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Antioxidant and Anticancer Activities of Yak-Sun Tea Prepared by Oriental Medicinal Herbs

한방생약재를 이용한 약선차의 항산화 및 항암효과

  • Choi, Il-Sook (Dept. of Food and Nutrition, KyungHee University) ;
  • Cha, Eun-Jung (Culinary School of Korea History and Culture) ;
  • Lee, Youn-Ri (Dept. of Food and Nutrition, DaeJeon Health Sciences College) ;
  • Kim, Jae-Keun (School of Food, Nutrition and Cookery, KeiMyung College)
  • 최일숙 (경희대학교 식품영양학과) ;
  • 차은정 (한국역사문화음식학교) ;
  • 이연리 (대전보건대학 식품영양학과) ;
  • 김재근 (계명문화대학 식품영양조리학부)
  • Received : 2012.06.07
  • Accepted : 2012.06.25
  • Published : 2012.09.30

Abstract

Various types of tea are consumed as a popular beverage worldwide particularly in Asian countries such as Korea, China, and Japan. The purpose of this study was to investigate the mineral contents, antioxidant properties and anticancer activity of Yak-Sun tea that is prepared by six oriental medicinal herbs. The results of the mineral contents were as follows; Ca, Mg, and Na contents were higher than those of green tea, whereas Fe, P, and K contents were lower than those of green tea. The total phenolics and flavonoid content of the Yak-Sun tea were higher than those of green and black teas. The $IC_{50}$ values of DPPH radical, hydroxyl radical, hydrogen peroxide radical scavenging of Yak-Sun tea were 0.78, 1.58, and 2.04 $mg/m{\ell}$, respectively, whereas the radical scavenging values of ${\alpha}$-tocopherol was 0.06, 0.05, and 0.09 $mg/m{\ell}$, respectively. When cancer cells were treated with Yak-Sun tea, the anticancer activity increased in a dose dependent manner. HCT116 colon cancer cell lines were dramatically increased, as compared to other cancer cell lines, such as MCF-7, H460, and MKN45 cell lines. The results of this study demonstrated that Yak-Sun tea could function as a tea to enhance health conditions for antioxidant and anticancer activity.

Keywords

References

  1. Amerine MA, Ough CS. 1980. Method for Analysis of Musts and Wine. John Wiley and Sons, New York. pp. 176-180
  2. An DH, Cho SJ, Jung ES, Lee HJ, Hwang JH, Park E, Lee SC. 2006. Antioxidant and anticancer activities of water extrats from Ceramium kondoi. J Korean Soc Food Sci Nutr 35:1304-1308 https://doi.org/10.3746/jkfn.2006.35.10.1304
  3. AOAC. 1995. Official Methods of Analysis. 16th ed. Method 935.29. Association of Offical Analytical Chemists, Washington DC, USA
  4. Blios MS. 1958. Antioxidant determinations by the use of a stable free radical. Nature 26:1199-1200
  5. Brand-Williams W, Cuvelier ME, Berset C. 1995. Use of a free-radical method to evaluate antioxidant activity. LWT 28:25-30 https://doi.org/10.1016/S0023-6438(95)80008-5
  6. Choi IS, Kim KA, Yim JE, Kim YS. 2011a. Calorie restriction and obesity under the regulation of SIRT1. Korean J Obes 20:170-176 https://doi.org/10.7570/kjo.2011.20.4.170
  7. Choi JM, Kim KY, Lee SH, Ahn JB. 2011b. Functional propterties of water extracts from different parts of Acanthopanax sessiliflorus. Food Eng Progr 15:130-135
  8. Choi Y, Kim MH, Shin JJ, Park JM, Lee J. 2003. The antioxidant activities of the some commercial teas. J Korean Soc Food Sci Nutr 32:723-727 https://doi.org/10.3746/jkfn.2003.32.5.723
  9. Do JR, Kim KJ, Jo JH, Kim YM, Kim BS, Kim HK, Lim SD, Lee SW. 2005. Antimicrobial, antihypetensive and anticancer activities of medicinal herbs. Korean J Food Sci Technol 37:206-213
  10. Gallaher RN, Gallaher K, marshall AJ, Marshall AC. 2006. Mineral analysis of ten types of commercially available tea. Food Compos Anal 19:S53-S57 https://doi.org/10.1016/j.jfca.2006.02.006
  11. Halliwell B, Gutteridge JM, Grootveld M. 1987. Methods for the measurement of hydroxyl radicals in biochemical systems: deoxyribose degradation and aromatic hydroxylation. Methods Biochem Anal 33:59-90
  12. Han JH, Par SN, Yoon MS, Choi OB. 2011. Effects of Houttuynia cordaata Thunb extract inhibits on the migration and proliferation of vascular smooth muscle cell. Kor J Pharmacogn 42:182-186
  13. Hwang KM, Oh SH, Park KY. 2007. Increased antimutagenic and in vitro anticaner effects by adding green tea extract and bamboo salt during Doenjang fermentation. J Korean Soc Food Sci Nutr 36:1-7 https://doi.org/10.3746/jkfn.2007.36.1.001
  14. Ishiyanma M, Tominaga H, Shiga M, Sasamoto K, Ohkura Y, Ueno KA. 1996. Combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazoliumsalt, neutral red and ceystal violet. Biol Pharm Bull 19:1518-1520 https://doi.org/10.1248/bpb.19.1518
  15. Ismail A, Marjan ZM, Foong CW. 2004. Total antioxidant activity and phenolic content in selected vegetables. Food Chem 87:581-586 https://doi.org/10.1016/j.foodchem.2004.01.010
  16. Jang JH, Choi HS, Cheong HS, Kang OJ. 2007. A comparison of the antioxidant activity of barely leaf tea and green tea according to leaching conditions in distilled water. Korean J Food Cookery Sci 2:165-127
  17. Joo SJ, Choi KJ, Kim KS, Park SG, Kim TS, Oh MH, Lee SS, Ko JW. 2002. Characteristics of mixed tea prepared with several herbs cultivated in Korea. Korean J Food Preserv 9:400-405
  18. Ju JC, Shin JH, Lee SJ, Cho HS, Sung NJ. 2006. Antioxidative activity of hot water extracts from medicinal plants. J Korean Soc Food Sci Nutr 35:7-14 https://doi.org/10.3746/jkfn.2006.35.1.007
  19. Kawaguchi K, Mizuno T, Aida K, Uchino K. 1997. Hesperidin as an inhibitor of lipases from porcine pancreas and Pseudomonas. Biosci Biotechnol Biochem 61:102-104 https://doi.org/10.1271/bbb.61.102
  20. Kim JG, Kang YM, Eum GS, Ko YM, Kim TY. 2003. Antioxidative activity and antimicrobial activity of extracts from medicinal plants. J Agricul & Life Sci 37:69-75
  21. Kim SJ, Kweon DH, Lee JH. 2006. Investigation of antioxidative activity and stability of ethanol extracts of licoriceroot (Glycyrrhiza glabra). Korean J Food Sci Technol 38:584-599
  22. Kim TS, Park WJ, Kos SB, Kang MH. 2008. Development of extracts of Lycii folium having high antioxidant activity. J Korean Soc Food Sci Nutr 37:1318-1322 https://doi.org/10.3746/jkfn.2008.37.10.1318
  23. Koh MS. 2004. Antimicrobial activity of Saururus chinensis Baill extract. J Korean Soc Food Sci Nutr 33:1098-1150 https://doi.org/10.3746/jkfn.2004.33.7.1098
  24. Lee GD, Yoon SR, Kim JO, Hur SS, Seo KI. 2004. Monitoring on the tea with steaming and drying process of germinated buckwheat. J Korean Soc Food Sci Nutr 33:212-217 https://doi.org/10.3746/jkfn.2004.33.1.212
  25. Masahiro O, Midori H, Kumiko S, Shro U, Toyoshige E. 1970. Antioxidant activity of magnolol, honokiol and relatedphenolic compounds. JAOCS 74:557-562
  26. Muuller HE. 1995. Detection of hydrogen peroxide proceeds by microorganism on ABTS-peroxidase medium. Zentalbl Bakteriol Mikrobiol Hyg 259:151-158
  27. Nordberg J, Arner ESJ. 2003. Reactivitie oxygen species, antioxidants and the mammalian thioredoxin system. Free Radical Bio Med 31:1287-1312
  28. Shen Y, Jin L, Xiao P, Lu Y, Bao J. 2009. Total phenolics, flavonoids, antioxidant capacity in rice grain and their relations to grain color, size, and weight. J Cereal Sci 49:106-111 https://doi.org/10.1016/j.jcs.2008.07.010
  29. Son KH, Hqang JH, Lee SH, Park JH, Kang SJ, Chang SY, Lee KS. 1999. Isolation and quantitative determinaton of 20-hydroxyecdysone from Achranthis radix. Kor J Pharmacogn 30:335-339
  30. Son KH, Seo JH, Joo ML, Kwon SJ, Chang SY, Lee KS. 2001. Isolation and quantitative determination of dioscin from Smilacis chinae Radix. Kor J Pharmacogn 32:153-156
  31. Wang YM, Chen CX, Ji M, Lin KH. 1986. A study of pharmacological actions of flos Acanthopanacis senticosi. J Tradit Chin Med 6:297-300
  32. Yoo KM, Kim CE, Kim DI, Huh D, Hwang IK. 2005. Antioxidant activity and physicochemical characteristics of tangerine peel tea with Citrus unshiu cultivated in Cheju. Korean J Food Cookery Sci 21:354-359
  33. 박종희, 이정규. 2000. 상용약용식물도감. 도서출판 신일상사. p.450
  34. 염태환, 박성수. 2005. 현대한방강좌. 행림출판, 서울. pp.451-478
  35. 이재희. 2001. 도설한방진료요방. 의학연구사, 서울. pp.393-636

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