YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effect of Chrysin on Tumor Necrosis Factor-${\alpha}$-induced Mucin Production, Mucin Gene Expression and Translocation of Nuclear Factor-kappa B in Cultured Airway Epithelial Cells

종양괴사인자로 유도된 기도 뮤신 생성, 뮤신 유전자 발현 및 NF-${\kappa}B$ p65의 핵으로의 이동에 대한 크리신의 영향

  • Shin, Hyun-Dae (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Lee, Hyun-Jae (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Sikder, Md. Asaduzzaman (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Ryu, Ji-Ho (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Park, Su-Hyun (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Hong, Jang-Hee (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Seok, Jeong-Ho (Department of Pharmacology, School of Medicine, Chungnam National University) ;
  • Lee, Choong-Jae (Department of Pharmacology, School of Medicine, Chungnam National University)
  • Received : 2012.05.11
  • Accepted : 2012.06.19
  • Published : 2012.06.30
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Abstract

Chrysin and chlorogenic acid are natural products derived from Scutellariae Radix and Lonicerae Flos, respectively. We examined whether chrysin and chlorogenic acid affect airway mucin production induced by TNF-${\alpha}$ in NCI-H292 cells. Cells were pretreated with each agent for 30 min and then stimulated with TNF-${\alpha}$ for 24 h. Of the two compounds, chrysin suppressed airway MUC5AC mucin production. Also, chrysin suppressed MUC5AC mucin gene expression and translocation of NF-${\kappa}B$ p65 induced by TNF-${\alpha}$. This result suggests that chrysin can regulate the production and gene expression of mucin induced by TNF-${\alpha}$ through the inactivation of NF-${\kappa}B$ in airway epithelial cells.

Keywords

References

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