Journal of Korean Neurosurgical Society

The Korean Neurosurgical Society (대한신경외과학회)
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Extraneural Metastasis of Glioblastoma Multiforme Presenting as an Unusual Neck Mass

  • Seo, Young-Jun (Department of Neurosurgery & Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Cho, Won-Ho (Department of Neurosurgery & Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Kang, Dong-Wan (Department of Neurosurgery & Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine) ;
  • Cha, Seung-Heon (Department of Neurosurgery & Medical Research Institute, Pusan National University Hospital, Pusan National University School of Medicine)
  • Received : 2011.02.14
  • Accepted : 2012.03.08
  • Published : 2012.03.28
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Abstract

Glioblastoma multiforme(GBM) is the most aggressive intracranial tumor and it commonly spreads by direct extension and infiltration into the adjacent brain tissue and along the white matter tract. The metastatic spread of GBM outside of the central nervous system (CNS) is rare. The possible mechanisms of extraneural metastasis of the GBM have been suggested. They include the lymphatic spread, the venous invasion and the direct invasion through dura and bone. We experienced a 46-year-old man who had extraneural metastasis of the G8M on his left neck. The patient was treated with surgery for 5 times, radiotherapy and chemotherapy. He had survived 6 years since first diagnosed. Although the exact mechanism of the extraneural metastasis is not well understood, this present case shows the possibility of extraneural metastasis of the G8M, especially in patients with long survival.

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