YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Microemulsion Fomulation for Enhanced Topical Absorption of Root Extract of Angelica gigas

당귀 추출물의 피부 흡수 증가를 위한 마이크로에멀젼 조성

  • Jung, Eun-Jae (College of Pharmacy, Seoul National University) ;
  • Choi, Joon-Ho (College of Pharmacy, Seoul National University) ;
  • Park, Chun-Geon (Deparmtment of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Choi, Ae-Jin (Deparmtment of Herbal Crop Research, National Institute of Horticultural & Herbal Science, RDA) ;
  • Jeong, Se-Ho (College of Pharmacy, Seoul National University) ;
  • Chung, Suk-Jae (College of Pharmacy, Seoul National University) ;
  • Shim, Chang-Koo (College of Pharmacy, Seoul National University) ;
  • Kim, Dae-Duk (College of Pharmacy, Seoul National University)
  • 정은재 (서울대학교 약학대학) ;
  • 최준호 (서울대학교 약학대학) ;
  • 박충범 (농촌진흥청 국립원예특작과학원 인삼특작부 약용작물과) ;
  • 최애진 (농촌진흥청 국립원예특작과학원 인삼특작부 약용작물과) ;
  • 정세호 (서울대학교 약학대학) ;
  • 정석재 (서울대학교 약학대학) ;
  • 심창구 (서울대학교 약학대학) ;
  • 김대덕 (서울대학교 약학대학)
  • Received : 2012.03.10
  • Accepted : 2012.05.15
  • Published : 2012.06.30
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Abstract

Angelica gigas is one of the most widely used herbal medicines in Asia. Root extract of Angelica gigas is known to have anti-oxidant activity and skin whitening effect. The aim of this study was to prepare microemulsion system of root extracts of Angelica gigas for topical delivery. Microemulsion was successfully prepared by using MCT (medium chain triglyceride) as an oil phase, Labrasol as a surfactant, and the mixture of propyleneglycol and phosphatidylcholine (4 : 1) as a cosurfactant. In vitro and in vivo skin permeation and deposition of decursin, as a marker, was determined using hairless mouse. Microemulsion significantly increased the in vitro skin permeation of decursin for up to 12 hours and was significantly higher than the control (water). Moreover, microemulsion formulation showed significantly higher skin deposition of decursin compared to the control in both in vitro and in vivo studies. Thus, microemulsion could be a useful vehicle for topical application of root extracts of Angelica gigas.

Keywords

References

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