Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effect of Schisandrae Chinensis Fructus on Keratinocyte Damage by UV Irradiation

오미자(五味子)가 자외선유발 피부각질세포 손상에 미치는 효과

  • Park, Hyung-Hoon (Department of Third Medicine, Professional Graduate School of Oriental Medicine, Wonkwang University) ;
  • Lee, Jang-Suk (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Yun, Hyuk (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Hwang, Gwi-Seo (Department of Preventive Medicine, College of Oriental Medicine, Gachon University) ;
  • Chong, Myong-Soo (Department of Preventive Medicine, College of Oriental Medicine, Wonkwang University)
  • 박형훈 (원광대학교 한의학전문대학원 제3의학과) ;
  • 이장석 (원광대학교 한의과대학 예방의학교실) ;
  • 윤혁 (원광대학교 한의과대학 한방내과학교실) ;
  • 황귀서 (가천대학교 한의과대학 예방의학교실) ;
  • 정명수 (원광대학교 한의과대학 예방의학교실)
  • Received : 2012.03.20
  • Accepted : 2012.06.11
  • Published : 2012.06.25
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Abstract

This study was performed to assess the Effect of SCF(Schisandrae Chinensis Fructus) on Keratinocyte Damage by UV irradiation. The effect of SCF were determined in UV irradiated HaCaT. We measured LDH release and NO release from HaCaT to elucidate the effect of SCF. And iNOS, TNF-${\alpha}$, COX-2, Bax, Bcl-2, Bcl-xL, c-jun, c-fos gene expression were determined in HaCat using real time PCR method. The results are as follows. SCF inhibited LDH-release, NO production in UV irradiated HaCaT. SCF increased the gene expression Bax, Bcl-2 and Bcl-xL protein in UV irradiated HaCaT. SCF suppressed the gene expression TNF-${\alpha}$ in UV irradiated HaCaT. SCF suppressed the gene expression iNOS, c-fos, and c-jun in UV irradiated HaCaT. SCF not affected the suppression of the gene expression COX-2 in UV irradiated HaCaT. The study showed SCF inhibited the cell damage in UV irradiated HaCaT.

Keywords

References

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