Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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A case of canine chondrosarcoma from the rib

늑골에서 발생한 개연골육종의 증례

  • Kim, Sung-Jae (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Kwak, Ho-Hyun (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Park, In-Chul (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Yoon, Byung-Il (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University) ;
  • Han, Jeong-Hee (College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University)
  • 김성재 (강원대학교 수의과대학 동물종합연구소) ;
  • 곽호현 (강원대학교 수의과대학 동물종합연구소) ;
  • 박인철 (강원대학교 수의과대학 동물종합연구소) ;
  • 윤병일 (강원대학교 수의과대학 동물종합연구소) ;
  • 한정희 (강원대학교 수의과대학 동물종합연구소)
  • Received : 2011.03.14
  • Accepted : 2012.06.11
  • Published : 2012.06.30
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Abstract

We report large tumors of the left thoracic cavity, which arose from the ribs, were diagnosed as chondrosarcoma in a 4-year-old male mixed dog. The dog was presented with swelling in the left side of the chest wall and lameness. The masses were found to be circumscribed, whitish-grey, large and firm. The cut surface revealed whitish-grey lobules of varying size with cartilaginous consistency. Those were subsequently metastasized to the lung and mandibular lymph node. Histologically, the tumors were made up of clusters of chondroid cells having pleomorphic hyperchromatic nuclei with occasional mitosis. A special and immunohistochemical staining was performed to confirm the diagnosis. Chondroid matrix in tumor showed a positive reaction for alcian blue-periodic acid-Schiff staining. Immunoreactivity to S-100 proteins was present in the cytoplasm and/or nucleus of chondrocytes in tumor. The final diagnosis was grade III chondrosarcoma in the rib, considering histological features in grading criteria.

Keywords

References

  1. Brodey RS, Misdorp W, Riser WH, van der Heul RO. 1974. Canine skeletal chondrosarcoma: a clinicopathologic study of 35 cases. J Am Vet Med Assoc 165: 68-78.
  2. Brodey RS, Sauer RM, Medway W. 1963. Canine bone neoplasm. J Am Vet Med Assoc 143: 471-495.
  3. Chapman AD, Pritchard SC, Yap WW, Rooney PH, Cockburn JS, Hutcheon AW, Nicolson MC, Kerr KM, McLeod HL. 2001. Primary pulmonary osteosarcoma: case report and molecular analysis. Cancer 91: 779-784. https://doi.org/10.1002/1097-0142(20010215)91:4<779::AID-CNCR1064>3.0.CO;2-J
  4. Hall BK. 1977. Chondrogenesis of the somitic mesoderm. Adv Anat Embryol Cell Biol 53: 3-47.
  5. Indudharan R, Das PK, Azman AA, Suhaiza S. 1998. Chondrosarcoma of the nasal septum. Singapore Med J 39: 376- 379.
  6. Konishi H, Isetani K, Satoh T, Fukuda S, Kodama T, Kashima K. 1994. A case of metastatic chondrosarcoma of the stomach. J Gastroenterol 29: 495-500. https://doi.org/10.1007/BF02361249
  7. Kubo M, Kobayashi K, Masegi T, Sakai H, Tsubota T, Asano M, Itani M, Yanai T. 2007. A case of chondrosarcoma in a free-flying Great Egret. J Wildl Dis 43: 542-544. https://doi.org/10.7589/0090-3558-43.3.542
  8. Lee CH, Choi JH, Choi JH, Kim DY, Yoon JH, Choi MC, Youn HY, Nam TC, Kweon OK. 2000. Primary Rib Chondrosarcoma in a Dog. Korean J Vet Clin Med 17: 261-265.
  9. Liptak JM, Kamstock DA, Dernell WS, Monteith GJ, Rizzo SA, Withrow SJ. 2008. Oncologic outcome after curative-intent treatment in 39 dogs with primary chest wall tumors (1992-2005). Vet Surg 37: 488-496. https://doi.org/10.1111/j.1532-950X.2008.00415.x
  10. Madarame H, Itoh H, Yoshida S, Sakonju I, Takase K, Hasegawa Y. 1998. Canine mesenchymal chondrosarcoma of the ribs. J Vet Med Sci 60: 975-979. https://doi.org/10.1292/jvms.60.975
  11. Matthiesen DT, Clark GN, Orsher RJ, Pardo AO, GlennonL J, Pantnaik AK. 1992. En bloc resection of primary rib tumors in 40 dogs. Vet Surg 21: 201-204. https://doi.org/10.1111/j.1532-950X.1992.tb00046.x
  12. Maxie MG, Youssef S. 2007. Nervous system. pp. 185-281. In: Maxie MG(ed.). Jubb, Kennedy, and Palmer's pathology of domestic animals. 5th ed. Elsevier Saunders, Philadelphia.
  13. Nakamura Y, Becker LE, Marks A. 1983. S‐100 protein in tumors of cartilage and bone: an immunohistochemical study. Cancer 52: 1820-1824. https://doi.org/10.1002/1097-0142(19831115)52:10<1820::AID-CNCR2820521010>3.0.CO;2-3
  14. Okajima K, Honda I, Kitagawa T. 1988. Immunohistochemical distribution of S‐100 protein in tumors and tumor‐like lesions of bone and cartilage. Cancer 61: 792-799. https://doi.org/10.1002/1097-0142(19880215)61:4<792::AID-CNCR2820610425>3.0.CO;2-V
  15. Patnaik AK, Matthiesen DT, Zawie DA. 1988. Two cases of canine penile neoplasm: squamous cell carcinoma and mesenchymal chondrosarcoma. Am Animal Hosp Assoc 24: 403-406.
  16. Pirkey-Ehrhart N, Withrow SJ, Straw RC, Ehrhart EJ, Page RL, Hottinger HL, Hahn KA, Morrison WB, Albrecht MR, Hedlund CS, Hammer AS, Holmberg DL, Moore AS, King RR, Klausen JS. 1995. Primary rib tumors in 54 dogs. J Am Anim Hosp Assoc 31: 65-69. https://doi.org/10.5326/15473317-31-1-65
  17. Popovitch CA, Weinstein MJ, Goldschmidt MH, Shofer FS. 1994. Chondrosarcoma: a retrospective study of 97 dogs (1987- 1990). J Am Anim Hosp Assoc 30: 81-85.
  18. Sylvestre AM, Brash M, Atilola M. 1992. A case series of 25 dogs with chondrosarcoma. Vet Comp Orthop Traumatol 5: 13-17. https://doi.org/10.1055/s-0038-1633124
  19. Thompson KG, Pool RR. 2002. Tumor of bones. pp. 245-318. In: Meuten DJ(ed.). Tumors in domestic animals. 4th ed. Blackwell, Iowa.
  20. Waltman SS, Seguin B, Cooper BJ, Kent M. 2007. Clinical outcome of nonnasal chondrosarcoma in dogs: thirty‐one cases (1986-2003). Vet Surg 36: 266-271. https://doi.org/10.1111/j.1532-950X.2007.00261.x
  21. Weisbrode SE. 2007. Bone and joints. pp. 1041-1094. In: McGavin MD, Zachary JF(ed.). Pathologic basis of veterinary disease. 4th ed. Mosby, Philadelphia.
  22. Withrow SJ, MacEwen EG. 2007. Supportive care for the cancer. pp. 291-346. In: Withrow SJ, MacEwen EG(ed.). Small animal clinical oncology. 2nd ed. Saunders, Philadelphia.