Toxicological Research

  • 제28권3호
  • /
  • Pages.159-164
  • /
  • 2012
  • /
  • 1976-8257(pISSN)
  • /
  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
권호 표지
DOI QR코드

DOI QR Code

External Application of Fermented Olive Flounder (Paralichthys olivaceus) Oil Alleviates Inflammatory Responses in 2,4-Dinitrochlorobenzene-induced Atopic Dermatitis Mouse Model

  • Han, Sang-Chul (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Kang, Gyeoung-Jin (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Ko, Yeong-Jong (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Kang, Hee-Kyoung (Department of Pharmacology, School of Medicine, Jeju National University) ;
  • Moon, Sang-Wook (Fermentec Inc.) ;
  • Ann, Yong-Seok (Choung Ryong Fisheries Co. Ltd.) ;
  • Yoo, Eun-Sook (Department of Pharmacology, School of Medicine, Jeju National University)
  • 투고 : 2012.08.05
  • 심사 : 2012.08.24
  • 발행 : 2012.09.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Allergic skin inflammation such as atopic dermatitis (AD) is characterized by edema and infiltration with various inflammatory cells such as mast cells, basophils, eosinophils and T cells. Thymic stromal lymphopoietin (TSLP) is produced mainly by epidermal keratinocytes, as well as dermal fibroblasts and mast cells in the skin lesions of AD. Omega-3 polyunsaturated fatty acids in fish oil can reduce inflammation in allergic patients. Fermentation has a tremendous capacity to transform chemical structures. The antiinflammatory effects of fish oil have been described in many diseases, but the beneficial effects by which fermented olive flounder oil (FOF) modulates the allergic response is poorly understood. In this study, we produced FOF and tested its ability to suppress the various allergic inflammatory responses. The ability of FOF to modulate the immune system was investigated using a mouse model of AD. The FOF-treated group showed significantly decreased immunoglobulin E (IgE) and histamine in serum. Also, the increased TSLP expression was significantly inhibited in the FOF group; the FOF-treated group was not appreciably different from the hydrocort cream treatment group. In addition, FOF treatment resulted in a smaller spleen size with reduced the thickness and length compared to the induction group. Splenocytes from mice treated with FOF produced significantly less IFN-${\gamma}$, IL-4, T-box transcription factor (T-bet) and GATA binding protein 3 (GATA3) expression compared with the induction group. These results suggest that FOF may be effective in treating the allergic symptoms of AD. 5.

키워드

참고문헌

  1. Al-Shami, A., Spolski, R., Kelly, J., Keane-Myers, A. and Leonard, W.J. (2005). A role for TSLP in the development of inflammation in an asthma model. J. Exp. Med., 202, 829-839. https://doi.org/10.1084/jem.20050199
  2. Bogiatzi, S.I., Fernandez, I., Bichet, J.C., Marloie-Provost, M.A., Volpe, E., Sastre, X. and Soumelis, V. (2007). Cutting edge: Proinflammatory and Th2 cytokines synergize to induce thymic stromal lymphopoietin production by human skin keratinocytes. J. Immunol., 178, 3373-3377. https://doi.org/10.4049/jimmunol.178.6.3373
  3. de Vries, I.J., Langeveld-Wildschut, E.G., van Reijsen, F.C., Bihari, I.C., Bruijnzeel-Koomen, C.A. and Thepen, T. (1997). Nonspecific T-cell homing during inflammation in atopic dermatitis: Expression of cutaneous lymphocyte-associated antigen and Integrin alphaE beta7 on skin-infiltrating T cells. J. Allergy Clin. Immunol., 100, 694-701. https://doi.org/10.1016/S0091-6749(97)70175-1
  4. Debes, G.F., Bonhagen, K., Wolff, T., Kretschmer, U., Krautwald, S., Kamradt, T. and Hamann, A. (2004). CC chemokine receptor 7 expression by effector/memory CD4+ T cells depends on antigen specificity and tissue localization during influenza a virus infection. J. Virol., 78, 7528-7535. https://doi.org/10.1128/JVI.78.14.7528-7535.2004
  5. Ebner, S., Nguyen, V.A., Forstner, M., Wang, Y.H., Wolfram, D., Liu, Y.J. and Romani, N. (2007). Thymic stromal lymphopoietin converts human epidermal langerhans cells into antigenpresenting cells that induce proallergic T cells. J. Allergy Clin. Immunol., 119, 982-990. https://doi.org/10.1016/j.jaci.2007.01.003
  6. Elson, C.O., Cong, Y., Brandwein, S., Weaver, C.T., McCabe, R.P., Mähler, M., Sundberg, J.P. and Leiter, E.H. (1998). Experimental models to study molecular mechanisms underlying intestinal inflammation. Ann. N. Y. Acad. Sci., 859, 85-95. https://doi.org/10.1111/j.1749-6632.1998.tb11113.x
  7. Ginsberg, G.L. and Toal, B.F. (2009). Quantitative approach for incorporating methylmercury risks and omega-3 fatty acid benefits in developing species-specific fish consumption advice. Environ Health Perspect., 117, 267-275. https://doi.org/10.1289/ehp.11368
  8. Glimcher, L.H. and Murphy, K.M. (2000). Lineage commitment in the immune system: The T helper lymphocyte grows up. Genes Dev., 14, 1693-1711.
  9. Isobe, N., Suzuki, M., Oda, M. and Tanabe, S. (2008). Enzymemodified cheese exerts inhibitory effects on allergen permeation in rats suffering from indomethacin-induced intestinal inflammation. Biosci. Biotechnol. Biochem., 72, 1740-1745. https://doi.org/10.1271/bbb.80042
  10. Kawakami, T., Ando, T., Kimura, M., Wilson, B.S. and Kawakami, Y. (2009). Mast cells in atopic dermatitis. Curr. Opin. Immunol., 21, 666-678. https://doi.org/10.1016/j.coi.2009.09.006
  11. Kitamura, Y. and Ito, A. (2005). Mast cell-committed progenitors. Proc. Natl. Acad. Sci. U.S.A., 102, 11129-11130. https://doi.org/10.1073/pnas.0505073102
  12. Krauss-Etschmann, S., Hartl, D., Rzehak, P., Heinrich, J., Shadid, R., Del Carmen Ramirez-Tortosa, M., Campoy, C., Pardillo, S., Schendel, D.J., Decsi, T., Demmelmair, H. and Koletzko, B.V. (2008). Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J. Allergy Clin. Immunol., 121, 464-470. https://doi.org/10.1016/j.jaci.2007.09.018
  13. Kremmyda, L.S., Vlachava, M., Noakes, P.S., Diaper, N.D., Miles, E.A. and Calder, P.C. (2011). Atopy risk in infants and children in relation to early exposure to fish, oily fish, or long-Chain Omega-3 fatty acids: A systematic review. Clin. Rev. Allergy Immunol., 41, 36-66. https://doi.org/10.1007/s12016-009-8186-2
  14. Kwon, D.Y., Daily, J.W. 3rd., Kim, H.J. and Park, S. (2010). Antidiabetic effects of fermented soybean products on type 2 diabetes. Nutr. Res., 30, 1-13. https://doi.org/10.1016/j.nutres.2009.11.004
  15. Leitges, M., Gimborn, K., Elis, W., Kalesnikoff, J., Hughes, M.R., Krystal, G. and Huber, M. (2002). Protein kinase C-delta is a negative regulator of antigen-induced mast cell degranulation. Mol. Cell Biol., 22, 3970-3980. https://doi.org/10.1128/MCB.22.12.3970-3980.2002
  16. Leung, D.Y., Boguniewicz, M., Howell, M.D., Nomura, I. and Hamid, Q.A. (2004). New insights into atopic dermatitis. J. Clin. Invest., 113, 651-657. https://doi.org/10.1172/JCI21060
  17. Levin, T.A., Ownby, D.R., Smith, P.H., Peterson, E.L., Williams, L.K., Ford, J., Young, P. and Johnson, C.C. (2006). Relationship between extremely low total serum IgE levels and rhinosinusitis. Ann. Allergy Asthma Immunol., 97, 650-652. https://doi.org/10.1016/S1081-1206(10)61095-2
  18. Li, C., Lasse, S., Lee, P., Nakasaki, M., Chen, S.W., Yamasaki, K., Gallo, R.L. and Jamora, C. (2010). Development of atopic dermatitis- like skin disease from the chronic loss of epidermal caspase-8. Proc. Natl. Acad. Sci. U.S.A., 107, 22249-22254. https://doi.org/10.1073/pnas.1009751108
  19. Li, M., Messaddeq, N., Teletin, M., Pasquali, J.L., Metzger, D. and Chambon, P. (2005). Retinoid X receptor ablation in adult mouse keratinocytes generates an atopic dermatitis triggered by thymic stromal lymphopoietin. Proc. Natl. Acad. Sci. U.S.A., 102, 14795-14800. https://doi.org/10.1073/pnas.0507385102
  20. Nystad, W., Roysamb, E., Magnus, P., Tambs, K. and Harris, J.R. (2005). A comparison of genetic and environmental variance structures for asthma, hay fever and eczema with symptoms of the same diseases: A study of norwegian twins. Int. J. Epidemiol., 34, 1302-1309. https://doi.org/10.1093/ije/dyi061
  21. Ouyang, W., Ranganath, S.H., Weindel, K., Bhattacharya, D., Murphy, T.L., Sha, W.C. and Murphy, K.M. (1998). Inhibition of Th1 development mediated by GATA-3 through an IL-4- independent mechanism. Immunity, 9, 745-755. https://doi.org/10.1016/S1074-7613(00)80671-8
  22. Romagnani, S. (2000). The role of lymphocytes in allergic disease. J. Allergy Clin. Immunol., 105, 399-408. https://doi.org/10.1067/mai.2000.104575
  23. Schwartz, L.B. (2004). Effector cells of anaphylaxis: Mast cells and basophils. Novartis Found Symp., 257, 65-74. https://doi.org/10.1002/0470861193.ch6
  24. Seki, H., Sasaki, T., Ueda, T. and Arita, M. (2010). Resolvins as Regulators of the immune system. ScientificWorldJournal, 4, 818-831.
  25. Soumelis, V., Reche, P.A., Kanzler, H., Yuan, W., Edward, G., Homey, B., Gilliet, M., Ho, S., Antonenko, S., Lauerma, A., Smith, K., Gorman, D., Zurawski, S., Abrams, J., Menon, S., McClanahan, T., de Waal-Malefyt Rd, R., Bazan, F., Kastelein, R.A. and Liu, Y.J. (2002). Human epithelial cells trigger dendritic cell mediated allergic inflammation by producing TSLP. Nat. Immunol., 3, 673-680. https://doi.org/10.1038/nrm910
  26. Stone, K.D., Prussin, C. and Metcalfe, D.D. (2010). IgE, mast cells, basophils, and eosinophils. J. Allergy Clin. Immunol., 125, S73-S80. https://doi.org/10.1016/j.jaci.2009.11.017
  27. Szabo, S.J., Kim, S.T., Costa, G.L., Zhang, X., Fathman, C.G. and Glimcher, L.H. (2000). A novel transcription factor, T-Bet, directs Th1 lineage commitment. Cell, 100, 655-669. https://doi.org/10.1016/S0092-8674(00)80702-3
  28. Uchida, M., Shimizu, K. and Kurakazu, K. (2010). Yogurt containing lactobacillus gasseri OLL 2716 (LG21 Yogurt) accelerated the healing of acetic acid-induced gastric ulcer in rats. Biosci. Biotechnol. Biochem., 74, 1891-1894. https://doi.org/10.1271/bbb.100287
  29. Wahlgren, C.F. (1999). Itch and atopic dermatitis: An overview. J. Dermatol., 26, 770-779. https://doi.org/10.1111/j.1346-8138.1999.tb02090.x
  30. Zheng, W. and Flavell, R.A. (1997). The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell, 89, 587-596. https://doi.org/10.1016/S0092-8674(00)80240-8

피인용 문헌

  1. External Application of Apo-9'-fucoxanthinone, Isolated from Sargassum muticum, Suppresses Inflammatory Responses in a Mouse Model of Atopic Dermatitis vol.32, pp.2, 2016, https://doi.org/10.5487/TR.2016.32.2.109
  2. vol.33, pp.4, 2017, https://doi.org/10.5487/TR.2017.33.4.325