The Journal of Pediatrics of Korean Medicine (대한한방소아과학회지)

The Association of Korean Oriental Pediatrics (대한한방소아과학회)
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Effects of Nardostachys Jatamansi on Atopic Dermatitis-like Skin Lesions

甘松香 (감송향)이 아토피樣 (양) 피부염에 미치는 영향

  • Min, Deul-Le (Department of Pediatrics, College of Oriental Medicine, Wonkwang University) ;
  • Park, Eun-Jung (Department of Pediatrics, College of Oriental Medicine, Wonkwang University)
  • 민들레 (원광대학교 한의과대학 소아과학교실) ;
  • 박은정 (원광대학교 한의과대학 소아과학교실)
  • Received : 2012.04.13
  • Accepted : 2012.05.21
  • Published : 2012.05.31
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Abstract

Objectives NJ is being used to treat inflammatory diseases in Korea. In this study, we attempted to evaluate the effects of NJ on atopic dermatitis (AD)-like lesions and mast cell-mediated allergy inflammation in vivo and in vitro. Methods and Results We investigated to ascertain the pharmacological effects of NJ on 2,4-dinitrofluorobenzene (DNFB)-induced allergic reactions under in vivo conditions. Additionally, to find possible explanations for the anti-inflammatory mechanisms of NJ, we evaluated the regulatory effects of NJ on the level of inflammatory mediators in phorbol 12-myristate 13-acetate plus calcium ionophore A23187 (PMACI)-stimulated human mast cells (HMC-1). Conclusions NJ inhibited the production of the inflammatory cytokines (IgE, IL-6, IL-8 and TNF-${\alpha}$) significantly in vivo and in vitro.

Keywords

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