약학회지 (YAKHAK HOEJI)

  • 제56권2호
  • /
  • Pages.71-73
  • /
  • 2012
  • /
  • 0377-9556(pISSN)
  • /
  • 2383-9457(eISSN)
대한약학회 (The Pharmaceutical Society of Korea)
권호 표지

동충하초에서 분리된 신규 항암물질의 효율적 합성법 개발

Development of an Efficient Synthetic Method for a Novel Anticancer Substance Isolated from Insect-flower

  • 투고 : 2012.02.20
  • 심사 : 2012.03.07
  • 발행 : 2012.04.30
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초록

Cordyceps militaris, a caterpillar-grown traditional medicinal mushroom, produces important bioactive compounds, cordycepin (3'-deoxyadenosine) and militarin. Militarin is reported to possess anticancer activities against several tumor cells. An efficient synthetic method of militarin was developed to prepare muti-gram scale sample for bioassay. Militarin was successfully synthesized from commercial starting materials in 5 steps and 29.3% overall yields.

키워드

참고문헌

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  2. Choi, S. B., Park, C. H., Choi, M. K., Jun, D. W. and Park, S. M. : Improvement of insulin resistance and insulin secretion by water extracts of Cordyceps militaris, Phellinus linteus, and Paecilomyces tenuipes in 90% pancreatectomized rats. Biosci. Biotechnol. Biochem. 68, 2257 (2004).
  3. Yoo, H. S., Shin, J. W., Cho, J. H., Son, C. G., Lee, Y. W., Park, S. Y. and Cho, C. K. : Effect of Cordyceps militaris extract on angiogenesis and tumor growth. Acta Pharmacol. Sin. 25, 657 (2004).
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