KSBB Journal

The Korean Society for Biotechnology and Bioengineering (한국생물공학회)
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Investigation of Cell Behavior on Nanoporous Surface

나노기공 표면에서의 세포 행동양식에 관한 연구

  • Chung, Sung-Hee (Gachon Bio-nano Research Institute, Gachon University) ;
  • Yoon, Won-Jung (Department of Chemical Bioengineering, Gachon University) ;
  • Min, Jun-Hong (Gachon Bio-nano Research Institute, Gachon University)
  • 정성희 (가천대학교 가천바이오나노 연구원) ;
  • 윤원중 (가천대학교 화공생명공학과) ;
  • 민준홍 (가천대학교 가천바이오나노 연구원)
  • Received : 2012.01.03
  • Accepted : 2012.02.09
  • Published : 2012.02.29
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Abstract

In this paper, we investigated the effect of nanostructure on the cell behaviors such as adhesion and growth rate. Nanoporous structures with various diameters (30, 40, 45, 50, 60 nm) and 500 nm of the depth were fabricated using the anodizing method. The water contact angle of the surface consisting of nanopores with 30 nm diameter was 40 degree and those were 60~70 degree in cases of nanopores with over 40 nm diameter. Hela cells were cultivated on various nanoporous structure surface to investigate the cell behavior on nanostructure. As a result, Hela cells preferred 30 nm diameter nanoporous surface that has lower water contact angle. This result was confirmed by protein adsorption experiment and scanning electron microscope investigation.

Keywords

References

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