Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Preparation and Characterization of Gelatin-immobilized Bacterial Cellulose Scaffold for Tissue Engineering Using Gamma-ray Irradiation

감마선을 이용한 조직공학용 젤라틴이 개질된 미생물 셀룰로오스 지지체의 제작 및 특성

  • Choi, Jong-Bae (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Jeong, Sung In (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Gwon, Hui-Jeong (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Park, Jong-Seok (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Nho, Young-Chang (Research Division for Industry & Environment, Korea Atomic Energy Research Institute) ;
  • Choi, Young-Hun (Citrus Research Station, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Park, Kyung Jin (Citrus Research Station, National Institute of Horticultural and Herbal Science, Rural Development Administration) ;
  • Park, Man Yong (Jadam Co) ;
  • Shin, Heungsoo (Department of Bioengineering, Division of Applied Chemical and Bio Engineering, Hanyang University) ;
  • Lim, Youn-Mook (Research Division for Industry & Environment, Korea Atomic Energy Research Institute)
  • 최종배 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 정성린 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 권희정 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 박종석 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 노영창 (한국원자력연구원 첨단방사선연구소 공업환경연구부) ;
  • 최영훈 (국립원예특작과학원 감귤시험장) ;
  • 박경진 (국립원예특작과학원 감귤시험장) ;
  • 박만용 (주식회사 자담) ;
  • 신흥수 (한양대학교 대학원 생명공학과) ;
  • 임윤묵 (한국원자력연구원 첨단방사선연구소 공업환경연구부)
  • Received : 2012.03.31
  • Accepted : 2012.05.13
  • Published : 2012.06.30

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Abstract

Bacterial cellulose (BC) is generated from citrus gel by Gluconacetobacter hansenii TL-2C. BC has good properties such as high-burst pressure, high-water contact and the ultrafine highly nanofibrous structure of mimic natural extracellular matrix (ECM) for tissue engineering. In this study, acrylic acid (AAc) was grafted onto BC surfaces under aqueous conditions using gamma-ray irradiation, and then immobilized gelatin onto AAc-g-BC. The characterization of scaffolds was performed by scanning electron microscopy (SEM), attenuated total reflectance-Fourier transform infrared spectroscopy (ATR-FTIR), toluidine blue O (TBO) assay. Morphology of gelatin and AAc incorporation onto BC nanofibers did not changed. Our study suggests that gelatin-immobilized BC nanofibers scaffold has a potentiality to fabricate 3D nanofibrous scaffolds for tissue engineering.

Keywords

Acknowledgement

Supported by : 농촌진흥청