Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prevalence of Depression and its Correlations: a Cross-sectional Study in Thai Cancer Patients

  • Maneeton, Benchalak (Department of Psychiatry, Faculty of Medicine, Chiang Mai University) ;
  • Maneeton, Narong (Department of Psychiatry, Faculty of Medicine, Chiang Mai University) ;
  • Mahathep, Pojai (Department of Psychiatry, Faculty of Medicine, Chiang Mai University)
  • Published : 2012.05.30
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Abstract

Objectives: Depression is common in cancer patients. However, only limited evidence is available for Asian populations. The authors therefore examine the prevalence of depression in Thai patients with cancer. In addition, associated factors were determined. Methods: This cross-sectional study was conducted in cancer patients admitted to a university hospital during December 2006 - December 2007. The Patient Health Questionnaire (PHQ-9) was used to assess all cancer patients. Suicidal risk was assessed by using the Mini-International Neuropsychiatric Interview (MINI) in the module of suicidal risk assessment. Results: Of 108 cancer patients, 29.6 % were diagnosed with a depressive disorder (mild, 14.8 %; moderate, 5.6 %; severe, 9.3 %). However, only 25.0 % of these were recognized as being depressed by the primary physician. According to the MINI., 28.1 % of these depressed cancer patients had a moderate to severe level of suicidal risk. In addition, the findings suggest that increased risk of depression is significantly associated with increased pain score, lower number of cancer treatments (< 2 methods), increased educational duration (>13 years), increased age (> 50 years old) and being female. Conclusions: The prevalence of depression is high in Thai cancer patients. However, depressive disorder in those patients is frequently undiagnosed. It is associated with several factors including pain, a number of cancer treatments, education duration, age and sex. To improve quality of life, increase compliance with treatments and prevent of suicide, screening for depressive disorders in this patient group is strongly recommended.

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References

  1. Bellini M, Capannini D (1994). Increased suicide risk in cancer patients. Minerva Psichiatr, 35,175-86.
  2. Boyd AD, Brown D, Henrickson C, et al (2012). Screening for depression, sleep-related disturbances, and anxiety in patients with adenocarcinoma of the pancreas: a preliminary study. ScientificWorld Journal, 2012, 650707.
  3. Breitbart W, Rosenfeld B, Pessin H, et al (2000). Depression, hopelessness, and desire for hastened death in terminally ill patients with cancer. JAMA, 284, 2907-11. https://doi.org/10.1001/jama.284.22.2907
  4. Caplette-Gingras A, Savard J (2008). Depression in women with metastatic breast cancer: a review of the literature. Palliat Support Care, 6, 377-87. https://doi.org/10.1017/S1478951508000606
  5. Ciaramella A, Poli P (2001). Assessment of depression among cancer patients: the role of pain, cancer type and treatment. Psychooncology, 10, 156-65. https://doi.org/10.1002/pon.505
  6. Ell K, Sanchez K, Vourlekis B, et al (2005). Depression, correlates of depression, and receipt of depression care among low-income women with breast or gynecologic cancer. J Clin Oncol, 23, 3052-60. https://doi.org/10.1200/JCO.2005.08.041
  7. Farriols C, Ferrandez O, Planas J, et al (2012). Changes in the prescription of psychotropic drugs in the palliative care of advanced cancer patients over a seven-year period. J Pain Symptom Manage, 43, 945-52. https://doi.org/10.1016/j.jpainsymman.2011.05.010
  8. Fawzy FI, Fawzy NW, Hyun CS, et al (1993). Malignant melanoma. Effects of an early structured psychiatric intervention, coping, and affective state on recurrence and survival 6 years later. Arch Gen Psychiatry, 50, 681-9. https://doi.org/10.1001/archpsyc.1993.01820210015002
  9. Ganzini L, Goy ER, Dobscha SK (2008). Prevalence of depression and anxiety in patients requesting physicians' aid in dying: cross sectional survey. BMJ, 337, 1682.
  10. Jim HS, Small BJ, Minton S, et al (2012). History of major depressive disorder prospectively predicts worse quality of life in women with breast cancer. Ann Behav Med, 43, 402-8. https://doi.org/10.1007/s12160-011-9333-6
  11. Katz MR, Kopek N, Waldron J, et al (2004). Screening for depression in head and neck cancer. Psychooncology, 13, 269-80. https://doi.org/10.1002/pon.734
  12. Kim JM, Kim SW, Stewart R, et al (2012). Serotonergic and BDNF genes associated with depression 1 week and 1 year after mastectomy for breast cancer. Psychosom Med, 74, 8-15. https://doi.org/10.1097/PSY.0b013e318241530c
  13. Kim SW, Shin IS, Kim JM, et al (2008). Effectiveness of mirtazapine for nausea and insomnia in cancer patients with depression. Psychiatry Clin Neurosci, 62, 75-83. https://doi.org/10.1111/j.1440-1819.2007.01778.x
  14. Kissane D (2009). Beyond the psychotherapy and survival debate: the challenge of social disparity, depression and treatment adherence in psychosocial cancer care. Psychooncology, 18, 1-5. https://doi.org/10.1002/pon.1493
  15. Kroenke K, Spitzer RL, Williams JB (2001). The PHQ-9: validity of a brief depression severity measure. J Gen Intern Med, 16, 606-13. https://doi.org/10.1046/j.1525-1497.2001.016009606.x
  16. Liu DG, Wang SS, Peng RJ, et al (2011). Interaction of social support and psychological stress on anxiety and depressive symptoms in breast cancer patients. Asian Pac J Cancer Prev, 12, 2523-9.
  17. Madeira N, Albuquerque E, Santos T, et al (2011). Death ideation in cancer patients: contributing factors. J Psychosoc Oncol, 29, 636-42. https://doi.org/10.1080/07347332.2011.615381
  18. Massie MJ, Holland JC (1984). Diagnosis and treatment of depression in the cancer patient. J Clin Psychiatry, 45, 25-9.
  19. Mitchell AJ, Lord K, Symonds P (2012). Which symptoms are indicative of DSMIV depression in cancer settings? An analysis of the diagnostic significance of somatic and nonsomatic symptoms. J Affect Disord, 138, 137-48. https://doi.org/10.1016/j.jad.2011.11.009
  20. Palmer SC, Taggi A, Demichele A, et al (2012). Is screening effective in detecting untreated psychiatric disorders among newly diagnosed breast cancer patients? Cancer, 118, 2735-43. https://doi.org/10.1002/cncr.26603
  21. Pirl WF, Greer JA, Traeger L, et al (2012). Depression and survival in metastatic non-small-cell lung cancer: effects of early palliative care. J Clin Oncol, 30, 1310-5. https://doi.org/10.1200/JCO.2011.38.3166
  22. Richardson JL, Shelton DR, Krailo M, et al (1990). The effect of compliance with treatment on survival among patients with hematologic malignancies. J Clin Oncol, 8, 356-64. https://doi.org/10.1200/JCO.1990.8.2.356
  23. Riechelmann RP, Burman D, Tannock IF, et al (2010). Phase II trial of mirtazapine for cancer-related cachexia and anorexia. Am J Hosp Palliat Care, 27, 106-10. https://doi.org/10.1177/1049909109345685
  24. Ruijs CD, Kerkhof AJ, van der Wal G, et al (2011). Depression and explicit requests for euthanasia in end-of-life cancer patients in primary care in the Netherlands: a longitudinal, prospective study. Fam Pract, 28, 393-9. https://doi.org/10.1093/fampra/cmr006
  25. Salvo N, Zeng L, Zhang L, et al (2012). Frequency of reporting and predictive factors for anxiety and depression in patients with advanced cancer. Clin Oncol, 24, 139-48. https://doi.org/10.1016/j.clon.2011.05.003
  26. Serlin RC, Mendoza TR, Nakamura Y, et al (1995). When is cancer pain mild, moderate or severe? Grading pain severity by its interference with function. Pain, 61, 277-84. https://doi.org/10.1016/0304-3959(94)00178-H
  27. Sheehan DV, Lecrubier Y, Sheehan KH, et al (1998). The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10. J Clin Psychiatry, 59, 22-33.
  28. Spiegel D, Bloom JR, Kraemer HC, et al (1989). Effect of psychosocial treatment on survival of patients with metastatic breast cancer. Lancet, 2, 888-91.
  29. Tada Y, Matsubara M, Kawada S, et al (2012). Psychiatric disorders in cancer patients at a university hospital in Japan: descriptive analysis of 765 psychiatric referrals. Jpn J Clin Oncol, 42, 183-8. https://doi.org/10.1093/jjco/hyr200
  30. Thompson DS, Shear MK (1998). Psychiatric disorders and gynecological oncology: a review of the literature. Gen Hosp Psychiatry, 20, 241-7. https://doi.org/10.1016/S0163-8343(98)00030-9
  31. Uchitomi Y, Mikami I, Nagai K, et al (2003). Depression and psychological distress in patients during the year after curative resection of non-small-cell lung cancer. J Clin Oncol, 21, 69-77. https://doi.org/10.1200/JCO.2003.12.139
  32. Walker J, Hansen CH, Butcher I, et al (2011). Thoughts of death and suicide reported by cancer patients who endorsed the "suicidal thoughts" item of the PHQ-9 during routine screening for depression. Psychosomatics, 52, 424-7. https://doi.org/10.1016/j.psym.2011.02.003
  33. Warmenhoven F, van Rijswijk E, van Weel C, et al (2012). Low prevalence of depressive disorder in ambulatory advanced cancer patients using the Schedules for Clinical Assessment in Neuropsychiatry (SCAN 2.1). J Affect Disord, 136, 1209-11. https://doi.org/10.1016/j.jad.2011.11.017
  34. Yoshikawa E (2008). Psychiatric symptom in cancer patients requiring immediate management. Gan To Kagaku Ryoho, 35, 2326-9.
  35. Yu H, Wang Y, Ge X, et al (2012). Depression and survival in Chinese patients with gastric cancer: a prospective study. Asian Pac J Cancer Prev, 13, 391-4. https://doi.org/10.7314/APJCP.2012.13.1.391

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