Journal of the Korean Society of Food Science and Nutrition (한국식품영양과학회지)

The Korean Society of Food Science and Nutrition (한국식품영양과학회)
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Effect of Polygonum multiflorum Thunberg Extract on Lipid Metabolism in Rats Fed High-Cholesterol Diet

적하수오 추출물이 고콜레스테롤 급여 흰쥐의 지질대사에 미치는 영향

  • Choi, Jun-Hweok (Dept. of Food Science, Keimyung University) ;
  • Lee, Hye-Sung (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Kim, Young-Eon (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Kim, Byoung-Mok (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Kim, In-Ho (Division of Metabolism and Functionality Research, Korea Food Research Institute) ;
  • Lee, Chang-Ho (Division of Metabolism and Functionality Research, Korea Food Research Institute)
  • 최준혁 (계명대학교 식품가공학과) ;
  • 이혜성 (한국식품연구원 대사기능연구본부) ;
  • 김영언 (한국식품연구원 대사기능연구본부) ;
  • 김병목 (한국식품연구원 대사기능연구본부) ;
  • 김인호 (한국식품연구원 대사기능연구본부) ;
  • 이창호 (한국식품연구원 대사기능연구본부)
  • Received : 2012.03.16
  • Accepted : 2012.04.30
  • Published : 2012.07.31
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Abstract

The principal objective of this study was to determine the effects of an ethanol extract of Polygonum multiflorum Thunberg (PMT) on body lipid metabolism in rats fed a high-cholesterol diet for 5 weeks. The rats were divided into 6 groups: a control group (I), a cholesterol-control group (II), a control group treated with 0.5% PMT (III), a control group treated with 1% PMT (IV), a cholesterol-control treated with 0.5% PMT (V), and a cholesterol-control group treated with 1% PMT (VI). Body weight gains and food efficiency ratios were not significantly different among the groups. The levels of serum blood glucose and triglycerides of the treated animals significantly decreased compared to the control and the cholesterol-control groups (p<0.05). There was a clear tendency of decreased LDL-cholesterol level in PMT-treated animals compared to the cholesterol-control group. However, no significant differences were observed in the serum HDL- and LDL-cholesterol levels. In the ratio of HDL-cholesterol to total cholesterol and HDL-cholesterol to LDL-cholesterol concentration, both the 0.5% PMT and 1% PTM extract intake groups had a higher percentage than in the control and cholesterol-control groups (p<0.05). In addition, the atherosclerotic index in serum was significantly lower in the PMT intake group than those in the group control and the cholesterol-control. These results indicated that the PMT extract was effective on the improvement of lipid metabolism in SD rats.

본 실험은 적하수오를 식이에 0.5%, 1% 혼합하여 5주간 섭취시켰을 때 적하수오가 고 콜레스테롤 식이를 장기 급여한 SD rat의 지질대사에 미치는 영향을 확인함으로써 적하수오의 기능성식품 소재로서의 가능성을 확인하였다. 실험기간 중 실험쥐의 체중증가는 1% cholesterol을 첨가한 그룹에서 cholesterol 대조군(II)에 비해서 적하수오를 섭취시킨 V군(1% cholesterol, 0.5% 적하수오), VI군(1% cholesterol, 1% 적하수오)에서 유의적으로 감소하였다. 장기무게는 SD rat의 간 무게가 cholesterol 식이군(II, V, VI) 모두에서 정상식이보다 유의적으로 증가하였으나 신장과 비장의 무게는 유의적인 차이를 나타내지 않았다. 혈청 내 포도당 농도는 정상군과 1% cholesterol 식이군 모두 0.5%, 1% 적하수오를 식이로 섭취시킨 그룹에서 유의적으로 감소하는 경향을 나타냈으며, 총 cholesterol과 HDL-cholesterol, LDL-cholesterol 모두에서 유의적인 차이는 나타나지 않았으나 총 cholesterol과 LDL-cholesterol은 수치상 감소하는 경향을 나타내었다. 하지만 비율로 보았을 때 적하수오를 보충급여한 군의 HDL-cholesterol 비율이 LDL-cholesterol 비율보다 유의적으로 증가하는 경향을 나타냈고 동맥경화지수 또한 적하수오 보충 공급한 그룹에서 낮아지는 것을 확인할 수 있었다. 혈중 중성지방의 농도는 일반식이군과 1% cholesterol 급여군 모두에서 적하수오 추가 급여군이 유의적으로 감소하는 경향을 나타냈고 ALT와 AST 활성은 유의적 차이를 나타내지 않았다. 본 실험의 결과에서 적하수오는 혈청 내 포도당 농도를 유의적으로 감소시켰다. 또한 중성지방의 농도도 유의적으로 감소시켰으며, HDL-cholesterol 비율이 LDL-cholesterol 비율보다 유의적으로 증가하는 경향을 나타냈고, 동맥경화지수 또한 적하수오 보충 공급한 그룹에서 낮아지는 것으로 보아 적하수오가 혈관계 장애로 인해 발병되는 고혈압, 당뇨, 뇌혈관질환, 동맥경화증과 같은 질환을 예방하는데 영향을 미칠 것으로 생각되며 기능성식품소재로서의 가능성이 기대된다.

Keywords

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