Toxicological Research

  • 제28권2호
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  • Pages.93-98
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  • 2012
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  • 1976-8257(pISSN)
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  • 2234-2753(eISSN)
한국독성학회 (Korean Society of Toxicology & Korea Environmental Mutagen Society)
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The Association of Heavy Metal of Blood and Serum in the Alzheimer's Diseases

  • Lee, Ji-Yeon (Advanced Analysis Center, Korea Institute of Science and Technology) ;
  • Kim, Jae-Hoon (Advanced Analysis Center, Korea Institute of Science and Technology) ;
  • Choi, Dal-Woong (Department of Environmental Health, College of Health Sciences, Korea University) ;
  • Lee, Dong-Woo (Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, INJE University) ;
  • Park, Jun-Hyun (Department of Psychiatry, Sanggye Paik Hospital, College of Medicine, INJE University) ;
  • Yoon, Hye-Jung (National Institute of Food And Drug Safety Evaluation) ;
  • Pyo, Hee-Soo (Molecular Recognition Research Center, Korea Institute of Science and Technology) ;
  • Kwon, Ho-Jang (Department of Preventive Medicine, Dankook University College of Medicine) ;
  • Park, Kyung-Su (Advanced Analysis Center, Korea Institute of Science and Technology)
  • 투고 : 2012.06.06
  • 심사 : 2012.06.15
  • 발행 : 2012.06.30
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초록

This study has attempted to establish an analysis method through validation against heavy metals in the body (Pb, Cd and Hg) using ICP-MS and Gold amalgamation and find out the relevance between heavy metal and Alzheimer's disease after analyzing the distribution of heavy metal concentration (Pb, Cd and Hg) and correlations between a control group and Alzheimer's disease group. In this study, Pb and Cd levels in the blood and serum were validation using ICP-MS. For analysis of Hg levels in the blood and serum, the gold amalgamation-based 'Direct Mercury Analyzer' has been used. According to an analysis on the heavy metal concentration (Pb, Cd and Hg concentration) in the blood, Cd concentration was high in the Alzheimer's disease group. In the serum, on the contrary, Pb and Hg were high in the Alzheimer's disease group. For analysis of correlations between heavy metal levels in the blood and serum and Alzheimer's disease, t-test has been performed. Even though correlations were observed between the blood lead levels and Alzheimer's disease, they were statistically insignificant because the concentration was higher in a control group. No significance was found in Cd and Hg. In the serum, on the other hand, no statistical significance was found between the heavy metal (Pb, Cd and Hg) and Alzheimer's disease. In this study, no statistical significance was observed between heavy metal and decrease in cognitive intelligence. However, it appears that a further study needs to be performed because the results of the conventional studies were inconsistent.

키워드

참고문헌

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피인용 문헌

  1. Heavy Metals and Neurodegenerative Diseases: An Observational Study vol.161, pp.2, 2014, https://doi.org/10.1007/s12011-014-0094-5
  2. Mercury Involvement in Neuronal Damage and in Neurodegenerative Diseases pp.1559-0720, 2018, https://doi.org/10.1007/s12011-018-1380-4