Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
권호 표지

Effects of Hwanggeum-tang Water Extract on the Expression of Pro-inflammatory Responses Elicited by Advanced Glycation End Products in THP-1 Cells

황금탕(黃芩湯) 추출물이 THP-1 세포에서 당화종말산물에 의한 염증반응에 미치는 효과

  • Jeong, Sang-Hun (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee, Kwang-Gyu (Department of Pathology, College of Oriental Medicine, Woosuk University) ;
  • Lee, Chang-Hyun (Department of Anatomy, College of Oriental Medicine, Woosuk University) ;
  • Lee, Sang-Ryong (Department of Meridian & Acupoint, College of Oriental Medicine, Woosuk University) ;
  • Kim, Jae-Eun (Department of Pathology, College of Oriental Medicine, Dongguk University) ;
  • Ha, Ki-Tae (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Shin, Sang-Woo (Division of Applied Medicine, School of Korean Medicine, Pusan National University) ;
  • Jeong, Han-Sol (Division of Applied Medicine, School of Korean Medicine, Pusan National University)
  • 정상훈 (우석대학교 한의과대학 병리학교실) ;
  • 이광규 (우석대학교 한의과대학 병리학교실) ;
  • 이창현 (우석대학교 한의과대학 해부학교실) ;
  • 이상룡 (우석대학교 한의과대학 경혈학교실) ;
  • 김재은 (동국대학교 한의과대학 병리학교실) ;
  • 하기태 (부산대학교 한의학전문대학원 응용의학부) ;
  • 신상우 (부산대학교 한의학전문대학원 응용의학부) ;
  • 정한솔 (부산대학교 한의학전문대학원 응용의학부)
  • Received : 2012.03.07
  • Accepted : 2012.04.12
  • Published : 2012.04.25
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Abstract

Hwanggeum-tang (HGT) was recorded in Dongeuibogam as being able to treat Sogal whose concept had been applied to Diabetes Mellitus (DM). Advanced glycation end products (AGEs) play important roles in the development of diabetic complications such as atherosclerosis by eliciting inflammatory responses. In this study, we examined the suppressive effects of HGT against inflammation elicited by AGEs. AGEs treatment increased the expression of pro-inflammatory cytokine gene TNF-${\alpha}$; chemokines MCP-1, IP-10; pro-inflammatory cyclooxygenase COX-2 on the THP-1 cells. HGT had suppressed the expression of pro-inflammatory genes and protein levels in AGE-treated THP-1 cells. HGT had also decreased intracellular ROS production stimulated by AGEs. These results suggest that HGT has beneficial effects for the improvement diabetic vascular complication through suppressing inflammatory responses elicited by AGEs.

Keywords

References

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