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Safe Nuclear Factor-kappa B Inhibitor for Cachexia Management

악액질 완화를 위한 안전한 Nuclear Factor-kappa B 전사인자 제어 물질 발굴

  • Park, Jeong-Soo (Department of Biochemistry, Dankook University College of Medicine)
  • 박정수 (단국대학교 의과대학 생화학교실)
  • Received : 2012.07.02
  • Accepted : 2012.07.19
  • Published : 2012.08.31

Abstract

Purpose: Cachexia is a complex metabolic syndrome associated with wasting of skeletal muscle which contributes to nearly one-third of all cancer deaths. Cachexia lowers the frequency of response to chemotherapy and radiation and ultimately can impact survival as well as quality of life during treatment. NF-kappa B is one of the most important molecular mediators of cachexia. In this study, therefore, possible candidates for inhibitors of NF-kappa B were searched. Methods: Amino acids that regulate cellular redox potential by adjusting the level of NAD/NADH ratio, such as aspartate, pyruvate, and isocitrate were selected. Results: Pyruvate effectively inhibited luciferase activity in TNF-stimulated 293T cells transfect with an NF-kB dependent luciferase reporter vector. Pyruvate also showed protective effect on muscle atrophy of differentiated C2C12 myocyte induced by TNF/IFN. Conclusion: We might be able to develop the nutritional management strategy for cancer cachexia patients with pyruvate supplementation.

Acknowledgement

Supported by : 단국대학교

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