., Reichert, D., Eder, E. and Radwan, Z. (1980). Carcinogenicity study of trichloroethylene by longterm inhalation in three animal species. Arch. Toxicol., 43, 237-248. https://doi.org/10.1007/BF00366179
  11. Herren-Freund, S.L., Pereira, M.A., Khoury, M.D. and Olson, G. (1987). The carcinogenicity of trichloroethylene and its metabolites, trichloroacetic acid and dichloroacetic acid, in mouse liver. Toxicol. Appl. Pharmacol., 90, 183-189. https://doi.org/10.1016/0041-008X(87)90325-5
  12. Johnson, P.D., Goldberg, S.J., Mays, M.Z. and Dawson, B.V. (2003). Threshold of trichloroethylene contamination in maternal drinking waters affecting fetal heart development in the rat. Environ. Health Perspect., 111, 282-292. https://doi.org/10.1289/ehp.111-a282
  13. Keil, D.E., Peden-Adams, M.M., Wallace, S., Ruiz, P. and Gilkeson, G.S. (2009). Assessment of trichloroethylene (TCE) exposure in murine strains genetically-prone and non-prone to develop autoimmune disease. J. Environ. Sci. Health A Tox. Hazard Subst. Environ. Eng., 44, 443-453. https://doi.org/10.1080/10934520902719738
  14. Kim, S., Cheong, H.K., Choi, K., Yang, J.Y., Kim, S.J., Jo, S.N. and Jang, J.Y. (2006). Development of Korean Exposure Factors Handbook for Exposure Assessment. Epidemiology, 17, S460.
  15. Landrigan, P.J., Kominsky, J.R., Stein, G.F., Ruhe, R.L. and Watanabe, A.S. (1987). Common-source community and industrial exposureto trichloroethylene. Arch. Environ. Health, 42, 327-332. https://doi.org/10.1080/00039896.1987.9934354
  16. Lilis, R., Stanescu, D., Muica, N. and Roventa, A. (1969). Chronic effects of trichloroethylene exposure. Med. Lav., 60, 595-601.
  17. Maltoni, C., Lefemine, G., Cotti, G. and Perino, G. (1988). Longterm carcinogenicity bioassays on trichloroethylene administered by inhalation to Sprague-Dawley rats and Swiss and B6C3F1 mice. Ann. N. Y. Acad. Sci., 534, 316-342. https://doi.org/10.1111/j.1749-6632.1988.tb30120.x
  18. Moore, L.E., Boffetta, P., Karami, S., Brennan, P., Stewart, P.S., Hung, R., Zaridze, D., Matveev, V., Janout, V., Kollarova, H., Bencko, V., Navratilova, M., Szeszenia-Dabrowska, N., Mates, D., Gromiec, J., Holcatova, I., Merino, M., Chanock, S., Chow, W.H. and Rothman, N. (2010). Occupational trichloroethylene exposure and renal carcinoma risk: Evidence of genetic susceptibility by reductive metabolism gene variants. Cancer Res., 70, 6527-6536. https://doi.org/10.1158/0008-5472.CAN-09-4167
  19. Morgan, J.W. and Cassady, R.E. (2002). Community cancer assessment in response to long-time exposure to perchlorate and trichloroethylene in drinking water. J. Occup. Environ. Med., 44, 616-621. https://doi.org/10.1097/00043764-200207000-00005
  20. Na, K., Kim, Y.P., Moon, K.C., Moon, I. and Fung, K. (2001). Concentrations of volatile organic compounds in an industrial area of Korea. Atmos. Environ., 35, 2747-2756. https://doi.org/10.1016/S1352-2310(00)00313-7
  21. Page, N.N. (1979). Assessment of trichloroethylene as an occupational carcinogene. IARC Sci. Publ., 25, 75-79.
  22. Raaschou-Nielsen, O., Hansen, J., McLaughlin, J.K., Kolstad, H., Christensen, J.M., Tarone, R.E. and Olsen, J.H. (2003). Cancer risk among workers at Danish companies using trichloroethylene: A cohort study. Am. J. Epidemiol., 158, 1182- 1192. https://doi.org/10.1093/aje/kwg282
  23. Radican, L., Blair, A., Stewart, P. and Wartenberg, D. (2008). Mortality of aircraft maintenance workers exposed to trichloroethylene and other hydrocarbons and chemicals: Extended followup. J. Occup. Environ. Med., 50, 1306-1319. https://doi.org/10.1097/JOM.0b013e3181845f7f
  24. Shin, H.S. and Ahn, H. (2004). The study on the measurement of volatile organic compounds in the air of A and B industrial area. Anal. Sci. Technol., 17, 130-144.
  25. Vartiainen, T., Pukkala, E., Rienoja, T., Strandman, T. and Kak sonen, K. (1993). Population exposure to tri- and tetrachloroethene and cancer risk: Two cases of drinking water pollution. Chemosphere, 27, 1171-1181. https://doi.org/10.1016/0045-6535(93)90165-2
  26. Williams, P.R. and Paustenbach, D.J. (2002). Risk characterization: Principles and practrice. J. Toxicol. Environ. Health B Crit. Rev., 5, 337-406. https://doi.org/10.1080/10937400290070161
  27. Zhao, Y., Krishnadasan, A., Kennedy, N., Morgenstern, H. and Ritz, B. (2005). Estimated effects of solvents and mineral oils on cancer incidence and mortality in a cohort of aerospace workers. Am. J. Ind. Med., 48, 249-258. https://doi.org/10.1002/ajim.20216