DOI QR코드

DOI QR Code

In Vitro Activities of Antimicrobials Against Brucella abortus Isolates from Cattle in Korea During 1998-2006

  • Heo, Eun-Jeong (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Kang, Sung-Il (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Kim, Jong-Wan (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Her, Moon (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Cho, Dong-Hee (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Cho, Yun-Sang (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Hwang, In-Yeong (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Moon, Jin-San (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Wee, Sung-Hwan (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Jung, Suk-Chan (Animal, Plant and Fisheries Quarantine and Inspection Agency) ;
  • Nam, Hyang-Mi (Animal, Plant and Fisheries Quarantine and Inspection Agency)
  • 투고 : 2011.09.08
  • 심사 : 2011.11.27
  • 발행 : 2012.04.28

초록

In vitro activities of 13 antibiotics were assessed against 85 Brucella abortus isolates from naturally infected cattle in the Republic of Korea during 1998-2006, using broth microdilution test. Tetracyclines showed the most excellent activity against B. abortus, displaying MIC values of 0.5 ${\mu}g/ml$ or below. In particular, minocycline showed the lowest $MIC_{50/90}$ values (0.125/0.125 ${\mu}g/ml$) in this study. Among four fluoroquinolones tested, ciprofloxacin ($MIC_{50/90}$, 0.5/1 ${\mu}g/ml$) and norfloxacin ($MIC_{50/90}$, 8/8 ${\mu}g/ml$) had the most and the least activities, respectively. Gentamicin ($MIC_{50/90}$, 1/1 ${\mu}g/ml$) was more effective than streptomycin, erythromycin, rifampin, and chloramphenicol ($MIC_{50/90}$, 2/2 ${\mu}g/ml$).

키워드

참고문헌

  1. Al-Tawfiq, J. 2008. Therapeutic options for human brucellosis. Expert Rev. Anti. Infect. Ther. 6: 109-120. https://doi.org/10.1586/14787210.6.1.109
  2. Al Dahouk, S., R. Hagen, K. Nockler, H. Tomaso, M. Wittig, H. Scholz, et al. 2005. Failure of a short-term antibiotic therapy for human brucellosis using ciprofloxacin. Chemotherapy 51: 352-356. https://doi.org/10.1159/000088960
  3. Almuneef, M., Z. Memish, M. Al-Shaalan, E. Al-Banyan, S. Al-Alola, and H. Balkh. 2003. Brucella melitensis bacteremia in children: Review of 62 cases. J. Chemother. 15: 76-80. https://doi.org/10.1179/joc.2003.15.1.76
  4. Ariza, J., M. Bosilkovski, A. Cascio, J. D. Colmenero, M. J. Corbel, M. E. Falagas, et al. 2007. Perspectives for the treatment of brucellosis in the 21st century: The Ioannina recommendations. PLoS Med. 4: 1872-1878
  5. Baykam, N., H. Esener, O. Ergonul, S. Eren, A. K. Celikbas, and B. Dokuzo guz. 2004. In vitro antimicrobial susceptibility of Brucella species. Int. J. Antimicrob. Agents 23: 405-407. https://doi.org/10.1016/j.ijantimicag.2003.09.024
  6. Bodur, H., N. Balaban, S. Aksaray, V. Yetener, E. Akinci, A. Colpan, and A. Erbay. 2003. Biotypes and antimicrobial susceptibilities of Brucella isolates. Scand. J. Infect. Dis. 35: 337-338. https://doi.org/10.1080/00365540310008348
  7. Boschiroli, M., V. Foulongne, and D. O'Callaghan. 2001. Brucellosis: A worldwide zoonosis. Curr. Opin. Microbiol. 4: 58-64. https://doi.org/10.1016/S1369-5274(00)00165-X
  8. Bricker, B. and S. Halling. 1995. Enhancement of the Brucella AMOS PCR assay for differentiation of Brucella abortus vaccine strains S19 and RB51. J. Clin. Microbiol. 33: 1640-1642.
  9. CLSI. 2010. Performance standards for antimicrobial susceptibility testing. M100-S16. Clinical and Laboratory Standards Institute, Wayne, PA, USA.
  10. Dorsch, M., E. Moreno, and E. Stackebrandt. 1989. Nucleotide sequence of the 16S rRNA from Brucella abortus. Nucleic. Acids. Res. 17: 1765. https://doi.org/10.1093/nar/17.4.1765
  11. Ewalt, D. and B. Bricker. 2000. Validation of the abbreviated Brucella AMOS PCR as a rapid screening method for differentiation of Brucella abortus field strain isolates and the vaccine strains, 19 and RB51. J. Clin. Microbiol. 38: 3085-3086.
  12. Garcia-Rodriguez, J., J. Garcia Sanchez, and I. Trujillano. 1991. Lack of effective bactericidal activity of new quinolones against brucella spp. Antimicrob. Agents chemother. 35: 756-759. https://doi.org/10.1128/AAC.35.4.756
  13. Gargani, G. and A. Pacetti. 1986. Sensitivity of 115 strains of the genus Brucella to some antibiotics (cephalosporins, ureidopenicillins and aminoglycosides). Chemioterapia. 5: 7-13.
  14. Hall, W. and R. Manion. 1970. In vitro susceptibility of Brucella to various antibiotics. Appl. Environ. Microb. 20: 600-604.
  15. Hall, W. 1990. Modern chemotherapy for brucellosis in humans. Rev. Infect. Dis. 12: 1060-1099. https://doi.org/10.1093/clinids/12.6.1060
  16. Kim, S. G., Y. H. Kim, M. H. Cho, Y. J. Lee, and C. K. Park. 2009. Biochemical characteristics of Brucella abortus isolated from cattle in Gyungbuk Province. Korean J. Vet. Serv. 32: 139-146.
  17. Lopez-Merino, A., A. Contreras-Rodriguez, R. Migranas-Ortiz, R. Orrantia-Gradin, G. Hernandez-Oliva, A. Gutierrez-Rubio, and O. Cardenosa. 2004. Susceptibility of Mexican Brucella isolates to moxifloxacin, ciprofloxacin and other antimicrobials used in the treatment of human brucellosis. Scand. J. Infect. Dis. 36: 636-638. https://doi.org/10.1080/00365540410020767
  18. Mantur, B. G., S. K. Amamath, and R. S. Shinde. 2007. Review of clinical and laboratory features of human brucellosis. Indian J. Med. Microbiol. 25: 188-202. https://doi.org/10.4103/0255-0857.34758
  19. Marianelli, C., C. Graziani, C. Santagelo, M. T. Xibilia, A. Imbriani, A. Amato, et al. 2007. Molecular epidemiological and antibiotic susceptibility characterization of Brucella isolates from humans in Sicily, Italy. J. Clin. Microbiol. 45: 2923-2928. https://doi.org/10.1128/JCM.00822-07
  20. Marianelli, C., F. Ciuchini, M. Tarantino, P. Pasquali, and R. Adone. 2004. Genetic bases of the rifampin resistance phenotype in Brucella spp. J. Clin. Microbiol. 42: 5439-5443. https://doi.org/10.1128/JCM.42.12.5439-5443.2004
  21. Maves, R. C., R. Castillo, A. Guillen, B. Espinosa, R. Meza, N. Espinoza, et al. 2011. Antimicrobial susceptibility of Brucella melitensis isolates in Peru. Antimicrob. Agents Chemother. 55: 1279-1281. https://doi.org/10.1128/AAC.00979-10
  22. Mortensen, J., D. Moore, J. Clarridge, and E. Young. 1986. Antimicrobial susceptibility of clinical isolates of Brucella. Diagn. Micro. Infect. Dis. 5: 163-169. https://doi.org/10.1016/0732-8893(86)90118-5
  23. Nielsen, K. and J. R. Duncan. 1990. Animal brucellosis. 1st Ed. CRC press.
  24. Park, M. S., Y. S. Woo, M. J. Lee, S. K. Shim, H. K. Lee, Y. S. Choi, et al. 2003. The First Case of Human Brucellosis in Korea. Infect. Chemother. 35: 461-466.
  25. Park, M. Y., C. S. Lee, Y. S. Choi, S. J. Park, J. S. Lee, and H. B. Lee. 2005. A sporadic outbreak of human brucellosis in Korea. J. Korean Med. Sci. 20: 941-946. https://doi.org/10.3346/jkms.2005.20.6.941
  26. Rolain, J., M. Maurin, and D. Raoult. 2000. Bactericidal effect of antibiotics on Bartonella and Brucella spp.: Clinical implications. J. Antimicrob. Chemoth. 46: 811-814. https://doi.org/10.1093/jac/46.5.811
  27. Romero, C., C. Gamazo, M. Pardo, and I. Lopez-Goni. 1995. Specific detection of Brucella DNA by PCR. J. Clin. Microbiol. 33: 615-617.
  28. Shaalan, M., Z. Memish, S. Mahmoud, A. Alomari, M. Khan, M. Almuneef, and S. Alalola. 2002. Brucellosis in children: clinical observations in 115 cases. Int. J. Infect. Dis. 6: 182-186. https://doi.org/10.1016/S1201-9712(02)90108-6
  29. Solera, J., A. Espinosa, E. Martinez-Alfaro, L. Sanchez, P. Geijo, E. Navarro, et al. 1997. Treatment of human brucellosis with doxycycline and gentamicin. Antimicrob. Agents Chemother. 41: 80-84.
  30. Wee, S. H., H. M. Nam, and C. H. Kim. 2008. Emergence of brucellosis in cattle in the Republic of Korea. Vet. Rec. 162: 556-557. https://doi.org/10.1136/vr.162.17.556
  31. WHO. 1986: Joint FAO/WHO Expert Committee on Brucellosis: Sixth report. World Health Organization.

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