Journal of Acupuncture Research

Korean Acupuncture & Moxibustion Medicine Society (대한침구의학회)
권호 표지

The Effect of Ulmus davidiana Planch Pharmacopuncture on Joint Inflammation and Metabolism of Phospholipid in Mice

유근피약침액이 Mouse 관절의 염증과 인지질 활성에 미치는 영향

  • Hwang, Jong-Soon (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Yu-Jong (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Eun-Jung (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Cho, Hyun-Seok (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Lee, Seung-Deok (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kap-Sung (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University) ;
  • Kim, Kyung-Ho (Department of Acupuncture & Moxibustion Medicine, College of Oriental Medicine, Dongguk University)
  • 황종순 (동국대학교 한의과대학 침구학교실) ;
  • 김유종 (동국대학교 한의과대학 침구학교실) ;
  • 김은정 (동국대학교 한의과대학 침구학교실) ;
  • 조현석 (동국대학교 한의과대학 침구학교실) ;
  • 이승덕 (동국대학교 한의과대학 침구학교실) ;
  • 김갑성 (동국대학교 한의과대학 침구학교실) ;
  • 김경호 (동국대학교 한의과대학 침구학교실)
  • Received : 2012.05.09
  • Accepted : 2012.05.21
  • Published : 2012.06.20
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Abstract

Objectives : The purpose of this study was find out the therapeutic effects of Ulmus davidiana Planch pharmacopuncture(UPP) on the mice with collagen-induced rheumatoid arthritis. Methods : UPP was prepared and tested for therapeutic potential of rhematoid arthritis by measuring the inhibition of cyc1ooxgenase-2(COX-2) and phospholipase A2(PLA2) activities in mice. Results : UPP showed therapeutic effects on collagen-induced rheumatoid arthritis on week 8 and week 9. UPP also inhibited Freund's complete adjuvant induced chronic rheumatoid arthritis in mice. UPP showed significant inhibition of type I and type II PLA2 activities in a dose dependent manner. However, PGE2 Production was not decreased with UPP and lipopolysaccharide-induced COX-2 protein expression was not inhibited by UPP. Conclusions : These results suggest that UPP has an therapeutic effects on drug induced-rheumatoic arthritis by inhibiting PLA2 activity.

Keywords

References

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