Journal of Pharmacopuncture (대한약침학회지)

KOREAN PHARMACOPUNCTURE INSTITUTE (대한약침학회)
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A Case Series of Survival Outcomes in Patients with Advanced-stage IIIb/IV Non-small-cell Lung Cancer Treated with HangAm-Plus

  • Bang, Sun-Hwi (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Yoon, Jeung-Won (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Cho, Chong-Kwan (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Shin, Ji-Eun (Department of Statistics, Chungnam National University) ;
  • Lee, Yeon-Weol (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Yoo, Hwa-Seung (East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
  • Received : 2011.02.28
  • Accepted : 2012.05.23
  • Published : 2012.06.30
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Abstract

Background and Objectives: Non-small-cell lung cancer (NSCLC) represents approximately 80% of all lung cancers. Unfortunately, at their time of diagnosis, most patients have advanced to unresectable disease with a very poor prognosis. The oriental herbal medicine HangAm-Plus (HAP) has been developed for antitumor purposes, and several previous studies have reported its therapeutic effects. In this study, the efficacy of HAP was evaluated as a third-line treatment for advanced-stage IIIb/IV NSCLC. Methods: The study involved six patients treated at the East- West Cancer Center (EWCC) from April 2010 to October 2011. Inoperable advanced-stage IIIb/IV NSCLC patients received 3,000 or 6,000 mg of HAP on a daily basis over a 12-week period. Computed tomography (CT) scans were obtained from the patients at the time of the initial administration and after 12 weeks of treatment. We observed and analyzed the patients overall survival (OS) and progression-free survival (PFS). Results: Of the six patients, three expired during the study, and the three remaining patients were alive as of October 31, 2011. The OS ranged from 234 to 512 days, with a median survival of 397 days and a one-year survival rate of 66.7%. In the 12-week-interval chest CT assessment, three patients showed stable disease (SD), and the other three showed progressive disease (PD). The PFS of patients ranged from 88 to 512 days, the median PFS being 96 days. Longer OS and PFS were correlated with SD. Although not directly comparable, the OS and the PFS of this study were greater than those of the docetaxel or the best supportive care group in other studies. Conclusion: HAP may prolong the OS and the PFS of inoperable stage IIIb/IV NSCLC patients without significant adverse effects. In the future, more controlled clinical trials with larger samples from multi-centers should be conducted to evaluate the efficacy and the safety of HAP.

Keywords

References

  1. World Health Organization. The global burden of disease: 2004 Update. Geneva: World Health Organization; 2008. p.12-3.
  2. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 2010;127(12):2893-917. https://doi.org/10.1002/ijc.25516
  3. Parkin DM, Bray F, Ferlay J, Pisani P. Global cancer statistics, 2002. CA Cancer J Clin. 2005;55(2):74-108. https://doi.org/10.3322/canjclin.55.2.74
  4. Ramalingam S, Belani C. Systemic chemotherapy for advanced non-small cell lung cancer: recent advances and future directions. Oncologist. 2008;13(Suppl 1):5-13. https://doi.org/10.1634/theoncologist.13-S1-5
  5. Cancer Care. Types of lung cancer. [cited 2012 January 20]. Available from: http://www.lungcancer.org/reading/types.sphp.
  6. Jemal A, Murray T, Ward E, Samuels A, Tiwari RC, Ghafoor A, et al. Cancer statistics, 2005. CA Cancer J Clin. 2005;55(1):10-30. https://doi.org/10.3322/canjclin.55.1.10
  7. Govindan R. The Washington manual of oncology. 2nd ed. Philadelphia: Lippincott Williams & Wilkins; 2007. p.134-42.
  8. Cho JH, Yoo HS, Lee YW, Son CK, Cho CK. Clinical study in 320 cases for cancer patients on the effect Hangamdan. Collect Dissert Daejeon University. 2004;12(2):157-75.
  9. Choi BL, Son CK. The clinical study in 62 cases for lung cancer patients on the effects by Hangamdan. Collect Dissert Daejeon University. 2001;10(1):121-31.
  10. Yoo HS, Choi WJ, Cho JH, Lee YY, Seo SH, Lee YW, et al. The clinical study in 105 cases for stomach cancer patients on the effects by Hangamdan. Hyehwa Med. 2000;9(2):7-25.
  11. Lee YY, Seo SH, Yoo HS, Choi WJ, Cho JH, Lee YW, et al. The clinical study in 83 cases for colorectal cancer patients on the effects by Hangamdan. J of Kor Oriental Oncology. 2000;6(1):165-80.
  12. Han SS, Cho CK, Lee YW, Yoo HS. A case report on extranodal marginal zone B cells of mucosa-associated lymphoid tissue (MALT) type lymphoma treated with HangAmDan. Korean J Orient Int Med. 2008;29(3):810-8.
  13. Bang SH, Lee JH, Cho JH, Lee YW, Son CG, Cho CK, et al. A case report of pancreatic cancer treated with lymph node metastasis. Korean J Orient Int Med. 2007;28(4):978-85.
  14. Bang JY, Kim EY, Shim TK, Yoo HS, Lee YW, Kim YS, et al. Analysis of anti-angiogenic mechanism of HangAmDan-B (HAD-B), a Korean traditional medicine, using antibody microarray chip. BioChip J. 2010;4(4):350-5. https://doi.org/10.1007/s13206-010-4412-5
  15. Choi YJ, Shin DY, Lee YW, Cho CK, Kim GY, Kim WJ, et al. Inhibition of cell motility and invasion by HangAmDan-B in NCI-H460 human non-small cell lung cancer cells. Oncol Rep. 2011;26(6):1601-8.
  16. Yoo SH, Yoo HS, Cho CK, Lee YW. A case report for recurred squamous cell lung carcinoma treated with Hang-Am-Dan: 7-year follow up. Korean J Orient Int Med. 2007;28(2):385-90.
  17. Jeong TY, Park BK, Lee YW, Cho CK, Yoo HS. Prospective analysis on survival outcomes of nonsmall cell lung cancer stages over IIIb treated with HangAm-Dan. Chinese Journal of Lung Cancer. 2010;13(11):1009-15.
  18. Eisenhauer EA, Therasse P, Bogaerts J, Schwartz LH, Sargent D, Ford R, et al. New response evaluation criteria in solid tumours: Revised RECIST guideline (version 1.1). Eur J Cancer. 2009;45(2):228-47. https://doi.org/10.1016/j.ejca.2008.10.026
  19. Oken MM, Creech RH, Tormey DC, Horton J, Davis TE, McFadden ET, et al. Toxicity and response criteria of the Eastern Cooperative Oncology Group. Am J Clin Oncol. 1982;5(6):649-55. https://doi.org/10.1097/00000421-198212000-00014
  20. Gill S, Sargent D. Endpoints for adjuvant therapy trials: has the time come to accept disease-free survival as a surrogate endpoint for overall survival? Oncologist. 2006;11(6):624-9. https://doi.org/10.1634/theoncologist.11-6-624
  21. Cancer Therapy Evaluation Program. Common Terminology Criteria for Adverse Events, Version 3.0. [cited 2012 January 20]. Available from: http://ctep.cancer.gov.
  22. Pfister DG, Johnson DH, Azzoli CG, Sause W, Smith TJ, Baker S Jr, et al. American society of clinical oncology treatment of unresectable non-small-cell lung cancer guideline: update 2003. J Clin Oncol. 2004;22(2):330-53.
  23. Driscoll JJ, Rixe O. Overall survival: still the gold standard: why overall survival remains the definitive end point in cancer clinical trials. Cancer J. 2009;15(5):401-5. https://doi.org/10.1097/PPO.0b013e3181bdc2e0
  24. Mandrekar SJ, Qi YW, Hillman SL, Allen Ziegler KL, Reuter NF, Rowland KM Jr, et al. Endpoints in phase II trials for advanced non-small cell lung cancer. J Thorac Oncol. 2010;5(1):3-9. https://doi.org/10.1097/JTO.0b013e3181c0a313
  25. Shepherd FA, Dancey J, Ramlau R, Mattson K, Gralla R, O'Rourke M, et al. Prospective randomized trial of docetaxel versus best supportive care in patients with non-small-cell lung cancer previously treated with platinum-based chemotherapy. J Clin Oncol. 2000;18(10):2095-103.
  26. Schiller JH, Harrington D, Belani CP, Langer C, Sandler A, Krook J, et al. Comparison of four chemotherapy regimens for advanced non-small-cell lung cancer. N Engl J Med. 2002;346(2):92-8. https://doi.org/10.1056/NEJMoa011954
  27. Socinski MA. The role of chemotherapy in the treatment of unresectable stage III and IV nonsmall cell lung cancer. Respir Care Clin N Am. 2003;9(2):207-36. https://doi.org/10.1016/S1078-5337(02)00089-8
  28. Noble J, Ellis PM, Mackay JA, Evans WK. Second-line or subsequent systemic therapy for recurrent or progressive non-small cell lung cancer: a systematic review and practice guideline. J Thorac Oncol. 2006;1(9):1042-58. https://doi.org/10.1097/01243894-200611000-00021
  29. Hotta K, Fujiwara Y, Kiura K, Takigawa N, Tabata M, Ueoka H, et al. Relationship between response and survival in more than 50,000 patients with advanced non-smallcell lung cancer treated with systemic chemotherapy in 143 phase III trials. J Thorac Oncol. 2007;2(5):402-7. https://doi.org/10.1097/01.JTO.0000268673.95119.c7
  30. Stinchcombe TE, Socinski MA. Considerations for second-line therapy of non-small cell lung cancer. Oncologist. 2008;13(Suppl1):28-36 https://doi.org/10.1634/theoncologist.13-S1-28