Journal of Radiation Industry (방사선산업학회지)

Korean Society of Radiation Industry (한국방사선산업학회)
권호 표지

Reduction of Immune Toxicity of LPS by Gamma Irradiation

감마선 조사에 의한 LPS의 면역 독성 저감화

  • Park, Jong-Heum (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Sung, Nak-Yun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Byun, Eui-Beak (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Song, Du-Sup (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Song, Beom-Seok (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kim, Jaekyung (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Lee, Ju-Woon (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Park, Sang-Hyun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kim, Jae-Hun (Advanced Radiation Technology Institute, Korea Atomic Energy Research Institute) ;
  • Kang, Geon-Ok (Department of Nutrition and Culinary Science, College of Natural Science, Hankyong University) ;
  • Yoo, Young-Choon (Department of Microbiology, College of Medicine, Konyang University)
  • 박종흠 (한국원자력연구원 첨단방사선연구소) ;
  • 성낙윤 (한국원자력연구원 첨단방사선연구소) ;
  • 변의백 (한국원자력연구원 첨단방사선연구소) ;
  • 송두섭 (한국원자력연구원 첨단방사선연구소) ;
  • 송범석 (한국원자력연구원 첨단방사선연구소) ;
  • 김재경 (한국원자력연구원 첨단방사선연구소) ;
  • 이주운 (한국원자력연구원 첨단방사선연구소) ;
  • 박상현 (한국원자력연구원 첨단방사선연구소) ;
  • 김재훈 (한국원자력연구원 첨단방사선연구소) ;
  • 강근옥 (국립한경대학교 자연과학대학 영양조리학과) ;
  • 유영춘 (건양대학교 의과대학 미생물학교실)
  • Received : 2012.07.12
  • Accepted : 2012.08.17
  • Published : 2012.09.30

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Abstract

The purpose of this study is to reduce the immune toxicity of lipopolysaccharide (LPS) by gamma irradiation. LPS was gamma-irradiated at the various doses of 20, 100 and 200 kGy and then evaluated on the immune toxicity through the cell proliferation, nitricoxide production and cytokine release. Cell proliferation significantly decreased in the intact LPS treated groups, whereas gamma-irradiated LPS treated group were not reduced the cell proliferation. Similarly, the production of nitric oxide and cytokine showed the high levels in the intact LPS treated group. However, gamma-irradiated LPS treated group remarkably decreased the production of nitric oxide and cytokine in dose-dependent manner. Therefore, gamma irradiation may effective method to reduce the immune toxicity of LPS.

Keywords

Acknowledgement

Supported by : 한국연구재단