Animal cells and systems

  • 제16권3호
  • /
  • Pages.215-223
  • /
  • 2012
  • /
  • 1976-8354(pISSN)
  • /
  • 2151-2485(eISSN)
한국통합생물학회 (The Korean Society for Integrative Biology)
권호 표지
DOI QR코드

DOI QR Code

Maturation and migration of dendritic cells upon stimulation with heat-killed tumor cells

  • Kim, Hyo-Jeong (Department of Bioscience and Biotechnology, Sejong University) ;
  • Yoon, Taek-Joon (Department of Food & Nutrition, Yuhan College) ;
  • Lee, Sung-Won (Department of Bioscience and Biotechnology, Sejong University) ;
  • Yun, Dae-Sun (Department of Bioscience and Biotechnology, Sejong University) ;
  • Kim, Ji-Yeon (School of Life Science & Biotechnology, Korea University) ;
  • Shin, Kwang-Soon (Department of Food & Biotechnology, Kyonggi University) ;
  • Park, Se-Ho (School of Life Science & Biotechnology, Korea University) ;
  • Hong, Seok-Mann (Department of Bioscience and Biotechnology, Sejong University)
  • 투고 : 2011.09.03
  • 심사 : 2011.10.04
  • 발행 : 2012.06.30
PDF 다운로드
⟨ 이전 논문 다음 논문 ⟩

초록

Recently it has been reported that immunization with heat-killed tumor cells (HK vaccine) induces anti-tumor immune responses in mice. To investigate how HKvaccine elicits anti-tumor specific adaptive immunity, we examined the effect of HK vaccination on innate immune cells such as dendritic cells (DCs), which are essential for the generation of adaptive immunity. Upon stimulation with HK vaccine, DCs matured to promote not only the upregulation of co-stimulatory molecules but also secretion of cytokine IL12. Furthermore, HK vaccine-treated DCs migrated more efficiently to draining lymph nodes compared with untreated ones. Taken together, HK vaccine can be useful as an adjuvant to activate DCs for anti-tumor immune responses.

키워드

참고문헌

  1. Banchereau J, Steinman RM. 1998. Dendritic cells and the control of immunity. Nature. 392:245-252. https://doi.org/10.1038/32588
  2. Brasel K, De Smedt T, Smith JL, Maliszewski CR. 2000. Generation of murine dendritic cells from flt3-ligandsupplemented bone marrow cultures. Blood. 96: 3029-3039.
  3. Bullock TN, Yagita H. 2005. Induction of CD70 on dendritic cells through CD40 or TLR stimulation contributes to the development of CD8-T cell responses in the absence of CD4- T cells. J Immunol. 174:710. https://doi.org/10.4049/jimmunol.174.2.710
  4. Colonna M, Pulendran B, Iwasaki A. 2006. Dednritic cells at the host-pathogen interface. Nat Immunol. 7:117-120. https://doi.org/10.1038/ni0206-117
  5. Gilliet M, Boonstra A, Paturel C, Antonenko S, Xu XL, Trinchieri G, O'Garra A, Liu YJ. 2002. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J Exp Med. 195:953-958. https://doi.org/10.1084/jem.20020045
  6. Hoebe K, Janssen E, Beutler B. 2004. The interface between innate and adaptive immunity. Nat Immunol. 5:971-974.
  7. Hurwitz AA, Kwon ED, van Elsas A. 2000. Costimulatory wars: the tumor menace. Curr Opin Immunol. 12: 589-596. https://doi.org/10.1016/S0952-7915(00)00147-3
  8. ImW, Kim H, Yun D, Seo SY, Park SH, Locksley RM, Hong S. 2005. Cytokine reporter mouse system for screening novel IL12/23 p40-inducing compounds. Mol Cells. 20:288-296.
  9. Iwasaki A, Medzhitov R. 2004. Toll-like receptor control of the adaptive immune responses. Nat Immunol. 5: 987-995. https://doi.org/10.1038/ni1112
  10. Jin MS, Lee J-O. 2009. Ligand recognition by the Toll-like receptor family. Anim Cells Syst. 13:1-8. https://doi.org/10.1080/19768354.2009.9647188
  11. Kushwah R, Hu J. 2011. Complexity of dendritic cell subsets and their function in the host immune system. Immunology. 133:409-419. https://doi.org/10.1111/j.1365-2567.2011.03457.x
  12. Langrish CL, McKenzie BS, Wilson NJ, de Waal Malefyt R, Kastelein RA, Cua DJ. 2004. IL-12 and IL-23:master regulators of innate and adaptive immunity. Immunol Rev. 202:96-105. https://doi.org/10.1111/j.0105-2896.2004.00214.x
  13. Liu Y-J. 2001. Dendritic cell subsets and lineages, and their functions in innate and adaptive immunity. Cell. 106: 259-262. https://doi.org/10.1016/S0092-8674(01)00456-1
  14. Mackey MF, Gunn JR, Maliszewsky C, Kikutani H, Noelle RJ, Barth RJ Jr. 1998. Dendritic cells require maturation via CD40 to generate protective antitumor immunity. J Immunol. 161:2094-2098.
  15. McDonnell AM, Robinson BW, Currie AJ. 2010. Tumor antigen cross-presentation and the dendritic cell: where it all begins? Clin Dev Immunol. 2010:539519.
  16. Melcher A, Todryk S, Hardwick N, Ford M, Jacobson M, Vile RG. 1998. Tumor immunogenicity is determined by the mechanism of cell death via induction of heat shock protein expression. Nat Med. 4:581-587. https://doi.org/10.1038/nm0598-581
  17. Reinhardt RL, Hong S, Kang S-J, Wang Z-e, Locksley RM. 2006. Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol. 177:1618-1627. https://doi.org/10.4049/jimmunol.177.3.1618
  18. Ribas A, Butterfield LH, Glaspy JA, Economou JS. 2003. Current developments in cancer vaccines and cellular immunotherapy. J Clin Oncol. 21:2415-2432. https://doi.org/10.1200/JCO.2003.06.041
  19. Ridge JP, Di Rosa F, Matzinger P. 1998. A conditioned dendritic cell can be a temporal bridge between a CD4- T-helper and a T-killer cell. Nature. 393:474-478. https://doi.org/10.1038/30989
  20. Riol-Blanco L, Sancnez-Sanchez N. 2005. The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed. J Immunol. 174:4070-4080. https://doi.org/10.4049/jimmunol.174.7.4070
  21. Schuster M, Nechansky A, Kircheis R. 2006. Cancer immunotherapy. Biotechnol J. 1:138-147. https://doi.org/10.1002/biot.200500044
  22. Shi H, Cao T, Connolly JE, Monnet L, Bennett L, Chapel S, Bagnis C, Mannoni P, Davoust J, Palucka AK, et al. 2006. Hyperthermia enhances CTL cross-priming. J Immunol. 176:2134-2141. https://doi.org/10.4049/jimmunol.176.4.2134
  23. Shortman K, Lahoud MH, Caminschi I. 2009. Improving vaccines by targeting antigens to dendritic cells. Exp Mol Med. 41:61-66. https://doi.org/10.3858/emm.2009.41.2.008
  24. Shortman K, Liu YJ. 2002. Mouse and human dendritic cell subtypes. Nat Rev Immunol. 2:151-161. https://doi.org/10.1038/nri746
  25. Strome SE, Voss S,Wilcox R,Wakefield TL, Tamada K, Flies D, Chapoval A, Lu J, Kasperbauer JL, Padley D, et al. 2002. Strategies for antigen loading of dendritic cells to enhance the antitumor immune response. Cancer Res. 62:1884-1889.
  26. Taraban VY, Rowley TF, Al-Shamkhani A. 2004. Cutting edge:a critical role for CD70 in CD8 T cell priming by CD40-licensed APCs. J Immunol. 173:6542-6546. https://doi.org/10.4049/jimmunol.173.11.6542
  27. Van Deusen KE, Rajapakse R, Bullock TN. 2010. CD70 expression by dendritic cells plays a critical role in the immunogenicity of CD40-independent, CD4- T celldependent, licensed CD8- T cell responses. J Leukoc Biol. 87:477-485. https://doi.org/10.1189/jlb.0809535
  28. van Duin D, Medzhitov R, Shaw AC. 2006. Triggering TLR signaling in vaccination. Trends Immunol. 27:49-55. https://doi.org/10.1016/j.it.2005.11.005
  29. Villadangos JA, Schnorrer P. 2007. Intrinsic and cooperative antigen-presenting functions of dendritic-cell subsets in vivo. Nat Rev Immunol. 7:543-555. https://doi.org/10.1038/nri2103
  30. Wan H, Dupasquier M. 2005. Dendritic cells in vivo and in vitro. Cell Mol Immunol. 2:28-35.
  31. Yoon TJ, Kim JY, Kim H, Hong C, Lee H, Lee CK, Lee KH, Hong S, Park SH. 2008. Anti-tumor immunostimulatory effect of heat-killed tumor cells. Exp Mol Med. 40: 130-144. https://doi.org/10.3858/emm.2008.40.1.130