한국식품영양학회지 (The Korean Journal of Food And Nutrition)

  • 제25권1호
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  • Pages.99-104
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  • 2012
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  • 1225-4339(pISSN)
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  • 2287-4992(eISSN)
한국식품영양학회 (The Korean Society of Food and Nutrition)
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C57BLKS/J-db/db 마우스에서 흑삼의 당뇨 합병증 개선 효과

Ameliorative Effect of Black Ginseng on Diabetic Complications in C57BLKS/J-db/db Mice

  • 김애정 (경기대학교 대체의학대학원 대체의학과) ;
  • 유현숙 (경기대학교 대체의학대학원 대체의학과) ;
  • 강신정 (중부대학교 한약자원학과)
  • Kim, Ae-Jung (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Yoo, Hyun-Sook (The Graduate School of Alternative Medicine, Kyonggi University) ;
  • Kang, Shin-Jung (Dept. of Medicine Resources, Graduate School of Jungboo University)
  • 투고 : 2012.01.13
  • 심사 : 2012.02.15
  • 발행 : 2012.03.31
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초록

The goal of this study was to examine the ameliorative effects of black ginseng(BG) in male obese diabetic C57BLKS/ J-db/db mice. Ten-week-old male db/db mice were administrated 300 mg/kg of F-BG daily for 6 weeks, The db/db mice where corresponded to the normal group and db/db mice which were the diabetic positive group were not provided BG treatment. The supressive effects of treatment were examined on serum lipids levels, which included total cholesterol, triglyceride, LDL-cholesterol and nonesterified fatty acid. Also, weight changes and the relative weight of liver and kidney, organ pathological investigation were measured. The effects of treatment were assessed by comparing the results of the db/db mice that received BG for 6 weeks with that of the diabetic positive group. Significant differences in several biological parameters such as HDL level(p<0.05), TG level(p<0.05) and NEFA level(p<0.05) were observed for the BG group. BG treatment increased the HDL level and decreased the NEFA level, which could ameliorate hyperlipidemia or blood circulation.

키워드

참고문헌

  1. Choi DG, Jung HJ, Chang YC, Kang SA, Ahn DK, Park SK. 2002. Effect of dansamchunghyul-tang on hyperlipidemia on rat. Korean J Oriental Medical Physiology & Pathology 16:1138-1142
  2. Garriques S. 1854. On panaquilon, a new vegetable substance. Ann Chem Pharm 90:231-234 https://doi.org/10.1002/jlac.18540900216
  3. Grundy SM, Denke MA. 1990. Dietary influence on serum lipids and lipoprotein. J Lipid Res 31:1149-1172
  4. Han ST, Whang WK, Kim IH, Yang BW, Cho SH, Ko SK. 2005. Analysis of ginsenosides of black ginseng. Yakhak Hoeji 49:490-494
  5. Jeong YH. 2010. Study on immunomodulating and anti-diabetic activity of the extract of the extract of black ginseng. Masters Degree Thesis. Konyang Uni. Nonsan. Korea
  6. Jo HH. 2009. Manufacturing black-ginseng by organic acid digestion method and anti-obesity, anti-oxidant activity of black ginseng. Masters Degree Thesis. Chungnam National Uni. Daejeon. Korea
  7. Kim AJ, Lim HJ, Kang SJ. 2010. Quality characteristics of black ginseng jelly. Korean J Food Nutr 23:196-202
  8. Kim JK, Kim YJ, Fillmore JJ, Chen Y, Moore I, Lee J, Yuan M, Li ZW, Karin M, Perret P, Shoelson SE, Shulman GI. 2001. Prevention of fat-induced insulin resistance by salicylate. J Clin Invest 108:437-446 https://doi.org/10.1172/JCI11559
  9. Kim JS. 2000. The current status of Korean Coronary Heart Disease. In Diagnosis and Treatment in Hyperlipidemia. Association of Hyperlipidemic Therapy, pp.64-74. Haneuyhak, Seoul.
  10. Kim SN, Kang SJ. 2009. Effects of black ginseng(9 times-steaming ginseng) on hypoglycemic action and changes in the composition of ginsenosides on the steaming process. Korean J Food Sci Technol 41:77-81
  11. Kimura M, Suzuki J. 1995. Pharmacological role of ginseng in the blend effect of traditional Chinese medicine in hyperglycemia. pp.181-192. World Scientific Publ Co. Singapore.
  12. Masiello P. 2006. Animal models of type 2 diabetes with reduced pancreatic ${\beta}$-cell mass. Int J Biochem Cell Biol 38:873-893 https://doi.org/10.1016/j.biocel.2005.09.007
  13. Nam KY. 2005. The competitive understanding between red ginseng and white ginsengs, processed ginsengs. J Ginseng Res 29:1-18 https://doi.org/10.5142/JGR.2005.29.1.001
  14. Parks EJ. 2002. Dietary carbohydrate's effects on lipogenesis and the relationship of lipogenesis to blood insulin and glucose concentrations. Br J Nutr 87:247-253 https://doi.org/10.1079/BJN/2002544
  15. Ryu GH. 2003. Present status of red ginseng products and its manufacturing process. Food Indust and Nutr 8:38-42
  16. Shibata S, Tanaka O, Ando T, Sado M, Tsushima S, Obsawa T. 1966. Chemical studies on oriental plants drugs: Protopanaxadiol, a genuine sapogenin of ginseng saponins. Chem Pharm Bull 14:595-600 https://doi.org/10.1248/cpb.14.595
  17. Shon MY, Choi SY, Cho HS, Sung NJ. 2004. Effects of cereal and red ginseng folur on blood glucose and lipid level in streptozotocin-induced diabetic rats. J Korean Soc Food Sci Nutr 33:1363-1468 https://doi.org/10.3746/jkfn.2004.33.9.1463
  18. Song GY, Oh HJ, Roh SS, Seo YB, Park YJ, Myung CS. 2006. Effect of black ginseng on body weight and lipid profiles in male rats fed normal diets. Yakhak Hoeji 50:381-385
  19. Steiner G, Haynes F, Yoshino G. 1984. Hypeinsulinemia and in vivo very low density lipoprotein triglyceride kinetics. Am J Physio 246:187-192
  20. Tesutani TM, Taketo Y, Kadono K, Makino J. 1994. Clinical application of red ginseng powder on cerebrovascular disease: Ling term fellow-up study. Ginseng Rev 18:91-94
  21. Wolff SP, Dean RT. 1987. Glucose autooxidation and protein modification: The potential role of autooxidation glycosylation in diabetes. Biochemial Journal 245:243-246 https://doi.org/10.1042/bj2450243
  22. Young IR, Stout RW. 1987. Effects of insulin and glucose on the cells of the arterial wall: Interaction of insulin and with dibutyl cyclic AMP and low density lipoprotein in arterial cells. Diabetes Metab 13:301-306
  23. 김화영, 조미숙, 장영애, 원례숙, 이현숙, 양은주. 2010. 임상영양학. pp.177-183. 신광출판사
  24. 통계청. 2008. 2006년 사망 및 사상 원인 통계 결과. p.20

피인용 문헌

  1. The Anti-Diabetic Effects and Nephroprotective Effect of Black Ginseng Prosapogenin Extract in Streptozotocin-Induced Mice vol.24, pp.2, 2016, https://doi.org/10.7783/KJMCS.2016.24.2.115
  2. Effects of ramie leaf extract on blood glucose and lipid metabolism in db/db mice vol.57, pp.5, 2014, https://doi.org/10.1007/s13765-014-4193-y
  3. Black Ginseng and Its Saponins: Preparation, Phytochemistry and Pharmacological Effects vol.24, pp.10, 2012, https://doi.org/10.3390/molecules24101856
  4. 고려인삼과 당뇨병: 세포와 동물 및 인체실험을 통한 고려인삼의 당뇨병에 대한 효능 vol.51, pp.1, 2012, https://doi.org/10.22889/kjp.2020.51.1.001
  5. 흑삼 및 흑마늘을 이용한 블랙잼 유동특성 모니터링 vol.37, pp.2, 2012, https://doi.org/10.12925/jkocs.2020.37.2.183