DOI QR코드

DOI QR Code

Intramedullary Spinal Cord Metastasis of Choriocarcinoma

  • Ko, Jun-Kyeung (Department of Neurosurgery, School of Medicine, Pusan National University) ;
  • Cha, Seung-Heon (Department of Neurosurgery, School of Medicine, Pusan National University) ;
  • Lee, Jung-Hwan (Department of Neurosurgery, Armed Forces Daejeon Hospital) ;
  • Choi, Chang-Hwa (Department of Neurosurgery, School of Medicine, Pusan National University)
  • 투고 : 2011.10.19
  • 심사 : 2012.03.15
  • 발행 : 2012.03.28

초록

The authors describe a case of choriocarcinoma that metastasized to the cerebral cortex, vertebral body, and intramedullary spinal cord. A 21-year-old woman presented with sudden headache, vomiting and a visual field defect. Brain computed tomography and magnetic resonance examinations revealed an intracranial hemorrhage in the left temporo-parietal lobe and two enhancing nodules in the left temporal and right frontal lobe. After several days, the size of the hemorrhage increased, and a new hemorrhage was identified in the right frontal lobe. The hematoma and enhancing mass in the left temporo-parietal lobe were surgically removed. Choriocarcinoma was diagnosed after histological examination. At 6 days after the operation, her consciousness had worsened and she was in a state of stupor. The size of the hematoma in the right frontal lobe was enlarged. We performed an emergency operation to remove the hematoma and enhancing mass. Her mental status recovered slowly. Two months thereafter, she complained of paraplegia with sensory loss below the nipples. Whole spine magnetic resonance imaging revealed a well-enhancing mass in the thoracic intramedullary spinal cord and L2 vertebral body. Despite chemotherapy and radiotherapy, the patient died 13 months after the diagnosis.

키워드

참고문헌

  1. Athanassiou A, Begent RH, Newlands ES, Parker D, Rustin GJ, Bagshawe KD : Central nervous system metastases of choriocarcinoma. 23 years' experience at Charing Cross Hospital. Cancer 52 : 1728-1735, 1983 https://doi.org/10.1002/1097-0142(19831101)52:9<1728::AID-CNCR2820520929>3.0.CO;2-U
  2. Bagshawe KD : Treatment of high-risk choriocarcinoma. J Reprod Med 29 : 813-820, 1984
  3. BeŞkonakli E, Cayli S, Kulaçoğlu S : Metastatic choriocarcinoma in the thoracic extradural space : case report. Spinal Cord 36 : 366-367, 1998 https://doi.org/10.1038/sj.sc.3100570
  4. Chandra SA, Gilbert EF, Viseskul C, Strother CM, Haning RV, Javid MJ : Neonatal intracranial choriocarcinoma. Arch Pathol Lab Med 114 : 1079-1082, 1990
  5. Chang IB, Cho BM, Park SH, Yoon DY, Oh SM : Metastatic choriocarcinoma with multiple neoplastic intracranial microaneurysms : case report. J Neurosurg 108 : 1014-1017, 2008 https://doi.org/10.3171/JNS/2008/108/5/1014
  6. Kuten A, Cohen Y, Tatcher M, Kobrin I, Robinson E : Pregnancy and delivery after successful treatment of epidural metastatic choriocarcinoma. Gynecol Oncol 6 : 464-466, 1978 https://doi.org/10.1016/0090-8258(78)90056-2
  7. Lee JH, Park CW, Chung DH, Kim WK : A case of lumbar metastasis of choriocarcinoma masquerading as an extraosseous extension of vertebral hemangioma. J Korean Neurosurg Soc 47 : 143-147, 2010 https://doi.org/10.3340/jkns.2010.47.2.143
  8. Lewis JL Jr : Diagnosis and management of gestational trophoblastic disease. Cancer 71 : 1639-1647, 1993 https://doi.org/10.1002/cncr.2820710430
  9. Lurain JR : Management of high-risk gestational trophoblastic disease. J Reprod Med 43 : 44-52, 1998
  10. Menegaz RA, Resende AD, da Silva CS, Barcelos AC, Murta EF : Metastasis of choriocarcinoma to lumbar and sacral column. Eur J Obstet Gynecol Reprod Biol 113 : 110-113, 2004 https://doi.org/10.1016/j.ejogrb.2003.09.029
  11. Naito Y, Akeda K, Kasai Y, Matsumine A, Tabata T, Nagao K, et al. : Lumbar metastasis of choriocarcinoma. Spine (Phila Pa 1976) 34 : E538-E543, 2009 https://doi.org/10.1097/BRS.0b013e3181a98746
  12. Sierra-Bergua B, Sanchez-Marteles M, Cabrerizo-Garcia JL, Sanjoaquin-Conde I : Choriocarcinoma with pulmonary and cerebral metastases. Singapore Med J 49 : e286-e288, 2008
  13. Suresh TN, Santosh V, Shastry Kolluri VR, Jayakumar PN, Yasha TC, Mahadevan A, et al. : Intracranial haemorrhage resulting from unsuspected choriocarcinoma metastasis. Neurol India 49 : 231-236, 2001
  14. Vani R, Kuntal R, Koteshwar RK : Choriocarcinoma following term pregnancy with bone metastasis. Int J Gynaecol Obstet 40 : 252-253, 1993 https://doi.org/10.1016/0020-7292(93)90841-J

피인용 문헌

  1. Metastatic choriocarcinoma to the lumbar spine: Case report and review of literature vol.5, pp.1, 2012, https://doi.org/10.4103/2152-7806.145205
  2. A case of choriocarcinoma with concurrent rare presentations: Spontaneous uterine rupture and extensive thoracic spine metastases vol.36, pp.5, 2016, https://doi.org/10.3109/01443615.2015.1127904
  3. Spontaneous renal hemorrhage secondary to choriocarcinoma in a man with congenital hypospadias and cryptorchidism: a case report and literature review vol.18, pp.None, 2012, https://doi.org/10.1186/s12885-018-4424-4
  4. Excellent Outcome in a Patient with Choriocarcinoma with Spinal Metastasis with Cord Compression vol.17, pp.3, 2012, https://doi.org/10.1007/s40944-019-0319-9