한국자원식물학회지 (Korean Journal of Plant Resources)

  • 제25권3호
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  • Pages.339-345
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  • 2012
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  • 1226-3591(pISSN)
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  • 2287-8203(eISSN)
한국자원식물학회 (The Plant Resources Society of Korea)
권호 표지
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Suppressive Effects of Fucoxanthin on Degranulation in IgE-antigen complex-stimulated RBL-2H3 Cells

  • NamKoong, Seung (Department of Physical Therapy, Kangwon National University) ;
  • Joo, Hae-Mi (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.) ;
  • Jang, Seon-A (Radiation Health Research Institute, Korea Hydro & Nuclear Power Co., Ltd.) ;
  • Kim, Ye-Jin (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Kim, Tae-Seong (Department of Herbal Medicine Resource, Kangwon National University) ;
  • Sohn, Eun-Hwa (Department of Herbal Medicine Resource, Kangwon National University)
  • 투고 : 2012.05.30
  • 심사 : 2012.06.25
  • 발행 : 2012.06.30
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초록

The marine carotenoid fucoxanthin can be found in marine brown seaweeds, macroalgae, diatoms, and microalgae, and has remarkable biological properties. Numerous studies have shown that fucoxanthin has considerable potential and promising applications in human health, but the underlying mechanisms involved in its anti-allergic activity are not fully understood. We here investigated the mechanisms by anti-allergic activity of fucoxanthin fraction from Eisenia bicyclis in immunoglobulin E-antigen complex (IgE/DNP-BSA)-stimulated RBL-2H3 mast cells. This study we found that the fucoxanthin inhibits the release of ${\beta}$-hexosaminidase and suppressed not only transcriptional activation of NF-${\kappa}B$, but also phosphorylation of ERK and JNK in IgE/DNP-BSA-treated RBL-2H3 cells. Fucoxanthin may be useful for preventing allergic diseases, including asthma and atopic dermatitis.

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참고문헌

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