The Korean Journal of Food And Nutrition (한국식품영양학회지)

The Korean Society of Food and Nutrition (한국식품영양학회)
권호 표지
DOI QR코드

DOI QR Code

Antioxidant and Anti-hyperglycemic Effects of a Sanghwang Mushroom(Phellinus linteusau) Water Extract

상황버섯 열수추출물의 항산화 활성과 식후 혈당 상승 억제 효과

  • 최황용 (한남대학교 식품영양학과) ;
  • 하경수 (한남대학교 식품영양학과) ;
  • 조성훈 (한남대학교 식품영양학과) ;
  • 가은혜 (한남대학교 식품영양학과) ;
  • 장흥배 (한국폴리텍바이오대학 바이오품질관리과) ;
  • 권영인 (한남대학교 식품영양학과)
  • Received : 2012.04.05
  • Accepted : 2012.05.01
  • Published : 2012.06.30
Download PDF
⟨ Previous Next ⟩

Abstract

The inhibitory activities of a water extract of Sanghwang mushroom(Phellinus linteusau)(SWE) against ${\alpha}$-glucosidases were evaluated in this study. Inhibiting these enzymes involved in the absorption of disaccharides significantly decreases the postprandial increase in blood glucose level after a mixed carbohydrate diet. Oxygen radical absorbance capacity and 1,1-diphenyl-2-picryl hydrazyl scavenging activities of the SWE were evaluated to investigate the antioxidant activity of the SWE associated with complications of long-term diabetes. Furthermore, the postprandial blood glucose lowering effect of SWE was compared to a known type 2 diabetes drug($Acarbose^{(R)}$) in a Sprague-Dawley rat model. SWE significantly reduced the blood glucose increase after sucrose loading. These results suggest that SWE, which has high ${\alpha}$-glucosidase inhibitory activity and high antioxidant activities, has the potential to contribute to a useful dietary strategy for controlling postprandial hyperglycemia.

Keywords

References

  1. Brownlee M. 2005. The pathobiology of diabetic complications. Diabetes 54:1615-1625 https://doi.org/10.2337/diabetes.54.6.1615
  2. Cheng A, Fantus I. 2005. Oral antihyperglycemic the rapy for type 2 diabetes mellitus. Can Med Assoc J 172:213-226 https://doi.org/10.1503/cmaj.1031414
  3. Cho HE, Choi YJ, Cho EK. 2010. Antioxidant and nitrite scavening activity and ${\alpha}$-glucosidase inhibitory effect of water extract from Schizandra chinensis Baillon. J Korean Soc Food Sci Nutr 39:481-486 https://doi.org/10.3746/jkfn.2010.39.4.481
  4. Choi JH, Ha TH, Rho YD. 1996. Studies on the main factors affecting the mycelial growth of Phellinus linteus. Korean J Mycol 24:214-222
  5. Hong JS, Kim, YH, Lee KR, Kim MK, Cho CI, Park KH, Choi YH, Lee JB. 1988. Composition of organic acid and fatty acid in Pleurotus ostreatus, Lentinus edodes and Agaricus bisporus. Korean J Food Sci Technol 20:100-106
  6. Jung ME, Ham SS, Nam SM, Kang IJ, Kim SJ, Chung CK. 2001. Biochemical and histological effects of Phellinus linteus methanol extract on liver lipid metabolism of rats fed $CCl_4$ and high fat. J Korean Soc Food Sci Nutr 30:331-337
  7. Kim HM, Han SB, Oh GT, Kim YH, Hong DH, Hong ND, Yoo ID. 1996. Stimulation of humoral and cell mediated immunity by polysaccharides from mushroom Phellinus linteus. Int J Immunopharmacol 18:295-303 https://doi.org/10.1016/0192-0561(96)00028-8
  8. Kim UJ, Min HK. 2005. Diabetes mellitus. Korea Diabetes Association. Korea Medical Books. Seoul, Korea. pp.165-197
  9. Kwon SH, Kim CN, Kim CY, Kwon ST, Park KM, Hwangbo S. 2003. Antitumor activities of protein-bound polysaccharide extracted from mycelia of mushroom. Korean J Food & Nutr 16:15-21
  10. Lim SS, Lee JH. 1997. Effect of Artemisia princeps var. orientalis and Circium japonica var. ussuriense on serum lipid of hyperlipidemic rat. Korean J Nutr 30:12-21
  11. Liangli Y, Scott A, Jonathan P, Mary H, John W, Ming Q. 2002. Antioxidant properties of hard winter wheat extracts. J Agric Food Chem 60: 1619-1624
  12. Marles R, Farnsworth N. 1995. Antidiabetic plants and their active constituents. Phytomedicine 2:137-165 https://doi.org/10.1016/S0944-7113(11)80059-0
  13. Oh GT, Han SB, Kim HM, Han MW, Yoo ID. 1992. Immunostimulating activity of Phellinus linteus extracts to B-lymphocyte. Arch Pharm Res 15:379-381 https://doi.org/10.1007/BF02974118
  14. Prior RL, Wu X, Schaich K 2005. Atandardized methods for the determination of antioxidant and phenolic in food and dietary supplements. J Agric Food Chem 53:4290-4302 https://doi.org/10.1021/jf0502698
  15. Pyo MY, Hyun SM, Yang KS. 2001. Effect of Phellinus lineus extracts on the humoral immune response in normal and cyclophosphamide-treated mice. J Appl Pharmacol 9:194-200
  16. Rhee YK, Han MH, Park SY, Kim DH. 2000. In vitro and in vivo antitumor activity of the fruit body of Phellinus linteus. Korean J Food Sci Technol 32:477-480
  17. Shinde J, Taldone T, Barletta M, Kunaparaju N, Hu B, Kumar S, Placido J, William ZS. 2008. ${\alpha}$-Glucosidase inhibitory activity of Syaygium cumini(Linn). Skeels seed kernel in vitro and in Goto-Kakizaki(GK) rats. Carbohydrate Res 343: 1278-1281 https://doi.org/10.1016/j.carres.2008.03.003
  18. Shon TH, Nam KS. 2001. Antimutagenicity and induction of anticarcinogenic phase II enzyme by Basidiomycetes. J Ethnopharmacol 77:103-109 https://doi.org/10.1016/S0378-8741(01)00276-8
  19. Tamura Y, Niinobe M, Arima T, Okuda H, Fujn S. 1973. Studies on aminopeptidases in rat liver and plasma. Biochim Biophys Acta 327:437-445 https://doi.org/10.1016/0005-2744(73)90427-0
  20. Yeh Gy, Eisengerg DM, Kaptchucj Tj, Pjillips RS. 2003. Systematic review of herbs and dietary supplements for glymcemic control in diabetes. Diabetes Care 26:1277-1294 https://doi.org/10.2337/diacare.26.4.1277
  21. Yin Y, Heo SI, Jung MJ, Wang MH. 2009. Antioxidant and antidiabetic effects of various sections of Astragalus membranaceus. Korean J Pharmacogn 40:1-5
  22. Zhang W, Xu YC, Guo FJ, Meng Y, Li ML. 2008. Antidiabetic effects of cinnamaldehyde and berberine and their impacts on retinol-binding protein 4 expression in rats with type 2 diabetes mellitus. Chin Med J (Engl) 121:2124-2128

Cited by

  1. Stimulation of Phenolics, Antioxidant and α-Glucosidase Inhibitory Activities During Barley (Hordeum vulgare L.) Seed Germination vol.71, pp.2, 2016, https://doi.org/10.1007/s11130-016-0549-2
  2. Antioxidant capacities and β-glucan content of ethanol extract from Phellinus baumii vol.22, pp.5, 2015, https://doi.org/10.11002/kjfp.2015.22.5.721
  3. Quality Changes of Low Temperature Storage and Storage Period of New Cultivar Dewdrop Pine Mushroom (Lentinula edodes GNA01) and Button Mushroom (Agaricus bisporus Sing.) vol.33, pp.2, 2017, https://doi.org/10.9724/kfcs.2017.33.2.174
  4. Optimization of Extraction Conditions of Pleurotus cornucopiae by Response Surface Methodology vol.43, pp.10, 2014, https://doi.org/10.3746/jkfn.2014.43.10.1565
  5. Changes in the Quality of New Cultivar Dewdrop Pine Mushroom (Lentinula edodes GNA01) Depending on the Storage Temperature vol.32, pp.5, 2016, https://doi.org/10.9724/kfcs.2016.32.5.585
  6. Antihyperglycemic α-Glucosidase Inhibitory Activity of Ethanol Extract from Neolentinus lepideus vol.43, pp.3, 2015, https://doi.org/10.4489/KJM.2015.43.3.174
  7. 상황버섯국과 생강국으로 제조한 탁주, 약주, 증류주의 품질 특성 vol.21, pp.6, 2012, https://doi.org/10.20878/cshr.2015.21.6.009
  8. 상황버섯과 영지버섯 차류 제품의 이화학적 특성 및 항산화능 vol.24, pp.1, 2012, https://doi.org/10.11002/kjfp.2017.24.1.153
  9. 상황버섯균사체 쌀을 이용한 죽의 품질특성 vol.30, pp.3, 2017, https://doi.org/10.9799/ksfan.2017.30.3.560
  10. Characterization of β-glucan extracts and purified extracts from medicinal mushrooms and their biological activities vol.26, pp.3, 2012, https://doi.org/10.11002/kjfp.2019.26.3.315
  11. 흑타리버섯으로부터 항치매성 Acetylcholinesterase 저해물질의 생산 및 PC12 신경세포사 저해 효과 vol.47, pp.4, 2019, https://doi.org/10.4489/kjm.20190039