Asian Pacific Journal of Cancer Prevention

  • 제13권6호
  • /
  • Pages.2533-2539
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Chemopreventive Potential of Annona Muricata L Leaves on Chemically-Induced Skin Papillomagenesis in Mice

  • Hamizah, Sulaiman (Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia) ;
  • Roslida, A.H. (Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia) ;
  • Fezah, O. (Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia) ;
  • Tan, K.L. (Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia) ;
  • Tor, Y.S. (Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia) ;
  • Tan, C.I. (Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Universiti Putra Malaysia)
  • 발행 : 2012.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Annona muricata L (Annonaceae), commonly known as soursop has a long, rich history in herbal medicine with a lengthy recorded indigenous use. It had also been found to be a promising new anti-tumor agent in numerous in vitro studies. The present investigation concerns chemopreventive effects in a two-stage model of skin papillomagenesis. Chemopreventive effects of an ethanolic extract of A. muricata leaves (AMLE) was evaluated in 6-7 week old ICR mice given a single topical application of 7,12-dimethylbenza(${\alpha}$)anthracene (DMBA 100ug/100ul acetone) and promotion by repeated application of croton oil (1% in acetone/twice a week) for 10 weeks. Morphological tumor incidence, burden and volume were measured, with histological evaluation of skin tissue. Topical application of AMLE at 30, 100 and 300mg/kg significantly reduced DMBA/croton oil induced mice skin papillomagenesis in (i) peri-initiation protocol (AMLE from 7 days prior to 7 days after DMBA), (ii) promotion protocol (AMLE 30 minutes after croton oil), or (iii) both peri-initiation and promotion protocol (AMLE 7 days prior to 7 day after DMBA and AMLE 30 minutes after croton oil throughout the experimental period), in a dose dependent manner (p<0.05) as compared to carcinogen-treated control. Furthermore, the average latent period was significantly increased in theAMLE-treated group. Interestingly, At 100 and 300 mg/kg, AMLE completely inhibited the tumor development in all stages. Histopathological study revealed that tumor growth from the AMLE-treated groups showed only slight hyperplasia and absence of keratin pearls and rete ridges. The results, thus suggest that the A.muricata leaves extract was able to suppress tumor initiation as well as tumor promotion even at lower dosage.

키워드

참고문헌

  1. Anand P, Sundaram C, Jhurani S, et al (2008). Curcumin and cancer: An "old age" disease with an "age-old" solution. Cancer Lett, 267, 133-64. https://doi.org/10.1016/j.canlet.2008.03.025
  2. Antoun MD, Gerena L, Milhus WK (1993). Screening of the flora of puerto rico for potential antimalarial bioactives. Int J Pharmacol, 31, 255-8. https://doi.org/10.3109/13880209309082950
  3. Arkcoll D (1990). New crops from Brazil In Janick J, Simon JE (eds.), Advances in new crops. timber press, Portland.
  4. Baskar R, Rajeswari V, Kumar TS (2007). In vitro antioxidant studies in leaves of annona species. Indian J Exp Biol, 4, 480-5.
  5. Chang FR, Liaw CC, Lin CY, et al (2003). New adjacent bistetrahydrofuran annonaceous acetogenins from annona muricata. Planta Med, 69, 241-6. https://doi.org/10.1055/s-2003-38485
  6. Cragg GM, Newman DJ (2000). Antineoplastic agents from natural sources: achievement and future directions. Exp Opin Invest Drugs, 9, 1-15.
  7. Das RK, Hossain USK, Bhattacharya S (2005). Diphenylmethy selenocynate inhibits DMBA-croton oil induced two-stage mouse skin carcinogenesis by inducing apoptosis and inhibiting cutaneous cell proliferation. Cancer Lett, 230, 90-101. https://doi.org/10.1016/j.canlet.2004.12.021
  8. De Feo V (1992). Medicinal and magical plants in the Northern Peruvian Andes. Fitoterapia, 63, 417-40.
  9. De Sousa OV, Vieira GDV, De Pinho JJRG, et al (2010). Antinociceptive and anti-inflammatory activities of the ethanol extract of annona muricata L. Leaves in animal models. Int J Mol Sci, 1, 2067-78.
  10. Deo SV, Hazarika S, Shukla NK, et al (2005). Surgical management of skin cancers: Experience from a regional cancer centre in North India. Indian J Cancer, 42, 145-50. https://doi.org/10.4103/0019-509X.17059
  11. Duvoix A, Blasius R, Delhalle S, et al (2005). Chemopreventive and therapeutic effects of curcumin. Cancer Lett, 223, 181-90. https://doi.org/10.1016/j.canlet.2004.09.041
  12. Diepgen TL, Mahler V (2002).The epidemiology of skin cancer. Br J Dermatol, 146, 1-6.
  13. Eisenberg DM, Davis RB, Ettner SL, et al (1998). Trends in alternative medicine use in the United States, 1990-1997: results of a follow-up national survey. J Am Med Assoc, 280, 1569-75. https://doi.org/10.1001/jama.280.18.1569
  14. Geesin JG, Gordon JS, Berg RA (1990). Retinoids affect collagen synthesis through inhibition of ascorbate-induced lipid peroxidation in cultured human dermal fibroblast. Arch Biochem Biophys, 278, 350-5. https://doi.org/10.1016/0003-9861(90)90270-9
  15. Gills JJ, Jeffery EH, Mathsheski NV, et al (2005). Sulforaphane prevents mouse skin tumorigenesis during the stage of promotion. Cancer Lett, 236, 72-9.
  16. Girit IC, Jure-Kunkl M, McIntyre KW (2008). A structured light-based system for scanning subcutaneous tumors in laboratory animals. Comp Med, 58, 264-70.
  17. Heinrich M, Kuhnt M, Wright CW, et al (1992). Parasitological and microbiological evaluation of mixe Indian medicinal plants (Mexico). J Ethnopharmacol, 36, 81-5. https://doi.org/10.1016/0378-8741(92)90063-W
  18. Javed S, Mehrotra NK, Shukla Y (1998). Chemopreventive effects of black tea polyphenols in mouse skin model of carcinogenesis. Biomed Environ Sci, 11, 307-13.
  19. Jemal A, Murray T, Samuels A, et al (2003). Cancer statistics. CA: A Cancer Journal for Clinicians. 53, 5-26. https://doi.org/10.3322/canjclin.53.1.5
  20. Kandaswami C, Middleton E (1994). Free radical scavenging and anti-oxidant activity of plant flavonoids. Adv Exp Med Biol, 366, 351-76. https://doi.org/10.1007/978-1-4615-1833-4_25
  21. Kapadia GJ, Azuine MA, Takiyasu J, et al (2000). Inhibition of epstein-barr virus early antigen activation promoted by 12-O-tetradecanoylphorbol-13-acetate by the non-steroidal anti-inflammatory drugs. Cancer Lett, 161, 221-9. https://doi.org/10.1016/S0304-3835(00)00616-9
  22. Karim-Kos HE, de Vries E, Soerjomataram I, et al (2008). Recent trends of cancer in Europe: a combined approach of incidence, survival and mortality for 17 cancer sites since the 1990s. Eur J Cancer, 44, 1345-89. https://doi.org/10.1016/j.ejca.2007.12.015
  23. Kelloff GJ (2000). Perspectives on cancer chemoprevention research and drug development. Adv Cancer Res, 78, 199-334.
  24. Kim GS, Zeng L, Alali F, et al (1998). Two new monotetrahydrofuran ring acetogenins, annomuricin E and muricapentocin, from the leaves of annona muricata. J Nat Prod, 61, 432-6. https://doi.org/10.1021/np970534m
  25. Kim GS, Zeng L, Alali F, et al (1998). Muricoreacin and murihexocin C, mono-tetrahydrofuran acetogenins, from the leaves of Annona muricata. Phytochem, 49, 565-71. https://doi.org/10.1016/S0031-9422(98)00172-1
  26. Kojima N, Morioka T, Urabe D, et al (2010). Convergent synthesis of fluorescence-labeled probes of annonaceous acetogenins and visualization of their cell distribution. Bioorg Medicinal Chem, 18, 8630-41. https://doi.org/10.1016/j.bmc.2010.10.004
  27. Kossouoh C, Moudachirou M, Adjakidje V, et al (2007). Essential oil chemical composition of annona muricata L. leaves from benin. J Essent Oil Res, 19, 307-9 https://doi.org/10.1080/10412905.2007.9699288
  28. Lans CA (2006). Ethnomedicines used in trinidad and tobago for urinary problems and diabetes mellitus. J Ethnobiol Ethnomedicine, 2, 45-55. https://doi.org/10.1186/1746-4269-2-45
  29. Luna JS, Carvalho JM, Lima MR, et al (2006). Acetogenins in annona muricata L. (annonaceae) leaves are potent molluscicides. Nat Prod Res, 20, 253-7. https://doi.org/10.1080/14786410500161445
  30. Leboeuf M, Legueut C, Cavé A, et al (1981). Alkaloids of annonaceae. XXIX. Alkaloids of annona muricata. Planta Med, 42, 37-44. https://doi.org/10.1055/s-2007-971543
  31. Leboeuf M, Cave A, Bhaumik PK, et al (1982). The phytochemistry of the annonaceae. Phytochem, 21, 2783-813.
  32. Lopez LM, Martin CC, Bermejo A, et al (2001). Cytotoxic compounds from annonaceous species as DNA topoisomerase I poisons. Anticancer Res, 21, 3493-7.
  33. Marx JL (1987). Oxygen free radicals linked to many diseases. Science, 235, 529. https://doi.org/10.1126/science.3810154
  34. Misas C, Hernandez N, Abraham A (1979). Contribution to the biological evaluation of cuban plants. Rev Cubana Med Trop, 31, 29-35.
  35. Oberlies NH, Jones JL, Corbett TH, et al (1995). Tumor cell growth inhibition by several annonaceous acetogenins in an in vitro disk diffusion assay. Cancer Lett, 96, 55-2. https://doi.org/10.1016/0304-3835(95)92759-7
  36. Pandey S, Sharma M, Chaturvedi P, et al (1994). Protective effect of Rubia cordifolia on lipid peroxide formation in isolated rat liver homogenate. Indian J Exp Biol, 32, 180-3.
  37. Pelissler Y, Marion C, Kone D, et al (1994). Volatile components of annona muricata L. J Essent Oil Res, 6, 411-4. https://doi.org/10.1080/10412905.1994.9698410
  38. Rieser MJ, Fang XP, Rupprecht K, et al (1993). Bioactive singlering acetogenins from seed extracts of annona muricata. Planta Med, 59, 91-2. https://doi.org/10.1055/s-2006-959614
  39. Roslida AH, Tay CE, Zuraini A, et al (2010). Anti-inflammatory and anti-nociceptive activities of the ethanolic extract of annona muricata leaf. J Nat Remedies, 10, 97-104.
  40. Sanja G, Mukhtar J (2002). Chemoprevention of Skin Cancer: current status and future prospects. Cancer Metastasis Rev, 21, 363-80. https://doi.org/10.1023/A:1021275330385
  41. Santos AF, Sant'Ana AEG (2001). Molluscicidal properties of some species of annona. Phytomedicine, 8, 115-20. https://doi.org/10.1078/0944-7113-00008
  42. Sharma P, Parmar J, Verma P, et al (2009). Anti-tumor activity of phyllanthus niruri (a medicinal plant) on chemical-induced skin carcinogenesis in mice. Asia Pacific J Cancer Prev, 10, 1089-94.
  43. Sporn MB (1999). Prevention of cancer in the next millennium. Cancer Res, 59, 4743-801.
  44. Sundarrao K, Burrows I, Kuduk M, et al (1993). Preliminary screening of anti-bacterial and anti-tumor activities of papuan new guinean active medicinal plants. Pharmaceutical Biol, 31, 3-6. https://doi.org/10.3109/13880209309082909
  45. Takao K, Midori T (2000). Anti-tumor-promoting activities (cancer chemopreventive activities) of natural products in atta-ur-rahman (Ed.). Studies Natural Products Chemistry, 24, 215-67. https://doi.org/10.1016/S1572-5995(00)80047-2
  46. Taylor L (2002). Technical data report for graviola, annona muricata. Sage Press. Austin, 10. 1-6.
  47. Tormo JR, Royo I, Gallardo T, et al (2003). In vitro antitumor structure-activity relationships of threo/trans/threo monotetrahydro- furanic acetogenins: correlations with their inhibition of mitochondrial complex I. OncolRes, 14, 147-54.
  48. Wang LQ, Min BS, Li Y, et al (2002). Annonaceous acetogenins from the leaves of annona montana. Bioorg Med Chem, 10, 561-5. https://doi.org/10.1016/S0968-0896(01)00303-0
  49. Wattenberg JW (1990). Inhibition of carcinogenesis by naturally occurring and synthetic compounds In Kuroda Y, Shankel DM, Waters MD (Eds.), Antimutagenesis and anticarcinogenesis, Mechanism II, Plenum publishing corp., New York. 155-166.
  50. Wu FE, Zeng L, Gu ZM, et al (1995). New bioactive monotetrahydrofuran annonaceous acetogenins, annomuricin C and muricatocin C, from the leaves of annona muricata. J Nat Prod, 58, 909-15. https://doi.org/10.1021/np50120a014
  51. Wu FE, Zhao GX, Zeng L, et al (1995). Additional bioactive acetogenins, annomutacin and (2,4-trans and cis)-10Rannonacin- A-ones, from the leaves of annona muricata. J Nat Prod, 58, 1430-7. https://doi.org/10.1021/np50123a015
  52. Wu FE, Gu ZM, Zeng L, et al (1995a). Two new cytotoxic monotetrahydrofuran annonaceous acetogenins, annomuricins A and B, from the leaves of annona muricata. J Nat Prod, 58, 830-6. https://doi.org/10.1021/np50120a002
  53. Yallappu MM, Jaggi M, Jauhan SC (2012). Curcumin nanoformulations; a future nanomedicine for cancer. Drug Discovery Today, 17, 71-80. https://doi.org/10.1016/j.drudis.2011.09.009
  54. Youdim KA, Joseph JA (2001). A possible emerging role of phytochemical in improving age-related neurological dysfunctions- a multiplicity of effects. Free Rad Biol Med, 30, 583-94. https://doi.org/10.1016/S0891-5849(00)00510-4
  55. Yuan SS, Chang HL, Chen HW, et al (2003). Annonacin, a mono-tetrahydrofuran acetogenin, arrests cancer cells at the G1 phase and causes cytotoxicity in a bax- and caspase-3-related pathway. Life Sci, 72, 2853-61. https://doi.org/10.1016/S0024-3205(03)00190-5
  56. Zhao J, Wang J, Chen Y, et al (1999). Anti-tumor-promoting activity of a polyphenolic fraction isolates from grape seeds in the mouse skin two stage initiation-promotion protocol and identification of procyanidin B5-30-gallate as the most effective antioxidant constituent. Carcinogenesis, 20, 1737-45. https://doi.org/10.1093/carcin/20.9.1737
  57. Zeng L, Wu FE, Oberlies NH, et al (1996). Five new monotetrahydrofuran ring acetogenins from the leaves of annona muricata. J Nat Prod, 59, 1035-42. https://doi.org/10.1021/np960447e

피인용 문헌

  1. Antioxidant Properties of Medicinal Plants from Peru vol.04, pp.08, 2013, https://doi.org/10.4236/fns.2013.48A009
  2. Chemopreventive Activity of Turmeric Essential Oil and Possible Mechanisms of Action vol.15, pp.16, 2014, https://doi.org/10.7314/APJCP.2014.15.16.6575
  3. Antiproliferative and Chemopreventive effect of Annona muricata Linn. on Ehrlich ascites carcinoma and Benzo[a]pyrene induced lung carcinoma vol.15, pp.4, 2015, https://doi.org/10.1007/s13596-015-0199-1
  4. Species vol.34, pp.6, 2015, https://doi.org/10.1177/1091581815602252
  5. Characterization and selection of exploitable genetic diversity in soursop (Annona muricata Linn.) accessions based on phenotypic attributes and RAPD markers vol.91, pp.4, 2017, https://doi.org/10.1007/s10457-016-9965-4
  6. Annona muricata (Annonaceae): A Review of Its Traditional Uses, Isolated Acetogenins and Biological Activities vol.16, pp.7, 2015, https://doi.org/10.3390/ijms160715625
  7. Bar-HRM for authenticating soursop (Annona muricata) tea vol.8, pp.1, 2018, https://doi.org/10.1038/s41598-018-31127-9
  8. ): A Comprehensive Mechanistic Review vol.2018, pp.1942-0994, 2018, https://doi.org/10.1155/2018/1826170
  9. Exploring the Leaves of Annona muricata L. as a Source of Potential Anti-inflammatory and Anticancer Agents vol.9, pp.1663-9812, 2018, https://doi.org/10.3389/fphar.2018.00661