Biomedical Science Letters (대한의생명과학회지)

The Korean Society for Biomedical Laboratory Sciences (대한의생명과학회)
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A Hydrogel Film Containing Propolis Nanoparticles as a Wound Healing Membrane

  • Kim, Jin (Department of Advanced Chemicals and Engineering, Chonnam National University) ;
  • Kim, Yong-Moon (Department of Advanced Chemicals and Engineering, Chonnam National University) ;
  • Kim, Dong-Woon (Department of Clinical Pathology, Gwangyang Health College) ;
  • Lee, Ki-Young (Faculty of Applied Chemical Engineering, Chonnam National University)
  • Received : 2012.02.27
  • Accepted : 2012.06.04
  • Published : 2012.06.30
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Abstract

It is desirable that a wound healing membrane acts as a barrier for coverage of a damaged skin and has the biological activities such as anti-inflammatory effects. In this study, we prepared the hydrogel film containing the propolis nanoparticles as a wound healing membrane. The propolis nanoparticles were prepared by incorporation of propolis into the hydrophobic core of ${\gamma}$-cyclodextrin. The incorporation efficiency of propolis in the nanoparticles was $50{\pm}2.3%$. Propolis nanoparticles observed by a scanning electron microscope (SEM) were spherical with the size of 30~40 nm. The swelling behaviors of the hydrogel film containing propolis nanoparticles showed a similar pattern with the hydrogel film without propolis nanoparticles. The cumulative amount of propolis released from the hydrogel film containing propolis nanoparticles in the buffer of pH 7.4 and 5.5 was $86.0{\pm}2.0%$ and $64.6{\pm}1.0%$ of total propolis loaded in the hydrogel film within 9 h, respectively. These results provide a rationale for studying wound healing application of the hydrogel film containing propolis nanoparticles in a clinical setting.

Keywords

References

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