Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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No Association Between the USP7 Gene Polymorphisms and Colorectal Cancer in the Chinese Han Population

  • Li, Xin (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Wang, Yang (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Li, Xing-Wang (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Liu, Bao-Cheng (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Zhao, Qing-Zhu (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Li, Wei-Dong (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Chen, Shi-Qing (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Huang, Xiao-Ye (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Yang, Feng-Ping (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • Wang, Quan (Department of General Surgery, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University) ;
  • Wang, Jin-Fen (Shanxi Cancer Hospital) ;
  • Xiao, Yan-Zeng (Shanxi Cancer Hospital) ;
  • Xu, Yi-Feng (Shanghai Institute of Mental Health, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University) ;
  • Feng, Guo-Yin (Shanghai Institute of Mental Health, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University) ;
  • Peng, Zhi-Hai (Department of General Surgery, The Affiliated Shanghai First People's Hospital of Shanghai Jiao Tong University) ;
  • He, Lin (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University) ;
  • He, Guang (Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University)
  • Published : 2012.05.30
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Abstract

Colorectal cancer (CRC), now the third most common cancer across the world, is known to aggregate in families. USP7 is a very important protein with an important role in regulating the p53 pathway, which is critical for genomic stability and tumor suppression. We here genotyped eight SNPs within the USP7 gene and conducted a case-control study in 312 CRC patients and 270 healthy subjects in the Chinese Han population. No significant associations were found for any single SNP and CRC risk. Our data eliminate USP7 as a potential candidate gene towards for CRC in the Han Chinese population.

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References

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