대한환경공학회지 (Journal of Korean Society of Environmental Engineers)

  • 제34권1호
  • /
  • Pages.7-15
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  • 2012
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  • 1225-5025(pISSN)
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  • 2383-7810(eISSN)
대한환경공학회 (Korean Society of Environmental Engineers)
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수유기간에 따른 모유 중 Indicator PCBs 분석을 통한 영유아의 인체노출평가

Estimation of Indicator PCBs Exposure in Infants via Breast-Feeding Period

  • 위성욱 (경남대학교 도시환경공학과) ;
  • 윤조희 (경남대학교 도시환경공학과) ;
  • 민병윤 (경남대학교 도시환경공학과)
  • We, Sung-Ug (Department of Urban Environmental Engineering, Kyungnam University) ;
  • Yoon, Cho-Hee (Department of Urban Environmental Engineering, Kyungnam University) ;
  • Min, Byung-Yun (Department of Urban Environmental Engineering, Kyungnam University)
  • 투고 : 2011.12.08
  • 심사 : 2012.01.12
  • 발행 : 2012.01.31
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초록

Indicator PCB의 농도 수준은 2006년에 세계보건기구(WHO) 프로토콜에 따라 수집된 132개의 모유(초유, 출산 후 30일째 모유, 출산 후 60일째 모유)로 분석하였다. Indicator PCBs의 농도는 고분해능 가스크로마토그래피/고분해능 질량분석기를 이용한 동위원소희석법으로 측정되었으며, 이 방법은 국제적 경향을 비교 평가하기 위한 정확하고 정밀한 데이터를 제공한다. 또한, 모든 분석 결과를 토대로 평균일일섭취량(ADIs)이 계산되었다. 총 indicator PCBs의 중앙값은 14 ng/g lipid로, 다른 나라에서 검출된 농도보다 현저하게 낮았으며, PCBs 138, 153, 180은 분석한 지표 이성질체 합의 약 65%를 차지하였다. 가장 기여율이 높은 PCB 153은 총 indicator PCBs 농도와 매우 높은 상관관계를 나타내었다(p<0.001). PCBs 농도는 산모의 아이수가 증가할수록 확연히 감소하였고, 산모의 PCBs 축적과 배출에 있어 출산경력과 수유기간은 중요한 인자로 나타났다. 6개월 모유수유 기간 동안 총 indicator PCBs의 평균일일섭취량의 중앙값은 $0.077{\mu}g/kg{\cdot}bw/day$이었다. 초산부 모유 중 PCB 118의 농도는 1998년에 비해 25~35% 정도 감소하였으며, 이러한 경향은 지속될 것이라는 것을 보여준다.

The levels of indicator PCBs were determined in 132 human milk samples (Colostrum, 30th days after delivery, 60th days after delivery) collected in 2006 according to World Health Organization's (WHO) protocol. In addition, concentrations of indicator polychlorinated biphenyls (PCBs) were measured by the isotope dilution method with high resolution gas chromatograph/high resolution mass detector (HRGC/HRMS), which gave accurate and precise data for estimations of international trend and comparisons. Average daily intakes (ADIs) of all analytes were calculated. The median level of total indicator PCBs was 14 ng/g lipid, which is significantly lower than the level found in individuals from other countries. PCB congeners 138, 153 and 180 accounted for about 65% of the sum of the indicator congeners analyzed. The concentration of the most abundant PCB 153 is positively correlated with the concentration of the sum indicator PCBs (p<0.001). In this study, concentrations of total indicator PCBs significantly decreased with increasing number of children for a mother, indicating that parity and breast-feeding period an important role in the accumulation and elimination of these compounds in lactating women. The ADI for the median of total indicator PCBs for an infant was evaluated at $0.077{\mu}g/kg{\cdot}bw/day$ from birth to 6 months of age. The present study shows that concentrations of PCB 118 primipara breast milk have decreased 25~35 since 1998, and that this trend is continuing.

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