Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Protective Effects of BJS-mix001, in Indomethacin induced Gastric Damages in Rats

BJS-Mix001이 Indomethacin 유발 랫트 위점막 손상에 미치는 영향

  • Lim, So-Yeon (Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University) ;
  • Byun, Joon-Seok (Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University) ;
  • Kim, Dae-Jun (Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University) ;
  • Kwak, Min-A (Department of Internal Medicine, College of Oriental Medicine, Daegu Hanny University)
  • 임소연 (대구한의대학교 한의과대학 내과학교실) ;
  • 변준석 (대구한의대학교 한의과대학 내과학교실) ;
  • 김대준 (대구한의대학교 한의과대학 내과학교실) ;
  • 곽민아 (대구한의대학교 한의과대학 내과학교실)
  • Received : 2012.01.20
  • Accepted : 2012.02.20
  • Published : 2012.04.25
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Abstract

The object of this study was to observe the gatro protective effects of BJS-mix001, a mixed herbal formula consisted of 4 herbal drugs Pinelliae Rhizoma : Coptidis Rhizoma : Massa Medicata Fermentata : Ostreae Testa = 1 : 1 : 1 : 1 (g/g) mixtures, which were main component of oriental medicine for treating various digestive diseases, in indomethacin induced gastric damages in rats. Three different dosages of BJS-mix001 (200, 100 and 50 mg/kg) were once orally administered 30 min before indomethacin treatment. Six hrs after indomethacin treatment, changes on the gross lesion scores, fundic histopathology, MPO activity and anti oxidant activities were observed. The results were compared with omeprazole, antioxidant and proton pump inhibitor 10 mg/kg and DA-9601, a standardized extract of the herb Artemisia asiatica 100 mg/kg treated group, respectively. As results of all three different dosages of BJS-mix001 in the indomethacin induced gastric damaged rats, significant decreased gastric damages were detected as compared with the indomethacin treated control rats. BJS-mix001 also strengthened the antioxidative defense systems - decreased the level of lipid peroxidation and catalase activity but increased the level of superoxide dismutase and glutathione contents. BJS-mix001 showed similar gastro protective effects as compared with equal dosage of DA-9601, and BJS-mix001 50 mg/kg showed slighter effects as compared with omeprazole 10 mg/kg, in the present study. The results obtained in this study suggest that BJS-mix001 showed favorable effects in the indomethacin induced gastric damages mediated by strengthening of the antioxidative defense systems.

Keywords

References

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