생약학회지 (Korean Journal of Pharmacognosy)

  • 제43권2호
  • /
  • Pages.147-151
  • /
  • 2012
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  • 0253-3073(pISSN)
  • /
  • 2288-9299(eISSN)
한국생약학회 (The Korean Society of Pharmacognosy)
권호 표지

천초근의 발암성 연구를 위한 분석 및 안정성 시험

Stability Test and Analysis of Rubia cordifolia for Carcinogenicity Study

  • 김대현 ((주)엘컴사이언스 생명과학연구소) ;
  • 박진호 ((주)엘컴사이언스 생명과학연구소) ;
  • 김승현 (연세대학교 약학대학) ;
  • 성상현 (서울대학교 약학대학)
  • Kim, Dae-Hyun (Institute for Life Science, Elcom Science Co. Ltd.) ;
  • Park, Jin-Ho (Institute for Life Science, Elcom Science Co. Ltd.) ;
  • Kim, Seung-Hyun (College of Pharmacy, Yonsei University) ;
  • Sung, Sang-Hyun (College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University)
  • 투고 : 2012.02.17
  • 심사 : 2012.04.18
  • 발행 : 2012.06.30
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초록

The marker constituent was isolated from Rubia cordifolia as a major compound. Quantitative method for the marker of the natural medicine was developed using HPLC-DAD and using established method the extract of Rubia cordifolia was evaluated. In addition, long term and accelerated stability test in the extract was examined for six months. No significant change in content of the marker constituent of the extract observed during the period of long term test.

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참고문헌

  1. 조헌영, 박위근, 김동일 등 (2007) 동의보감, 2979, 도시명 기재요망.
  2. Ino, N., Tanaka, T., Okumura, A., Morishita, Y., Makita, H., Kato, Y., Nakamura, M. and Mori, H. (1995) Acute and subacute toxicity tests of madder root, natural colorant extracted from madder (Rubia tinctorum), in (C57BL/6 X C3H)F1 mice. Toxicol. Ind. Health. 11: 449-458. https://doi.org/10.1177/074823379501100407
  3. C. Rubia tinctorum, morinda officinalis and anthraquinones. IARC Monographs. 82: 129-147.
  4. Son, J. K., Jung, J. H., Lee, C. S., Moon, D. C., Choi, S. W., Min, B. S. and Woo, M. H. (2006) DNA topoisomerases I and II inhibition and cytotoxicity of constituents from the roots of Rubia cordifolia. Bull. Korean Chem. Soc. 27: 1231- 1234. https://doi.org/10.5012/bkcs.2006.27.8.1231
  5. 식약청고시 2003-17, 안전성유효성심사규정.
  6. Banyai, P., Kuzovkina, I. N., Kursinszki, L. and Szoke, E. (2006) HPLC analysis of alizarin and purpurin produced by Rubia tinctorum L. hairy root cultures. Chromatographia Supplement. 63: S111-S114. https://doi.org/10.1365/s10337-006-0792-z
  7. Boldizsar, I., Sz cs, Z., F zfai, Z. and Molnar-Perl, I. (2006) Identification and quantification of the constituents of madder root by gas chromatography and high-performance liquid chromatography. J. Chromatogr. A. 1133: 259-274. https://doi.org/10.1016/j.chroma.2006.08.021
  8. Derksen, G. C., Lelyveld, G. P., Beek, T. A., Capelle, A. and Groot, A. (2004) Two validated HPLC methods for the quantification of alizarin and other anthraquinones in Rubia tinctorum cultivars. Phytochem. Anal. 15: 397-406. https://doi.org/10.1002/pca.800
  9. Orban, N., Boldizsar, I., Szucs, Z. and Danos, B. (2008) Influence of different elicitors on the synthesis of anthraquinone derivatives in Rubia tinctorum L. cell suspension cultures, Dyes Pigm. 77: 249-257. https://doi.org/10.1016/j.dyepig.2007.03.015
  10. Bosakova, Z. and Per l, J. (2000) Determination of lucidin in rubia tinctorum aglycones by an HPLC method with isocratic elution. J. High Resol. Chromatogr. 23: 600-602. https://doi.org/10.1002/1521-4168(20001001)23:10<600::AID-JHRC600>3.0.CO;2-7
  11. Deshkar, N., Tilloo, S. and Pande, V. A comprehensive review of Rubia cordifolia Linn. Phcog Rev. 2: 124-134.
  12. Itokawa H., Qiao, Y. and Takeya, K. (1989) Anthraquinones and naphthohtdroquinones from Rubia conrdifolia. Phytochemistry 28: 3465-3468. https://doi.org/10.1016/0031-9422(89)80365-6
  13. Singh, R., jali, G. and Chauhan, S. (2004) 9,10-Anthraquinones and other biologically active compounds from the genus Rubia. Chem. Biodivers. 1: 1241-1264. https://doi.org/10.1002/cbdv.200490088