한국어병학회지 (Journal of fish pathology)

  • 제25권1호
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  • Pages.1-10
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  • 2012
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  • 1226-0819(pISSN)
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  • 2233-5412(eISSN)
한국어병학회 (The Korean Society of Fish Pathology)
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N-acetylcysteine (NAC)이 어류의 비특이적 면역 parameter인 호흡폭발 및 lysozyme활성에 미치는 영향

Effects of N-acetylcysteine (NAC) on non-specific immune parameters, respiratory burst and lysozyme activities, in different fishes

  • 안재영 (군산대학교 해양과학대학 수산생명의학과.해양생명과학과) ;
  • 이한나 (군산대학교 해양과학대학 수산생명의학과.해양생명과학과) ;
  • 박경일 (군산대학교 해양과학대학 수산생명의학과.해양생명과학과) ;
  • 김종연 (군산대학교 해양과학대학 수산생명의학과.해양생명과학과) ;
  • 이정열 (군산대학교 해양과학대학 수산생명의학과.해양생명과학과) ;
  • 박관하 (군산대학교 해양과학대학 수산생명의학과.해양생명과학과)
  • An, Jae-Young (Departments of Aquatic Life Medicine and Aquaculture & Aquatic Sciences, Kunsan National University) ;
  • Lee, Han-Na (Departments of Aquatic Life Medicine and Aquaculture & Aquatic Sciences, Kunsan National University) ;
  • Park, Kyung-Il (Departments of Aquatic Life Medicine and Aquaculture & Aquatic Sciences, Kunsan National University) ;
  • Kim, Jong-Yeon (Departments of Aquatic Life Medicine and Aquaculture & Aquatic Sciences, Kunsan National University) ;
  • Lee, Jeong-Yeol (Departments of Aquatic Life Medicine and Aquaculture & Aquatic Sciences, Kunsan National University) ;
  • Park, Kwan-Ha (Departments of Aquatic Life Medicine and Aquaculture & Aquatic Sciences, Kunsan National University)
  • 투고 : 2011.09.01
  • 심사 : 2012.02.07
  • 발행 : 2012.04.30
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초록

여러 항산화물질이 어류의 비특이적 면역능을 증강시키는 것이 알려져 있다. 본 연구에서는 glutathione의 생합성 전구체인 항산화물질 N-acetylcysteine(NAC)이 8종의 어류에서 비특이적 면역지표를 증가시키는 지를 검토하였다. NAC를 10 mg/kg의 용량으로 메기, 미꾸라지, 잉어, 붕어, 뱀장어, 가물치, 틸라피아 및 숭어에 복강내로 투여하고, 48시간 후 두신백혈구 세포의 화학발광반응 및 혈청 lysozyme 활성을 측정하였다. 붕어와 미꾸라지를 제외한 6종의 어류에서 화학발광 반응이, 틸라피아를 제외한 모든 어류에서 lysozyme 활성이 각각 증가하였다. 이 결과는 NAC가 다양한 어종에서 비특이적 면역증을 증가시키며, 이 현상은 어류양식에서의 실용화도 고려해 볼 가치가 있음을 의미한다.

It has been reported that various anti-oxidant substances stimulate non-specific immune responses in fishes. In this study it was examined whether N-acetylcysteine (NAC), an anti-oxidant glutathione (GSH) precursor, can modulate non-specific immune parameters in 8 different fishes. NAC was intraperitoneally administered at 10 mg/kg to catfish (Silurus asotus), loach (Misgurnus mizolepis), common carp (Cyprinus carpio), crucian carp (Carassius carassius), eel (Anguilla japonica), snakehead (Channa argus), tilapia (Oreochromis niloticus) and mullet (Mugil cephalus). Forty-eight hours later, chemiluminescence (CL) response of head-kidney leukocytes and serum lysozyme activity were assessed. In all fishes except crusian carp and loach, CL responses were amplified by NAC. Lysozyme activity was increased by NAC in all fish species but not in tilapia. This result suggests that NAC stimulates non-specific immune responses in various species, and that such effects may have beneficial significance in aquaculture for practical utilization.

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피인용 문헌

  1. 항산화물질 N-acetylcysteine (NAC)이 메기에서 비특이적 면역지표인 화학발광 반응에 미치는 영향 vol.32, pp.1, 2012, https://doi.org/10.7847/jfp.2019.32.1.021