Asian Pacific Journal of Cancer Prevention

  • 제13권5호
  • /
  • Pages.2425-2427
  • /
  • 2012
  • /
  • 1513-7368(pISSN)
  • /
  • 2476-762X(eISSN)
아시아태평양암예방학회 (Asian Pacific Journal of Cancer Prevention)
권호 표지
DOI QR코드

DOI QR Code

Ornithine Decarboxylase: A Promising and Exploratory Candidate Target for Natural Products in Cancer Chemoprevention

  • Luqman, Suaib (Molecular Bioprospection Department, Biotechnology Division, CSIR-Central Institute of Medicinal and Aromatic Plants)
  • 발행 : 2012.05.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Ornithine decarboxylase (ODC), the first enzyme in the polyamine biosynthesis, plays an important role in tumor progression, cell proliferation and differentiation. In recent years, ODC has been the subject of intense study among researchers, as a target for anti-cancer therapy and specific inhibitory agents, have the potential to suppress carcinogenesis and find applications in clinical therapy. In particular, it is suggested that ODC is a promising candidate target for natural products in cancer chemoprevention. Future exploration of ornithine decarboxyalse inhitors present in nature may offer great hope for finding new cancer chemporeventive agents.

키워드

참고문헌

  1. Coffino P(2001). Regulation of cellular polyamines by antizyme. Nat Rev Mol Cell Biol, 2, 188-94. https://doi.org/10.1038/35056508
  2. Criss WE (2003), A Review of Polyamines and Cancer. Turk J Med Sci, 33, 195-205.
  3. Fang N, Casida JE (1998). Anticancer action of cube' insecticide: Correlation for rotenoid constituents between inhibition of NADH:ubiquinone oxidoreductase and induced ornithine decarboxylase activities. Proc Natl Acad Sci USA, 95, 3380-4. https://doi.org/10.1073/pnas.95.7.3380
  4. Gerhauser C, Mar W, Lee SK, et al (1995). Rotenoids mediate potent cancer chemopreventive activity through transcriptional regulation of ornithine decarboxylase. Nat Med, 1, 260-6. https://doi.org/10.1038/nm0395-260
  5. Gerhauser C, You M, Liu J, et al (1997). Cancer chemopreventive potential of sulforamate, a novel analogue of sulforaphane that induces phase 2 drug metabolizing enzymes. Cancer Res, 57, 272-8.
  6. Hardin MS, Mader R, Hurta RA (2002). K-FGF mediated transformation and induction of metastatic potential involves altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression-role in cellular invasion. Mol Cell Biochem, 233, 49-56. https://doi.org/10.1023/A:1015554006581
  7. Hurta RA (2000). Altered ornithine decarboxylase and S-adenosylmethionine decarboxylase expression and regulation inmouse fibroblasts transformed with oncogenes or constitutively active mitogen-activated protein (MAP) kinase. Mol Cell Biochem, 215, 81-92. https://doi.org/10.1023/A:1026539414863
  8. Ito A, Shamon LA, Yu B, et al (1998). Antimutagenic constituents of Casimiroa edulis with potential cancer chemopreventive activity. J Agric Food Chem, 46, 3509-16. https://doi.org/10.1021/jf9802373
  9. Kato R, nakadate T, Yamamoto S, et al (1983). Inhibition of 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and ornithine decarboxylase activity by quercetin: possible involvement of lipoxygenase inhibition. Carcinogenisis, 4, 1301-5. https://doi.org/10.1093/carcin/4.10.1301
  10. Kondratyuk TP, Park EJ, Marler LE, et al (2011). Resveratrol derivatives as promising chemopreventive agents with improved potency and selectivity. Mol Nut Food Res, 55, 1249-65. https://doi.org/10.1002/mnfr.201100122
  11. Kubota S, Kiyosawa H, Nomura Y, et al (1997). Ornithine decarboxylase overexpression in mouse 10T/2 fibroblasts: cellular transformation and invasion. J Natl Cancer Inst, 89, 567-71. https://doi.org/10.1093/jnci/89.8.567
  12. LaMuraglia GM, Lacaine F, Malt RA (1986). High ornithine decarboxylase activity and polyamine levels in human colorectal neoplasia. Ann Surg, 204, 89-95. https://doi.org/10.1097/00000658-198607000-00013
  13. Lee SK, Luyengi L, Gerhauser C, et al (1999a). Inhibitory effect of munetone, an isoflavonoid, on 12-O-tetradecanoylphorbol 13-acetate-induced ornithine decarboxylase activity. Cancer Lett, 136, 59-65. https://doi.org/10.1016/S0304-3835(98)00309-7
  14. Lee SK, Pezzuto JM (1999). Evaluation of the potential of cancer chemopreventive activity mediated by inhibition of 12-O tetradecanoyl phorbol 13-acetate-induced ornithine decarboxylase activity. Arch Pharm Res, 22, 559-64. https://doi.org/10.1007/BF02975326
  15. Lee SK, Song L, Mata-Greenwood E, et al (1999b). Modulation of in vitro biomarkers of the carcinogenic process by chemopreventive agents. Anticancer, 19, 35-44.
  16. Luk GD, Casero RA Jr (1987). Polyamines in normal and cancer cells. Adv Enzyme, 26, 91-105. https://doi.org/10.1016/0065-2571(87)90007-0
  17. Maiti A, Cuendet M, Kondratyuk T, et al (2007). Synthesis and cancer chemopreventive activity of Zapotin, a natural product from Casimiroa edulis. J Med Chem, 50, 350-5. https://doi.org/10.1021/jm060915+
  18. McCann PP, Pegg AE (1992). Ornithine decarboxylase as an enzyme target for therapy. Pharmacol Ther, 54, 195-215. https://doi.org/10.1016/0163-7258(92)90032-U
  19. Meyskens FL Jr, Gerner EW (1999). Development of difluoromethylornithine (DFMO) as a chemoprevention agent. Clin Cancer Res, 5, 945-51.
  20. Paz EA, Garcia-Huidobro J, Ignatenkos NA (2011). Polyamines in cancer. Adv Clin Chem, 54, 45-70. https://doi.org/10.1016/B978-0-12-387025-4.00002-9
  21. Pegg AE, Shantz LM, Coleman CS (1995). Ornithine decarboxylase as a target for chemoprevention. J Cell Biochem Suppl, 22, 132-8.
  22. Peralta SA, Gilliard G, Megosh L, et al (1998). Polyamines regulate expression of the neoplastic phenotype in mouse skin. Cancer Res, 58, 1654-9.
  23. Pezzuto JM, Kosmeder JW, Park EJ, et al (2005). Characterization of natural product chemopreventive agents. In Cancer Chemoprevention, Kelloff GJ, Hawk ET, Sigman CC (eds). Humana Press Inc., Totowa, NJ, 2, 3-37.
  24. Ramirez-Mares MV, Chandra S, De Mejia EG (2004). In vitro chemopreventive activity of Camellia sinensis, Ilex paraguariensis and Ardisia compressa tea extracts and selected polyphenols. Mut Res, 554, 53-65. https://doi.org/10.1016/j.mrfmmm.2004.03.002
  25. Shantz LM, Levin VA (2007). Regulation of ornithine decarboxylase during oncogenic transformation: mechanisms and therapeutic potential. Amino Acids, 33, 213-23. https://doi.org/10.1007/s00726-007-0531-2
  26. Shantz LM, Pegg AE (1998). Ornithine decarboxylase induction in transformation by H-Ras and RhoA. Cancer Res, 58, 2748-53.
  27. Sharma S, Stutzman JD, Kelloff GJ, et al (1994). Screening of potential chemopreventive agents using biochemical markers of carcinogenesis. Cancer Res, 54, 5848-55.
  28. Soda K (2011). The mechanisms by which polyamines accelerate tumor spread. J Exp Clin Cancer Res, 30, 95. https://doi.org/10.1186/1756-9966-30-95
  29. Udeani GO, Gerhauser C, Thomas CF, et al (1997). Cancer chemopreventive activity mediated by deguelin, a naturally occurring rotenoid. Cancer Res, 57, 3424-8.
  30. Verma AK (1990). Inhibition of tumor promotion by DL-alpha-diffuoromethylornithine, a specific irreversible inhibitor of ornithine decarboxylase. Basic Life Sci, 52, 195-204.
  31. Verma AK (1992). Ornithine decarboxylase, a possible target for human cancer prevention. In 'Cellular and Molecular Targets for Chemoprevention', Steele VE (eds.), CRC Press, Boca Raton, pp 373-389.
  32. Wei H, Tye L, Bresnick E, et al (1990). Inhibitory effect of apigenin, a plant flavonoid, on epidermal ornithine decarboxylase and skin tumor promotion in mice. Cancer Res, 50, 499-502.

피인용 문헌

  1. Association between the ornithine decarboxylase G316A polymorphism and breast cancer survival pp.1792-1082, 2015, https://doi.org/10.3892/ol.2015.3201
  2. Virtual screening of natural inhibitors targeting ornithine decarboxylase with pharmacophore scaffolding of DFMO and validation by molecular dynamics simulation studies pp.1538-0254, 2018, https://doi.org/10.1080/07391102.2018.1439772