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Adenocarcinoma of the Lung Progressing to Multiple Cystic Lesions in a 29-Year-Old Man

29세 남자에서 다발성 낭종성 병변으로 진행한 폐선암 1예

  • Lee, Hyun-Seong (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Jeon, Jae-Wan (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Kim, Jae-Hee (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Ju, Hyeong-Uk (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Bae, Joong-Gi (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Min, Young-Ju (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Ahn, Jong-Joon (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Seo, Kwang-Won (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • JeGal, Yang-Jin (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Kwon, Woon-Jung (Department of Radiology, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Cha, Hee-Jeong (Department of Pathology, Ulsan University Hospital, University of Ulsan College of Medicine) ;
  • Ra, Seung-Won (Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine)
  • 이현성 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 전재완 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 김재희 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 주형욱 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 배중기 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 민영주 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 안종준 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 서광원 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 제갈양진 (울산대학교 의과대학 울산대학교병원 내과학교실) ;
  • 권운정 (울산대학교 의과대학 울산대학교병원 영상의학교실) ;
  • 차희정 (울산대학교 의과대학 울산대학교병원 병리학교실) ;
  • 나승원 (울산대학교 의과대학 울산대학교병원 내과학교실)
  • Received : 2011.11.14
  • Accepted : 2011.12.24
  • Published : 2012.02.29

Abstract

Cystic lesions or progressive cystic changes in adenocarcinoma of the lung have rarely been reported. We report a case of lung adenocarcinoma that progressed from ground-glass opacities (GGOs) and consolidations or nodules to extensive cystic lesions during 12 months in a young adult patient. A 29-year-old male was initially diagnosed with primary lung adenocarcinoma by transbronchial lung biopsy of the right lower lobe and lung to lung metastasis in both lungs according to imaging findings. The initial chest computed tomography (CT) scans showed multifocal GGOs, consolidations, and nodules in both lungs. Despite treatment with palliative chemotherapy, the patient's follow-up CT scans showed multiple, cystic changes in both lungs and that the lesions had progressed more extensively. He died of hypoxic respiratory failure one year after his diagnosis.

Keywords

References

  1. Whooley BP, Urschel JD, Antkowiak JG, Takita H. Bronchogenic carcinoma in patients age 30 and younger. Ann Thorac Cardiovasc Surg 2000;6:86-8.
  2. Lee SH, Park SH, Park JH, Lee KE, Park JO, Kim KH, et al. Clinical analysis of primary non-small cell lung cancer in patients younger than 30 years of age. Korean J Intern Med 2002;63 Suppl 1:S146.
  3. Mizushima Y, Yokoyama A, Ito M, Manabe H, Hirai T, Minami H, et al. Lung carcinoma in patients age younger than 30 years. Cancer 1999;85:1730-3. https://doi.org/10.1002/(SICI)1097-0142(19990415)85:8<1730::AID-CNCR12>3.0.CO;2-G
  4. Weisbrod GL, Towers MJ, Chamberlain DW, Herman SJ, Matzinger FR. Thin-walled cystic lesions in bronchioalveolar carcinoma. Radiology 1992;185:401-5. https://doi.org/10.1148/radiology.185.2.1329140
  5. Yoshida T, Harada T, Fuke S, Konishi J, Yamazaki K, Kaji M, et al. Lung adenocarcinoma presenting with enlarged and multiloculated cystic lesions over 2 years. Respir Care 2004;49:1522-4.
  6. Lan CC, Wu HC, Lee CH, Huang SF, Wu YK. Lung cancer with unusual presentation as a thin-walled cyst in a young nonsmoker. J Thorac Oncol 2010;5:1481-2. https://doi.org/10.1097/JTO.0b013e3181e77f2e
  7. Hill CA. Bronchioloalveolar carcinoma: a review. Radiology 1984;150:15-20. https://doi.org/10.1148/radiology.150.1.6316417
  8. Gaeta M, Caruso R, Blandino A, Bartiromo G, Scribano E, Pandolfo I. Radiolucencies and cavitation in bronchioloalveolar carcinoma: CT-pathologic correlation. Eur Radiol 1999;9:55-9. https://doi.org/10.1007/s003300050627
  9. Strollo DC, Rosado-de-Christenson ML, Franks TJ. Reclassification of cystic bronchioloalveolar carcinomas to adenocarcinomas based on the revised World Health Organization Classification of Lung and Pleural Tumours. J Thorac Imaging 2003;18:59-66. https://doi.org/10.1097/00005382-200304000-00001
  10. Travis WD, Colby TV, Corrin B, Shimosato Y, Brambilla E, Sobin LH. Histological typing of lung and pleural tumours. 3rd ed. Berlin: Springer; 1999.
  11. Kuhlman JE, Kavuru M, Fishman EK, Siegelman SS. Pneumocystis carinii pneumonia: spectrum of parenchymal CT findings. Radiology 1990;175:711-4. https://doi.org/10.1148/radiology.175.3.2343118
  12. Crans CA Jr, Boiselle PM. Imaging features of Pneumocystis carinii pneumonia. Crit Rev Diagn Imaging 1999; 40:251-84. https://doi.org/10.3109/10408379991249194
  13. Boisset GF. Subpleural emphysema complicating staphylococcal and other pneumonias. J Pediatr 1972;81: 259-66. https://doi.org/10.1016/S0022-3476(72)80292-0
  14. Takemura T, Akiyama O, Yanagawa T, Ikushima S, Ando T, Oritsu M. Pulmonary tuberculosis with unusual cystic change in an immunocompromised host. Pathol Int 2000;50:672-7. https://doi.org/10.1046/j.1440-1827.2000.01086.x
  15. Lantuejoul S, Colby TV, Ferretti GR, Brichon PY, Brambilla C, Brambilla E. Adenocarcinoma of the lung mimicking inflammatory lung disease with honeycombing. Eur Respir J 2004;24:502-5. https://doi.org/10.1183/09031936.04.00124703