Asian Pacific Journal of Cancer Prevention

Asian Pacific Journal of Cancer Prevention (아시아태평양암예방학회)
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Prevalence and Genotype Distribution of Human Papillomavirus Infections in Women Attending Hospitals in Chaozhou of Guangdong Province

  • Chen, Qiang (Department of Radiobiology, School of Public Health, Jilin University) ;
  • Luo, Zhao-Yun (Laboratory Medical Center, Chaozhou Central Hospital) ;
  • Lin, Min (Laboratory Medical Center, Chaozhou Central Hospital) ;
  • Lin, Qi-Li (Department of Gynecology and Obstetrics, Chaozhou People's Hospital) ;
  • Chen, Chan-Yu (Department of Gynecology, Chaozhou Central Hospital) ;
  • Yang, Chun (Department of Gynecology, Chaozhou Central Hospital) ;
  • Xie, Long-Xu (Hybribio Limited Corporation) ;
  • Li, Hui (Department of Gynecology and Obstetrics, Chaozhou Gynecological and Pediatric Hospital) ;
  • Zheng, Jia-Kun (Laboratory Medical Center, Chaozhou Central Hospital) ;
  • Yang, Li-Ye (Laboratory Medical Center, Chaozhou Central Hospital) ;
  • Ju, Gui-Zhi (Department of Radiobiology, School of Public Health, Jilin University)
  • Published : 2012.04.30
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Abstract

Background: Human papillomavirus (HPV) infection is the main cause of cervical cancer. Limited epidemiologic data of HPV prevalence are available for women attending hospitals in southern China. This study aimed to evaluate the profiles of HPV infection and cytology status in gynecological outpatients in Chaozhou City. Methods: A total of 2833 eligible women were enrolled. The HPV GenoArray test was used for HPV detection and genotyping. Nearly one half of the HPV positive women received liquid-based cytology test. Logistic regression analysis was performed to assess the predictable effects of age and genotype for categories of abnormal cytology. Results: The prevalence of overall, high-risk, and low-risk HPV infection were 24.5%, 19.5% and 8.4%, respectively. A U-shaped age-specific prevalence curve was observed in overall HPV and high-risk HPV, but not in low-risk HPV, which declined with age increasing. The 6 most common high-risk HPV type in descending order, were types 52, 16, 58, 18, 68, and 33. Age and HPV genotype were both important determinants of abnormal cytology incidence, the older women (>45 years) and those infected with HPV type 16 and/or 18 having the highest risk for abnormal cytology. Conclusion: Our findings support the hypothesis that second-generation HPV prophylactic vaccines including HPV-52 and -58 may offer higher protection for women residing in Chaozhou and neighboring cities in Guangdong.

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References

  1. Bao YP, Li N, Smith JS, et al (2008). Human papillomavirus type distribution in women from Asia: a meta-analysis. Int J Gynecol Cancer, 18, 71-9.
  2. Bosch FX, Lorincz A, Muñoz N, et al (2002). The causal relation between human papillomavirus and cervical cancer. J Clin Pathol, 55, 244-65. https://doi.org/10.1136/jcp.55.4.244
  3. Bruni L, Diaz M, Castellsagué X, et al (2010). Cervical human papillomavirus prevalence in 5 continents: meta-analysis of 1 million women with normal cytological findings. J Infect Dis, 202, 1789-99. https://doi.org/10.1086/657321
  4. Bouvard V, Baan R, Straif K, et al (2009). A review of human carcinogens--Part B: biological agents. Lancet Oncol, 10, 321-2. https://doi.org/10.1016/S1470-2045(09)70096-8
  5. Chen HC, Schiffman M, Lin CY, et al (2011). Persistence of type-specific human papillomavirus infection and increased long-term risk of cervical cancer. J Natl Cancer Inst, 103, 1387-96. https://doi.org/10.1093/jnci/djr283
  6. Chen Q, Xie LX, Qing ZR, et al (2012). Epidemiologic characterization of human papillomavirus infection in rural chaozhou, eastern guangdong province of china. PLoS One, 7, e32149. https://doi.org/10.1371/journal.pone.0032149
  7. Clifford GM, Gallus S, Herrero R, et al (2005). Worldwide distribution of human papillomavirus types in cytologically normal women in the International Agency for Research on Cancer HPV prevalence surveys: a pooled analysis. Lancet, 366, 991-8. https://doi.org/10.1016/S0140-6736(05)67069-9
  8. de Sanjosé S, Diaz M, Castellsagué X, et al (2007). Worldwide prevalence and genotype distribution of cervical human papillomavirus DNA in women with normal cytology: a meta-analysis. Lancet Infect Dis, 7, 453-9. https://doi.org/10.1016/S1473-3099(07)70158-5
  9. Dunne EF, Unger ER, Sternberg M, et al (2007). Prevalence of HPV infection among females in the United States. JAMA, 297, 813-9. https://doi.org/10.1001/jama.297.8.813
  10. Inoue M, Sakaguchi J, Sasagawa T, et al (2006). The evaluation of human papillomavirus DNA testing in primary screening for cervical lesions in a large Japanese population. Int J Gynecol Cancer, 16, 1007-13. https://doi.org/10.1111/j.1525-1438.2006.00460.x
  11. Harper DM, Franco EL, Wheeler C, et al (2004). Efficacy of a bivalent L1 virus-like particle vaccine in prevention of infection with human papillomavirus types 16 and 18 in young women: a randomised controlled trial. Lancet, 364, 1757-65. https://doi.org/10.1016/S0140-6736(04)17398-4
  12. Herrero R (2009). Human papillomavirus (HPV) vaccines: limited cross-protection against additional HPV types. J Infect Dis, 199, 919-22. https://doi.org/10.1086/597308
  13. Hildesheim A, Wang SS (2002). Host and viral genetics and risk of cervical cancer: a review. Virus Res, 89, 229-40. https://doi.org/10.1016/S0168-1702(02)00191-0
  14. Lin H, Ma YY, Moh JS, et al (2006). High prevalence of genital human papillomavirus type 52 and 58 infection in women attending gynecologic practitioners in South Taiwan. Gynecol Oncol, 101, 40-5. https://doi.org/10.1016/j.ygyno.2005.09.028
  15. Lin M, Yang LY, Li LJ, et al (2008). Genital human papillomavirus screening by gene chip in Chinese women of Guangdong province. Aust N Z J Obstet Gynaecol, 48, 189-94. https://doi.org/10.1111/j.1479-828X.2008.00844.x
  16. Liu SS, Chan KY, Leung RC, et al (2011). Prevalence and risk factors of Human Papillomavirus (HPV) infection in southern Chinese women - a population-based study. PLoS One, 6, e19244. https://doi.org/10.1371/journal.pone.0019244
  17. Klintschar M, Neuhuber F (2000). Evaluation of an alkaline lysis method for the extraction of DNA from whole blood and forensic stains for STR analysis. J Forensic Sci, 45, 669-73.
  18. Middleton K, Peh W, Southern S, et al (2003). Organization of human papillomavirus productive cycle during neoplastic progression provides a basis for selection of diagnostic markers. J Virol, 77, 10186-201. https://doi.org/10.1128/JVI.77.19.10186-10201.2003
  19. Munoz N, Bosch FX, de Sanjose S, et al (2003). Epidemiologic classification of human papillomavirus types associated with cervical cancer. N Engl J Med, 348, 518-27. https://doi.org/10.1056/NEJMoa021641
  20. Solomon D, Davey D, Kurman R, et al (2002). The 2001 Bethesda System: terminology for reporting results of cervical cytology. JAMA, 287, 2114-9. https://doi.org/10.1001/jama.287.16.2114
  21. Sun ZR, Ji YH, Zhou WQ, et al (2010). Characteristics of HPV prevalence among women in Liaoning province, China. Int J Gynaecol Obstet, 109, 105-9. https://doi.org/10.1016/j.ijgo.2009.11.026
  22. Trottier H, Burchell AN (2009). Epidemiology of mucosal human papillomavirus infection and associated diseases. Public Health Genomics, 12, 291-307. https://doi.org/10.1159/000214920
  23. Villa LL, Costa RL, Petta CA, et al (2005). Prophylactic quadrivalent human papillomavirus (types 6, 11, 16, and 18) L1 virus-like particle vaccine in young women: a randomised double-blind placebo-controlled multicentre phase II efficacy trial. Lancet Oncol, 6, 271-8. https://doi.org/10.1016/S1470-2045(05)70101-7
  24. Wu D, Cai L, Huang M, et al (2010). Prevalence of genital human papillomavirus infection and genotypes among women from Fujian province, PR China. Eur J Obstet Gynecol Reprod Biol, 151, 86-90. https://doi.org/10.1016/j.ejogrb.2010.02.040
  25. Xue Y, Zhang W, Chen M, et al (2009). "U" shape of age-specific prevalence of high-risk human papillomavirus infection in women attending hospitals in Shanghai, China. Eur J Obstet Gynecol Reprod Biol, 145, 214-8. https://doi.org/10.1016/j.ejogrb.2009.05.020
  26. Yang L, Parkin DM, Li L, et al (2003). Time trends in cancer mortality in China: 1987-1999. Int J Cancer, 106, 771-83. https://doi.org/10.1002/ijc.11300
  27. Ye J, Cheng X, Chen X, et al (2010). Prevalence and risk profile of cervical Human papillomavirus infection in Zhejiang Province, southeast China: a population-based study. Virol J, 7, 66. https://doi.org/10.1186/1743-422X-7-66
  28. Yip YC, Ngai KL, Vong HT, et al (2010). Prevalence and genotype distribution of cervical human papillomavirus infection in Macao. J Med Virol, 82, 1724-9. https://doi.org/10.1002/jmv.21826
  29. Yoshikawa H (2009). Progress and challenges on HPV vaccination. Uirusu, 59, 243-8. https://doi.org/10.2222/jsv.59.243

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